An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications...

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Bibliographic Details
Published inJournal of magnetic resonance (1997) Vol. 193; no. 2; pp. 274 - 285
Main Authors Tsai, L.L., Mair, R.W., Rosen, M.S., Patz, S., Walsworth, R.L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2008
Subjects
Equipment Design
Equipment Failure Analysis
Helium
Humans
Hyperpolarized noble gas
Image Enhancement - instrumentation
Image Interpretation, Computer-Assisted - instrumentation
Imaging, Three-Dimensional - instrumentation
Isotopes
Low magnetic field
Lung - anatomy & histology
Lung imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - instrumentation
Open access
Posture
Transducers
Low magnetic field
Magnetic resonance imaging
Hyperpolarized noble gas
Open access
Lung imaging
Online AccessGet full text
ISSN1090-7807
1096-0856
1096-0856
DOI10.1016/j.jmr.2008.05.016

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Abstract We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B 0 coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3He images with up to 2.8 mm resolution, and present initial 2D and 3D 3He images of human lungs in both supine and upright orientations. 1H MRI can also be performed for diagnostic and calibration reasons.
AbstractList We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in-vivo hyperpolarized 3 He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B 0 coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3 He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y , and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q -spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3 He images with up to 2.8 mm resolution, and present initial 2D and 3D 3 He images of human lungs in both supine and upright orientations. 1 H MRI can also be performed for diagnostic and calibration reasons.
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B 0 coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3He images with up to 2.8 mm resolution, and present initial 2D and 3D 3He images of human lungs in both supine and upright orientations. 1H MRI can also be performed for diagnostic and calibration reasons.
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B(0) coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3He images with up to 2.8mm resolution, and present initial 2D and 3D 3He images of human lungs in both supine and upright orientations. 1H MRI can also be performed for diagnostic and calibration reasons.
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B(0) coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3He images with up to 2.8mm resolution, and present initial 2D and 3D 3He images of human lungs in both supine and upright orientations. 1H MRI can also be performed for diagnostic and calibration reasons.We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B(0) coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3He images with up to 2.8mm resolution, and present initial 2D and 3D 3He images of human lungs in both supine and upright orientations. 1H MRI can also be performed for diagnostic and calibration reasons.
Author Rosen, M.S.
Mair, R.W.
Walsworth, R.L.
Tsai, L.L.
Patz, S.
AuthorAffiliation a Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138
e Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115
d Department of Physics, Harvard University, Cambridge, MA 02138
b Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139
c Harvard Medical School, Boston, MA 02115
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– name: b Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139
– name: e Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115
– name: d Department of Physics, Harvard University, Cambridge, MA 02138
– name: c Harvard Medical School, Boston, MA 02115
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/18550402$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0730-725X(03)00178-4
10.1007/s10334-004-0035-y
10.1002/mrm.1910360119
10.1002/1099-1492(200006)13:4<194::AID-NBM643>3.0.CO;2-D
10.1006/jmre.1999.1904
10.1152/japplphysiol.00732.2006
10.1103/PhysRevLett.81.3785
10.1016/j.acra.2007.10.010
10.1002/jmri.20104
10.1016/j.ejrad.2003.10.014
10.1002/mrm.10047
10.1164/ajrccm.155.2.9032213
10.1067/mai.2003.1544
10.1118/1.1833593
10.1148/radiol.2221001834
10.1056/NEJM198102263040906
10.1016/j.jmr.2005.02.016
10.1051/jphys:0198500460120205700
10.1002/cmr.b.20075
10.1002/mrm.20164
10.1016/S0020-7489(01)00060-8
10.1002/bem.10074
10.1056/NEJMoa010043
10.1164/ajrccm.158.6.9608027
10.1119/1.1516383
10.1378/chest.130.3.834
10.1002/mrm.10477
10.1002/cmr.1014
10.1152/japplphysiol.00223.2002
10.1093/ptj/65.5.613
10.1097/00000446-199203000-00010
10.1148/radiology.212.3.r99se20885
10.1002/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4
10.1164/ajrccm.162.2.9905051
10.1002/mrm.20456
10.1002/mrm.10173
10.1002/mrm.1244
10.1152/jappl.1985.59.2.468
10.1002/mrm.20136
10.1177/197140090201500404
10.1002/mrm.10175
10.1152/japplphysiol.01289.2006
10.1164/ajrccm.155.2.9032181
10.1093/bja/aem036
10.1002/jmri.10226
10.1103/RevModPhys.69.629
10.1002/mrm.20576
10.1148/radiology.210.3.r99fe08851
10.1103/PhysRevA.52.862
10.1081/CI-200037034
10.1002/jmri.1880070314
10.1002/mrm.10029
10.1002/jmri.1054
10.1016/S1090-7807(02)00198-2
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Keywords Low magnetic field
Magnetic resonance imaging
Hyperpolarized noble gas
Open access
Lung imaging
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References Ingimarsson, Thorsteinsson, Larsson, Werner (bib19) 2000; 162
Lurie, Li, Petryakov, Zweier (bib61) 2002; 47
Altes, Powers, Knight-Scott, Rakes, Platts-Mills, de Lange, Alford, Mugler, Brookeman (bib14) 2001; 13
Donnelly, MacFall, McAdams, Majure, Smith, Frush, Bogorad, Charles, Ravin (bib13) 1999; 212
Salerno, Altes, Brookeman, de Lange, Mugler (bib5) 2001; 46
Walker, Happer (bib1) 1997; 69
Dean (bib17) 1985; 65
P.S. Morgan, S. Conolly, A. Makovski, Design of uniform field biplanar magnets, in: 5th Meeting of ISMRM, page 1447, Vancouver, Canada (1997).
