Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway

• Published in: Journal of pineal research Vol. 68; no. 3; pp. e12638 - n/a
• Main Authors: Lee, Sung‐Eun, Koh, Hong, Joo, Dong Jin, Nedumaran, Balachandar, Jeon, Hwang‐Ju, Park, Chul‐Seung, Harris, Robert A., Kim, Yong Deuk
• Format: Journal Article
• Language: English
• Published: England 01.04.2020
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; alcoholic liver disease; Animals; Cytochrome P-450 CYP2E1 - metabolism; cytochrome P450 2E1; Humans; Liver Diseases, Alcoholic - metabolism; melatonin; Melatonin - metabolism; metabolism; Mice; oxidative liver injury; Oxidative Stress - physiology; reactive oxygen species; Signal Transduction - physiology; Sirt1; Sirtuin 1 - metabolism; Ubiquitin-Protein Ligases - metabolism; YY1 Transcription Factor - metabolism; alcoholic liver disease; cytochrome P450 2E1; reactive oxygen species; oxidative liver injury; Sirt1; metabolism; melatonin

Alcoholic liver disease is the most prevalent chronic liver disease. Melatonin is known to control many vital processes. Here, we explored a novel molecular mechanism by which melatonin‐induced SIRT1 signaling protects against alcohol‐mediated oxidative stress and liver injury. Gene expression profi...