Increased Basement Membrane Components in Adipose Tissue During Obesity: Links With TGFβ and Metabolic Phenotypes
Context:Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.Objective:Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component...
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| Published in | The journal of clinical endocrinology and metabolism Vol. 101; no. 6; pp. 2578 - 2587 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.06.2016
Copyright by The Endocrine Society Endocrine Society |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Context:Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.Objective:Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms.Design and Setting:We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells.Results:BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes.Conclusion:The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells. |
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| AbstractList | Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.CONTEXTCollagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms.OBJECTIVEOur objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms.We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells.DESIGN AND SETTINGWe used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells.BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes.RESULTSBM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes.The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells.CONCLUSIONThe disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells. Context:Collagen accumulation around adipocytes and vessels (i.e. pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.Objective:To evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms.Design and setting:We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells.Results:BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects, and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes six months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 over-expression in endothelial cells, and not in adipocytes.Conclusion:The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells.- See more at: press.endocrine.org/doi/10.1210/jc.2015-4304#sthash.oTOEmQow.dpuf Context:Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism.Objective:Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms.Design and Setting:We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells.Results:BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes.Conclusion:The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells. CONTEXT:Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism. OBJECTIVE:Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms. DESIGN AND SETTING:We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells. RESULTS:BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes. CONCLUSION:The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells.“We evaluate components of basement membrane (BM) in adipose tissue (AT) and its relationships with metabolic parameters and TGFb isoforms. Disorganization of BM components could contribute to pathological alterations of obese AT.” Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue associated with altered metabolism. Our objective was to evaluate components of basement membrane (BM) in adipose tissue, including collagen IV, a major BM component, and its relationships with metabolic parameters and TGFβ isoforms. We used immuno-techniques and gene expression approaches to detect BM components in subcutaneous and visceral adipose tissue samples. Adipocytes and endothelial cells were isolated from lean and obese adipose tissue. We also focused on the expression of COL4A1 correlated to metabolic variables in moderate obesity and, in severe obesity before and after bariatric surgery. Using in vitro analysis, we explored the impact of TGFβ isoforms on the expression of inflammatory and extracellular matrix genes in adipocytes and endothelial cells. BM components were detected around adipocytes and endothelial cells, and were increased in obese adipocytes. COL4A1 expression was positively correlated with insulin-resistance indices in obese subjects and showed less reduction in severely obese subjects with poorer insulin-resistance outcomes 6 months after gastric bypass. COL4A1 expression also correlated with TGFβ1 and TGFβ3 gene expressions in subcutaneous adipose tissue. Stimulating isolated adipocytes and endothelial cells in vitro with these TGFβ isoforms showed an inflammatory and pro-fibrotic phenotype. However, TGFβ1 and TGFβ3 exposure only provoked COL4A1 overexpression in endothelial cells and not in adipocytes. The disorganization of several BM components, including collagen IV, could contribute to pathological alterations of obese adipose tissue and cells. |
| Author | Bouillot, Jean-Luc Bichet, Jean-Christophe Prifti, Edi Lacasa, Danièle Clément, Karine Rouault, Christine Rizkalla, Salwa Tordjman, Joan Reggio, Sophie Poitou, Christine |
| AuthorAffiliation | Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France; Nutriomics Team (S.R., C.R., C.P., D.L., J.T., K.C.), INSERM, UMR_S U1166, Paris, France; Sorbonne Universités (S.R., C.R., C.P., D.L., J.T., K.C.), Université Pierre et Marie Curie, UMR_S 1166, Paris, France; Plastic Surgery and Mammary Cancer Department (J.-C.B.), Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; and Visceral Surgery Department (J.-L.B.), Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne, France |
| AuthorAffiliation_xml | – name: Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France; Nutriomics Team (S.R., C.R., C.P., D.L., J.T., K.C.), INSERM, UMR_S U1166, Paris, France; Sorbonne Universités (S.R., C.R., C.P., D.L., J.T., K.C.), Université Pierre et Marie Curie, UMR_S 1166, Paris, France; Plastic Surgery and Mammary Cancer Department (J.-C.B.), Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; and Visceral Surgery Department (J.-L.B.), Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne, France |
| Author_xml | – sequence: 1 givenname: Sophie surname: Reggio fullname: Reggio, Sophie organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 2 givenname: Christine surname: Rouault fullname: Rouault, Christine organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 3 givenname: Christine surname: Poitou fullname: Poitou, Christine organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 4 givenname: Jean-Christophe surname: Bichet fullname: Bichet, Jean-Christophe organization: 4Plastic Surgery and Mammary Cancer Department (J.-C.B.), Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France – sequence: 5 givenname: Edi surname: Prifti fullname: Prifti, Edi organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 6 givenname: Jean-Luc surname: Bouillot fullname: Bouillot, Jean-Luc organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 7 givenname: Salwa surname: Rizkalla fullname: Rizkalla, Salwa organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 8 givenname: Danièle surname: Lacasa fullname: Lacasa, Danièle organization: 2Nutriomics Team (S.R., C.R., C.P., D.L., J.T., K.C.), INSERM, UMR_S U1166, Paris, France – sequence: 9 givenname: Joan surname: Tordjman fullname: Tordjman, Joan email: joan.tordjman@upmc.fr organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France – sequence: 10 givenname: Karine surname: Clément fullname: Clément, Karine organization: 1Nutrition Department (S.R., C.R., C.P., E.P., S.R., J.T., K.C.), Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France |
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| SubjectTerms | Adipocytes Adipocytes - metabolism Adipose tissue Adipose Tissue - metabolism Basement Membrane - metabolism Basement membranes Body fat Cells, Cultured Collagen Collagen (type IV) Collagen Type IV - genetics Collagen Type IV - metabolism Endocrinology and metabolism Endothelial cells Endothelial Cells - metabolism Extracellular matrix Female Fibrosis Gastric bypass Gastrointestinal surgery Gene expression Human health and pathology Humans Inflammation Insulin Isoforms Life Sciences Male Metabolism Middle Aged Obesity Obesity - metabolism Phenotypes Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta3 - genetics Transforming Growth Factor beta3 - metabolism Transforming growth factor-b1 |
| Title | Increased Basement Membrane Components in Adipose Tissue During Obesity: Links With TGFβ and Metabolic Phenotypes |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201606000-00036 https://www.ncbi.nlm.nih.gov/pubmed/27049236 https://www.proquest.com/docview/3164368640 https://www.proquest.com/docview/1793906667 https://hal.sorbonne-universite.fr/hal-01311833 |
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