Gottardi, Mesirca, Agostini, Remondini, Bersani (bib50) 2003; 24
Chatte, Sab, Dubois, Sirodot, Gaussorgues, Robert (bib21) 1997; 155
King, Eberl, Salome, Meikle, Woolcock (bib24) 1997; 155
Wong, Tseng, Pomeroy, Mair, Hinton, Hoffmann, Stoner, Hersman, Cory, Walsworth (bib40) 1999; 141
Parra-Robles, Cross, Santyr (bib41) 2005; 32
Hoult, Richards (bib55) 1976; 24
Deninger, Eberle, Ebert, Grossmann, Hanisch, Heil, Kauczor, Markstaller, Otten, Schreiber, Surkau, Weiler (bib9) 2000; 13
Hoult, Lauterbur (bib52) 1979; 34
Tseng, Wong, Pomeroy, Mair, Hinton, Hoffmann, Stoner, Hersman, Cory, Walsworth (bib39) 1998; 81
Jinkins, Dworkin, Green, Greenhalgh, Gianni, Gelbien, Wolf, Damadian, Damadian (bib29) 2002; 15
Jinkins (bib30) 2004; 50
Wang, Cerny, Kufel, Grant (bib37) 2006; 130
Yablonskiy, Sukstanskii, Ackerman (bib63) 2005; 174
Mure, Lindahl (bib20) 2001; 45
Kim, Rebro, Schmainda (bib54) 2002; 47
Mohoric, Planinsic, Kos, Duh, Stepisnik (bib62) 2004; 32
Leawoods, Yablonskiy, Saam, Gierada, Conradi (bib3) 2001; 13
Rizi, Baumgardner, Ishii, Spector, Edvinsson, Jalali, Yu, Itkin, Lipson, Gefter (bib10) 2004; 52
Darrasse, Guillot, Nacher, Tastevin (bib57) 1997; 324
Musch, Layfield, Harris, Melo, Winkler, Callahan, Fischman, Venegas (bib27) 2002; 93
Fichele, Woodhouse, Swift, Said, Paley, Kasuboski, Mills, van Beek, Wild (bib26) 2004; 20
Bidinosti, Choukeife, Tastevin, Vignaud, Nacher (bib48) 2004; 16
Claasen-Vujcic, Borsboom, Gaykerna, Mehlkopf (bib60) 1996; 36
Callaghan (bib56) 1991
Saam, Happer, Middleton (bib58) 1995; 52
Wild, Paley, Kasuboski, Swift, Fichele, Woodhouse, Griffiths, van Beek (bib6) 2003; 49
Durand, Guillot, Darrasse, Tastevin, Nacher, Vignaud, Vattolo, Bittoun (bib45) 2002; 47
Kim, Hwang, Song (bib22) 2002; 39
Salerno, de Lange, Altes, Truwit, Brookeman, Mugler (bib7) 2002; 222
de Lange, Mugler, Brookeman, Knight-Scott, Truwit, Teates, Daniel, Bogorad, Cates (bib12) 1999; 210
Moller, Chen, Saam, Hagspiel, Johnson, Altes, de Lange, Kauczor (bib4) 2002; 47
E.J.R. van Beek, Lung morphology and function using CT and MRI. in: Proceedings of the Phelinet General Training School: Lung Imaging with Hyperpolarized Helium-3 Magnetic Resonance—from gas production to medical application, Paris, France, January 21–26 (2008).
Wild, Woodhouse, Paley, Fichele, Said, Kasoboski, van Beek (bib53) 2004; 52
Mair, Hrovat, Patz, Rosen, Ruset, Topulos, Tsai, Butler, Hersman, Walsworth (bib42) 2005; 53
Hoffman (bib32) 1985; 59
Yeaw (bib18) 1992; 92
Nacher, Leduc (bib2) 1985; 46
Tsai, Mair, Li, Rosen, Patz, Walsworth (bib31) 2008; 15
Saam, Yablonskiy, Kodibagkar, Leawoods, Gierada, Cooper, Lefrak, Conradi (bib8) 2000; 44
Hopkins, Henderson, Levin, Yamada, Arai, Buxton, Prisk (bib35) 2007; 103
Owers-Bradley, Fichele, Bennattayalah, McGloin, Bowtell, Morgan, Moody (bib44) 2003; 17
Galvin, Drummond, Nirmalan (bib34) 2007; 98
Remolina, Khan, Santiago, Edelman (bib16) 1981; 304
King, Eberl, Salome, Young, Woolcock (bib25) 1998; 158
Petersson, Sanchez-Crespo, Larsson, Mure (bib23) 2007; 102
Ruset, Tsai, Mair, Patz, Hrovat, Rosen, Muradian, Ng, Topulos, Butler, Walsworth, Hersman (bib43) 2006; 29B
Vignaud, Maitre, Guillot, Durand, de Rochefort, Robert, Vives, Santus, Darrasse (bib59) 2005; 54
Gattinoni, Tognoni, Pesenti, Taccone, Mascheroni, Labarta, Malacrida, Di Giulio, Fumagalli, Pelosi, Brazzi, Latini (bib36) 2001; 345
Martin-Du Pan, Benoit, Girardier (bib33) 2004; 134
Chia, Wang (bib51) 2002; 40
Kauczor, Ebert, Kreitner, Nilgens, Surkau, Heil, Hofmann, Otten, Thelen (bib11) 1997; 7
Bidinosti, Choukeife, Nacher, Tastevin (bib47) 2003; 162
Vidal Melo, Layfield, Harris, O+Neill, Musch, Richter, Winkler, Fischman, Venegas (bib28) 2003; 44
Samee, Altes, Powers, de Lange, Knight-Scott, Rakes, Mugler, Ciambotti, Alford, Brookeman, Platts-Mills (bib15) 2003; 111
Venkatesh, Zhang, Mansour, Kubatina, Oh, Blasche, Selim Unlu, Balamore, Jolesz, Goldberg, Albert (bib46) 2003; 21
Hopkins (10.1016/j.jmr.2008.05.016_bib35) 2007; 103
Hoult (10.1016/j.jmr.2008.05.016_bib55) 1976; 24
King (10.1016/j.jmr.2008.05.016_bib24) 1997; 155
Vignaud (10.1016/j.jmr.2008.05.016_bib59) 2005; 54
Hoffman (10.1016/j.jmr.2008.05.016_bib32) 1985; 59
Leawoods (10.1016/j.jmr.2008.05.016_bib3) 2001; 13
Wong (10.1016/j.jmr.2008.05.016_bib40) 1999; 141
Rizi (10.1016/j.jmr.2008.05.016_bib10) 2004; 52
Jinkins (10.1016/j.jmr.2008.05.016_bib30) 2004; 50
Gattinoni (10.1016/j.jmr.2008.05.016_bib36) 2001; 345
Gottardi (10.1016/j.jmr.2008.05.016_bib50) 2003; 24
Callaghan (10.1016/j.jmr.2008.05.016_bib56) 1991
Mure (10.1016/j.jmr.2008.05.016_bib20) 2001; 45
King (10.1016/j.jmr.2008.05.016_bib25) 1998; 158
Saam (10.1016/j.jmr.2008.05.016_bib58) 1995; 52
Bidinosti (10.1016/j.jmr.2008.05.016_bib47) 2003; 162
Mohoric (10.1016/j.jmr.2008.05.016_bib62) 2004; 32
Musch (10.1016/j.jmr.2008.05.016_bib27) 2002; 93
Venkatesh (10.1016/j.jmr.2008.05.016_bib46) 2003; 21
Wild (10.1016/j.jmr.2008.05.016_bib6) 2003; 49
Galvin (10.1016/j.jmr.2008.05.016_bib34) 2007; 98
Jinkins (10.1016/j.jmr.2008.05.016_bib29) 2002; 15
Chia (10.1016/j.jmr.2008.05.016_bib51) 2002; 40
10.1016/j.jmr.2008.05.016_bib49
Remolina (10.1016/j.jmr.2008.05.016_bib16) 1981; 304
Deninger (10.1016/j.jmr.2008.05.016_bib9) 2000; 13
Altes (10.1016/j.jmr.2008.05.016_bib14) 2001; 13
Tsai (10.1016/j.jmr.2008.05.016_bib31) 2008; 15
Nacher (10.1016/j.jmr.2008.05.016_bib2) 1985; 46
Samee (10.1016/j.jmr.2008.05.016_bib15) 2003; 111
Ingimarsson (10.1016/j.jmr.2008.05.016_bib19) 2000; 162
Dean (10.1016/j.jmr.2008.05.016_bib17) 1985; 65
Petersson (10.1016/j.jmr.2008.05.016_bib23) 2007; 102
Mair (10.1016/j.jmr.2008.05.016_bib42) 2005; 53
Fichele (10.1016/j.jmr.2008.05.016_bib26) 2004; 20
Wild (10.1016/j.jmr.2008.05.016_bib53) 2004; 52
Lurie (10.1016/j.jmr.2008.05.016_bib61) 2002; 47
Moller (10.1016/j.jmr.2008.05.016_bib4) 2002; 47
10.1016/j.jmr.2008.05.016_bib38
Salerno (10.1016/j.jmr.2008.05.016_bib7) 2002; 222
Parra-Robles (10.1016/j.jmr.2008.05.016_bib41) 2005; 32
Martin-Du Pan (10.1016/j.jmr.2008.05.016_bib33) 2004; 134
Kim (10.1016/j.jmr.2008.05.016_bib54) 2002; 47
Salerno (10.1016/j.jmr.2008.05.016_bib5) 2001; 46
Wang (10.1016/j.jmr.2008.05.016_bib37) 2006; 130
Durand (10.1016/j.jmr.2008.05.016_bib45) 2002; 47
Darrasse (10.1016/j.jmr.2008.05.016_bib57) 1997; 324
Saam (10.1016/j.jmr.2008.05.016_bib8) 2000; 44
Yeaw (10.1016/j.jmr.2008.05.016_bib18) 1992; 92
Hoult (10.1016/j.jmr.2008.05.016_bib52) 1979; 34
Kauczor (10.1016/j.jmr.2008.05.016_bib11) 1997; 7
Walker (10.1016/j.jmr.2008.05.016_bib1) 1997; 69
de Lange (10.1016/j.jmr.2008.05.016_bib12) 1999; 210
Vidal Melo (10.1016/j.jmr.2008.05.016_bib28) 2003; 44
Claasen-Vujcic (10.1016/j.jmr.2008.05.016_bib60) 1996; 36
Tseng (10.1016/j.jmr.2008.05.016_bib39) 1998; 81
Donnelly (10.1016/j.jmr.2008.05.016_bib13) 1999; 212
Kim (10.1016/j.jmr.2008.05.016_bib22) 2002; 39
Owers-Bradley (10.1016/j.jmr.2008.05.016_bib44) 2003; 17
Bidinosti (10.1016/j.jmr.2008.05.016_bib48) 2004; 16
Chatte (10.1016/j.jmr.2008.05.016_bib21) 1997; 155
Ruset (10.1016/j.jmr.2008.05.016_bib43) 2006; 29B
Yablonskiy (10.1016/j.jmr.2008.05.016_bib63) 2005; 174
References_xml – volume: 15
  start-page: 728
  year: 2008
  end-page: 739
  ident: bib31
  article-title: Posture-dependent human
  publication-title: Acad. Radiol.
– volume: 158
  start-page: 1900
  year: 1998
  end-page: 1906
  ident: bib25
  article-title: Differences in airway closure between normal and asthmatic subjects measured by single-photon emission computed tomography and Technegas
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 46
  start-page: 667
  year: 2001
  end-page: 677
  ident: bib5
  article-title: Dynamic spiral MRI of pulmonary gas flow using hyperpolarized
  publication-title: Magn. Reson. Med.
– volume: 111
  start-page: 1205
  year: 2003
  end-page: 1211
  ident: bib15
  article-title: Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge
  publication-title: J. Allergy Clin. Immunol.
– volume: 155
  start-page: 682
  year: 1997
  end-page: 688
  ident: bib24
  article-title: Airway closure measured by a Technegas bolus and SPECT
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 174
  start-page: 279
  year: 2005
  end-page: 286
  ident: bib63
  article-title: Image artifacts in very low magnetic field MRI: the role of concomitant gradients
  publication-title: J. Magn. Reson.
– volume: 103
  start-page: 240
  year: 2007
  end-page: 248
  ident: bib35
  article-title: Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect
  publication-title: J. Appl. Physiol.
– volume: 50
  start-page: 134
  year: 2004
  end-page: 158
  ident: bib30
  article-title: Acquired degenerative changes of the intervertebral segments at and supradjacent to the lumbosacral junction A radioanatomic analysis of the nondiscal structures of the spinal column and perispinal soft tissues
  publication-title: Eur. J. Radiol.
– volume: 155
  start-page: 473
  year: 1997
  end-page: 478
  ident: bib21
  article-title: Prone position in mechanically ventilated patients with severe acute respiratory failure
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 130
  start-page: 834
  year: 2006
  end-page: 840
  ident: bib37
  article-title: Simulated obesity-related changes in lung volume increases airway responsiveness in lean nonasthmatic subjects
  publication-title: Chest
– volume: 52
  start-page: 65
  year: 2004
  end-page: 72
  ident: bib10
  article-title: Determination of regional
  publication-title: Magn. Reson. Med.
– volume: 54
  start-page: 28
  year: 2005
  end-page: 33
  ident: bib59
  article-title: Magnetic susceptibility matching at the air-tissue interface in rat lung by using a superparamagnetic intravascular contrast agent: Influence on transverse relaxation time of hyperpolarized helium-3
  publication-title: Magn. Reson. Med.
– volume: 17
  start-page: 142
  year: 2003
  end-page: 146
  ident: bib44
  article-title: MR tagging of human lungs using hyperpolarized
  publication-title: J. Magn. Reson. Imaging
– volume: 162
  start-page: 122
  year: 2003
  end-page: 132
  ident: bib47
  article-title: In vivo NMR of hyperpolarized
  publication-title: J. Magn. Reson.
– volume: 24
  start-page: 71
  year: 1976
  end-page: 85
  ident: bib55
  article-title: Signal-to-noise ratio of nuclear magnetic-resonance experiment
  publication-title: J. Magn. Reson.
– volume: 36
  start-page: 111
  year: 1996
  end-page: 116
  ident: bib60
  article-title: Transverse low-field RF coils in MRI
  publication-title: Magn. Reson. Med.
– volume: 13
  start-page: 378
  year: 2001
  end-page: 384
  ident: bib14
  article-title: Hyperpolarized
  publication-title: J. Magn. Reson. Imaging
– volume: 44
  start-page: 1982
  year: 2003
  end-page: 1991
  ident: bib28
  article-title: Quantification of regional ventilation-perfusion ratios with PET
  publication-title: J. Nucl. Med.
– volume: 29B
  start-page: 210
  year: 2006
  end-page: 221
  ident: bib43
  article-title: A system for open-access He-3 human lung imaging at very low field
  publication-title: Concepts Magn. Reson. B—Magn. Reson. Eng.
– volume: 141
  start-page: 217
  year: 1999
  end-page: 227
  ident: bib40
  article-title: A system for low field imaging of laser-polarized noble gas
  publication-title: J. Magn. Reson.
– volume: 32
  start-page: 655
  year: 2004
  end-page: 667
  ident: bib62
  article-title: Magnetic resonance imaging system based on earths magnetic field
  publication-title: Inst. Sci. Tech.
– volume: 52
  start-page: 673
  year: 2004
  end-page: 678
  ident: bib53
  article-title: Comparison between 2D and 3D gradient-echo sequences for MRI of human lung ventilation with hyperpolarized
  publication-title: Magn. Reson. Med.
– volume: 34
  start-page: 425
  year: 1979
  end-page: 433
  ident: bib52
  article-title: The sensitivity of the Zeugmatographic experiment involving human samples
  publication-title: J. Magn. Reson.
– volume: 304
  start-page: 523
  year: 1981
  end-page: 525
  ident: bib16
  article-title: Positional hypoxaemia in unilateral lung disease
  publication-title: N. Engl. J. Med.
– reference: E.J.R. van Beek, Lung morphology and function using CT and MRI. in: Proceedings of the Phelinet General Training School: Lung Imaging with Hyperpolarized Helium-3 Magnetic Resonance—from gas production to medical application, Paris, France, January 21–26 (2008).
– volume: 21
  start-page: 773
  year: 2003
  end-page: 776
  ident: bib46
  article-title: MRI of the lung gas-space at very low-field using hyperpolarized noble gases
  publication-title: Magn. Reson. Imaging
– volume: 210
  start-page: 851
  year: 1999
  end-page: 857
  ident: bib12
  article-title: Lung air spaces: MR imaging evaluation with hyperpolarized
  publication-title: Radiology
– volume: 53
  start-page: 745
  year: 2005
  end-page: 749
  ident: bib42
  publication-title: Magn. Reson. Med.
– volume: 102
  start-page: 468
  year: 2007
  end-page: 476
  ident: bib23
  article-title: Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)
  publication-title: J. Appl. Physiol.
– volume: 59
  start-page: 468
  year: 1985
  end-page: 480
  ident: bib32
  article-title: Effect of body orientation on regional lung expansion: a computed tomographic approach
  publication-title: J. Appl. Physiol.
– volume: 345
  start-page: 568
  year: 2001
  end-page: 573
  ident: bib36
  article-title: Effect of prone positioning on the survival of patients with acute respiratory failure
  publication-title: N. Engl. J. Med.
– volume: 47
  start-page: 75
  year: 2002
  end-page: 81
  ident: bib45
  article-title: CPMG measurements and ultrafast imaging in human lungs with hyperpolarized helium-3 at low field (0.1
  publication-title: Magn. Reson. Med.
– volume: 81
  start-page: 3785
  year: 1998
  end-page: 3788
  ident: bib39
  article-title: Low-field MRI of laser polarized noble gas
  publication-title: Phys. Rev. Lett.
– volume: 47
  start-page: 1110
  year: 2002
  end-page: 1120
  ident: bib54
  article-title: Water exchange and inflow affect the accuracy of T1-GRE blood volume measurements: implications for the evaluation of tumor angiogenesis
  publication-title: Magn. Reson. Med.
– volume: 47
  start-page: 1029
  year: 2002
  end-page: 1051
  ident: bib4
  article-title: MRI of the lungs using hyperpolarized noble gases
  publication-title: Magn. Reson. Med.
– volume: 222
  start-page: 252
  year: 2002
  end-page: 260
  ident: bib7
  article-title: Emphysema: hyperpolarized helium-3 diffusion MR imaging of the lungs compared with spirometric indexes—initial experience
  publication-title: Radiology
– volume: 93
  start-page: 1841
  year: 2002
  end-page: 1851
  ident: bib27
  article-title: Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans
  publication-title: J. Appl. Physiol.
– volume: 49
  start-page: 991
  year: 2003
  end-page: 997
  ident: bib6
  article-title: Dynamic radial projection MRI of inhaled hyperpolarized
  publication-title: Magn. Reson. Med.
– volume: 24
  start-page: 125
  year: 2003
  end-page: 133
  ident: bib50
  article-title: A four coil exposure system (tetracoil) producing a highly uniform magnetic field
  publication-title: Bioelectromagnetics
– volume: 20
  start-page: 331
  year: 2004
  end-page: 335
  ident: bib26
  article-title: MRI of helium-3 gas in healthy lungs: posture related variations of alveolar size
  publication-title: J. Magn. Reson. Imaging
– volume: 44
  start-page: 174
  year: 2000
  end-page: 179
  ident: bib8
  article-title: MR imaging of diffusion of
  publication-title: Magn. Reson. Med.
– volume: 69
  start-page: 629
  year: 1997
  end-page: 642
  ident: bib1
  article-title: Spin-exchange optical pumping of noble-gas nuclei
  publication-title: Rev. Mod. Phys.
– volume: 39
  start-page: 549
  year: 2002
  end-page: 555
  ident: bib22
  article-title: A randomized trial on the effects of body positions on lung function with acute respiratory failure patients
  publication-title: Int. J. Nurs. Stud.
– volume: 15
  start-page: 333
  year: 2002
  end-page: 356
  ident: bib29
  article-title: Upright, weight-bearing, dynamic-kinetic MRI of the Spine pMRI/kMRI
  publication-title: Rivista di Neuroradiologia
– volume: 13
  start-page: 194
  year: 2000
  end-page: 201
  ident: bib9
  publication-title: NMR Biomed.
– volume: 65
  start-page: 613
  year: 1985
  end-page: 618
  ident: bib17
  article-title: Effect of body position on pulmonary function
  publication-title: Phys. Ther.
– year: 1991
  ident: bib56
  article-title: Principles of nuclear magnetic resonance microscopy
– volume: 13
  start-page: 277
  year: 2001
  end-page: 293
  ident: bib3
  article-title: Hyperpolarized He-3 gas production and MR imaging of the lung
  publication-title: Concepts Magn. Reson.
– volume: 134
  start-page: 543
  year: 2004
  end-page: 551
  ident: bib33
  article-title: The role of body position and gravity in the symptoms and treatment of various medical diseases
  publication-title: Swiss Med. Wkly.
– volume: 16
  start-page: 255
  year: 2004
  end-page: 258
  ident: bib48
  article-title: MRI of the lung using hyperpolarized
  publication-title: Magma
– volume: 162
  start-page: 412
  year: 2000
  end-page: 417
  ident: bib19
  article-title: Lung and chest wall mechanics in anesthetized children: influence of body position
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 40
  start-page: 288
  year: 2002
  end-page: 289
  ident: bib51
  article-title: The magnetic field along the axis of a long finite solenoid
  publication-title: The Physics Teacher
– volume: 98
  start-page: 420
  year: 2007
  end-page: 428
  ident: bib34
  article-title: Distribution of blood flow and ventilation in the lung: gravity is not the only factor
  publication-title: Br. J. Anaesth.
– volume: 212
  start-page: 885
  year: 1999
  end-page: 889
  ident: bib13
  article-title: Cystic fibrosis: combined hyperpolarized
  publication-title: Radiology
– volume: 324
  start-page: 691
  year: 1997
  end-page: 700
  ident: bib57
  article-title: Low-field He-3 nuclear magnetic resonance in human lungs
  publication-title: Comptes Rendus De L Academie Des Sciences Serie Ii Fascicule B-Mecanique Physique Chimie Astronomie
– volume: 92
  start-page: 26
  year: 1992
  end-page: 29
  ident: bib18
  article-title: How position affects oxygenation. Good lung down?
  publication-title: Am. J. Nurs.
– volume: 47
  start-page: 181
  year: 2002
  end-page: 186
  ident: bib61
  article-title: Development of a PEDRI free-radical imager using a 0.38
  publication-title: Magn. Reson. Med.
– volume: 32
  start-page: 221
  year: 2005
  end-page: 229
  ident: bib41
  article-title: Theoretical signal-to-noise ratio and spatial resolution dependence on the magnetic field strength for hyperpolarized noble gas magnetic resonance imaging of human lungs
  publication-title: Med. Phys.
– volume: 46
  start-page: 2057
  year: 1985
  end-page: 2073
  ident: bib2
  article-title: Optical-pumping in
  publication-title: J. de Phys.
– reference: P.S. Morgan, S. Conolly, A. Makovski, Design of uniform field biplanar magnets, in: 5th Meeting of ISMRM, page 1447, Vancouver, Canada (1997).
– volume: 7
  start-page: 538
  year: 1997
  end-page: 543
  ident: bib11
  article-title: Imaging of the lungs using
  publication-title: J. Magn. Reson. Imaging
– volume: 52
  start-page: 862
  year: 1995
  end-page: 865
  ident: bib58
  article-title: Nuclear relaxation of
  publication-title: Phys. Rev. A
– volume: 45
  start-page: 150
  year: 2001
  end-page: 159
  ident: bib20
  article-title: Prone position improves gas exchange—but how?
  publication-title: Acta Anaesthesiol. Scand.
– year: 1991
  ident: 10.1016/j.jmr.2008.05.016_bib56
– volume: 21
  start-page: 773
  issue: 7
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib46
  article-title: MRI of the lung gas-space at very low-field using hyperpolarized noble gases
  publication-title: Magn. Reson. Imaging
  doi: 10.1016/S0730-725X(03)00178-4
– volume: 16
  start-page: 255
  issue: 6
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib48
  article-title: MRI of the lung using hyperpolarized 3He at very low magnetic field (3mT)
  publication-title: Magma
  doi: 10.1007/s10334-004-0035-y
– volume: 36
  start-page: 111
  year: 1996
  ident: 10.1016/j.jmr.2008.05.016_bib60
  article-title: Transverse low-field RF coils in MRI
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910360119
– volume: 13
  start-page: 194
  issue: 4
  year: 2000
  ident: 10.1016/j.jmr.2008.05.016_bib9
  article-title: 3He-MRI-based measurements of intrapulmonary pO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations
  publication-title: NMR Biomed.
  doi: 10.1002/1099-1492(200006)13:4<194::AID-NBM643>3.0.CO;2-D
– volume: 34
  start-page: 425
  issue: 2
  year: 1979
  ident: 10.1016/j.jmr.2008.05.016_bib52
  article-title: The sensitivity of the Zeugmatographic experiment involving human samples
  publication-title: J. Magn. Reson.
– volume: 141
  start-page: 217
  issue: 2
  year: 1999
  ident: 10.1016/j.jmr.2008.05.016_bib40
  article-title: A system for low field imaging of laser-polarized noble gas
  publication-title: J. Magn. Reson.
  doi: 10.1006/jmre.1999.1904
– volume: 102
  start-page: 468
  year: 2007
  ident: 10.1016/j.jmr.2008.05.016_bib23
  article-title: Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00732.2006
– volume: 81
  start-page: 3785
  issue: 17
  year: 1998
  ident: 10.1016/j.jmr.2008.05.016_bib39
  article-title: Low-field MRI of laser polarized noble gas
  publication-title: Phys. Rev. Lett.
  doi: 10.1103/PhysRevLett.81.3785
– volume: 15
  start-page: 728
  issue: 6
  year: 2008
  ident: 10.1016/j.jmr.2008.05.016_bib31
  article-title: Posture-dependent human 3He lung imaging in an open access MRI system: initial results
  publication-title: Acad. Radiol.
  doi: 10.1016/j.acra.2007.10.010
– volume: 20
  start-page: 331
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib26
  article-title: MRI of helium-3 gas in healthy lungs: posture related variations of alveolar size
  publication-title: J. Magn. Reson. Imaging
  doi: 10.1002/jmri.20104
– volume: 134
  start-page: 543
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib33
  article-title: The role of body position and gravity in the symptoms and treatment of various medical diseases
  publication-title: Swiss Med. Wkly.
– volume: 50
  start-page: 134
  issue: 1
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib30
  article-title: Acquired degenerative changes of the intervertebral segments at and supradjacent to the lumbosacral junction A radioanatomic analysis of the nondiscal structures of the spinal column and perispinal soft tissues
  publication-title: Eur. J. Radiol.
  doi: 10.1016/j.ejrad.2003.10.014
– volume: 47
  start-page: 75
  issue: 1
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib45
  article-title: CPMG measurements and ultrafast imaging in human lungs with hyperpolarized helium-3 at low field (0.1T)
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.10047
– volume: 155
  start-page: 682
  year: 1997
  ident: 10.1016/j.jmr.2008.05.016_bib24
  article-title: Airway closure measured by a Technegas bolus and SPECT
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.155.2.9032213
– volume: 324
  start-page: 691
  issue: 11
  year: 1997
  ident: 10.1016/j.jmr.2008.05.016_bib57
  article-title: Low-field He-3 nuclear magnetic resonance in human lungs
  publication-title: Comptes Rendus De L Academie Des Sciences Serie Ii Fascicule B-Mecanique Physique Chimie Astronomie
– volume: 44
  start-page: 1982
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib28
  article-title: Quantification of regional ventilation-perfusion ratios with PET
  publication-title: J. Nucl. Med.
– volume: 111
  start-page: 1205
  issue: 1
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib15
  article-title: Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1067/mai.2003.1544
– volume: 32
  start-page: 221
  issue: 1
  year: 2005
  ident: 10.1016/j.jmr.2008.05.016_bib41
  article-title: Theoretical signal-to-noise ratio and spatial resolution dependence on the magnetic field strength for hyperpolarized noble gas magnetic resonance imaging of human lungs
  publication-title: Med. Phys.
  doi: 10.1118/1.1833593
– volume: 222
  start-page: 252
  issue: 1
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib7
  article-title: Emphysema: hyperpolarized helium-3 diffusion MR imaging of the lungs compared with spirometric indexes—initial experience
  publication-title: Radiology
  doi: 10.1148/radiol.2221001834
– volume: 304
  start-page: 523
  year: 1981
  ident: 10.1016/j.jmr.2008.05.016_bib16
  article-title: Positional hypoxaemia in unilateral lung disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM198102263040906
– volume: 174
  start-page: 279
  issue: 2
  year: 2005
  ident: 10.1016/j.jmr.2008.05.016_bib63
  article-title: Image artifacts in very low magnetic field MRI: the role of concomitant gradients
  publication-title: J. Magn. Reson.
  doi: 10.1016/j.jmr.2005.02.016
– volume: 46
  start-page: 2057
  issue: 12
  year: 1985
  ident: 10.1016/j.jmr.2008.05.016_bib2
  article-title: Optical-pumping in 3He with a laser
  publication-title: J. de Phys.
  doi: 10.1051/jphys:0198500460120205700
– volume: 29B
  start-page: 210
  issue: 4
  year: 2006
  ident: 10.1016/j.jmr.2008.05.016_bib43
  article-title: A system for open-access He-3 human lung imaging at very low field
  publication-title: Concepts Magn. Reson. B—Magn. Reson. Eng.
  doi: 10.1002/cmr.b.20075
– ident: 10.1016/j.jmr.2008.05.016_bib38
– volume: 52
  start-page: 673
  issue: 4
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib53
  article-title: Comparison between 2D and 3D gradient-echo sequences for MRI of human lung ventilation with hyperpolarized 3He
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.20164
– volume: 39
  start-page: 549
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib22
  article-title: A randomized trial on the effects of body positions on lung function with acute respiratory failure patients
  publication-title: Int. J. Nurs. Stud.
  doi: 10.1016/S0020-7489(01)00060-8
– volume: 24
  start-page: 125
  issue: 2
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib50
  article-title: A four coil exposure system (tetracoil) producing a highly uniform magnetic field
  publication-title: Bioelectromagnetics
  doi: 10.1002/bem.10074
– volume: 345
  start-page: 568
  year: 2001
  ident: 10.1016/j.jmr.2008.05.016_bib36
  article-title: Effect of prone positioning on the survival of patients with acute respiratory failure
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa010043
– volume: 158
  start-page: 1900
  year: 1998
  ident: 10.1016/j.jmr.2008.05.016_bib25
  article-title: Differences in airway closure between normal and asthmatic subjects measured by single-photon emission computed tomography and Technegas
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.158.6.9608027
– volume: 40
  start-page: 288
  issue: 5
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib51
  article-title: The magnetic field along the axis of a long finite solenoid
  publication-title: The Physics Teacher
  doi: 10.1119/1.1516383
– volume: 45
  start-page: 150
  year: 2001
  ident: 10.1016/j.jmr.2008.05.016_bib20
  article-title: Prone position improves gas exchange—but how?
  publication-title: Acta Anaesthesiol. Scand.
– volume: 130
  start-page: 834
  year: 2006
  ident: 10.1016/j.jmr.2008.05.016_bib37
  article-title: Simulated obesity-related changes in lung volume increases airway responsiveness in lean nonasthmatic subjects
  publication-title: Chest
  doi: 10.1378/chest.130.3.834
– ident: 10.1016/j.jmr.2008.05.016_bib49
– volume: 49
  start-page: 991
  issue: 6
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib6
  article-title: Dynamic radial projection MRI of inhaled hyperpolarized 3He gas
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.10477
– volume: 13
  start-page: 277
  issue: 5
  year: 2001
  ident: 10.1016/j.jmr.2008.05.016_bib3
  article-title: Hyperpolarized He-3 gas production and MR imaging of the lung
  publication-title: Concepts Magn. Reson.
  doi: 10.1002/cmr.1014
– volume: 93
  start-page: 1841
  issue: 5
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib27
  article-title: Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00223.2002
– volume: 65
  start-page: 613
  year: 1985
  ident: 10.1016/j.jmr.2008.05.016_bib17
  article-title: Effect of body position on pulmonary function
  publication-title: Phys. Ther.
  doi: 10.1093/ptj/65.5.613
– volume: 92
  start-page: 26
  year: 1992
  ident: 10.1016/j.jmr.2008.05.016_bib18
  article-title: How position affects oxygenation. Good lung down?
  publication-title: Am. J. Nurs.
  doi: 10.1097/00000446-199203000-00010
– volume: 212
  start-page: 885
  issue: 3
  year: 1999
  ident: 10.1016/j.jmr.2008.05.016_bib13
  article-title: Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung—preliminary observations
  publication-title: Radiology
  doi: 10.1148/radiology.212.3.r99se20885
– volume: 44
  start-page: 174
  issue: 2
  year: 2000
  ident: 10.1016/j.jmr.2008.05.016_bib8
  article-title: MR imaging of diffusion of 3He gas in healthy and diseased lungs
  publication-title: Magn. Reson. Med.
  doi: 10.1002/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4
– volume: 162
  start-page: 412
  year: 2000
  ident: 10.1016/j.jmr.2008.05.016_bib19
  article-title: Lung and chest wall mechanics in anesthetized children: influence of body position
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.162.2.9905051
– volume: 53
  start-page: 745
  issue: 4
  year: 2005
  ident: 10.1016/j.jmr.2008.05.016_bib42
  article-title: 3He lung imaging in an open access, very-low-field human magnetic resonance imaging system
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.20456
– volume: 47
  start-page: 1029
  issue: 6
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib4
  article-title: MRI of the lungs using hyperpolarized noble gases
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.10173
– volume: 46
  start-page: 667
  issue: 4
  year: 2001
  ident: 10.1016/j.jmr.2008.05.016_bib5
  article-title: Dynamic spiral MRI of pulmonary gas flow using hyperpolarized 3He: preliminary studies in healthy and diseased lungs
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1244
– volume: 59
  start-page: 468
  year: 1985
  ident: 10.1016/j.jmr.2008.05.016_bib32
  article-title: Effect of body orientation on regional lung expansion: a computed tomographic approach
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1985.59.2.468
– volume: 52
  start-page: 65
  issue: 1
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib10
  article-title: Determination of regional VA/Q by hyperpolarized 3He MRI
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.20136
– volume: 15
  start-page: 333
  issue: 1
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib29
  article-title: Upright, weight-bearing, dynamic-kinetic MRI of the Spine pMRI/kMRI
  publication-title: Rivista di Neuroradiologia
  doi: 10.1177/197140090201500404
– volume: 47
  start-page: 1110
  issue: 6
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib54
  article-title: Water exchange and inflow affect the accuracy of T1-GRE blood volume measurements: implications for the evaluation of tumor angiogenesis
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.10175
– volume: 103
  start-page: 240
  year: 2007
  ident: 10.1016/j.jmr.2008.05.016_bib35
  article-title: Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.01289.2006
– volume: 155
  start-page: 473
  year: 1997
  ident: 10.1016/j.jmr.2008.05.016_bib21
  article-title: Prone position in mechanically ventilated patients with severe acute respiratory failure
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.155.2.9032181
– volume: 98
  start-page: 420
  year: 2007
  ident: 10.1016/j.jmr.2008.05.016_bib34
  article-title: Distribution of blood flow and ventilation in the lung: gravity is not the only factor
  publication-title: Br. J. Anaesth.
  doi: 10.1093/bja/aem036
– volume: 17
  start-page: 142
  issue: 1
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib44
  article-title: MR tagging of human lungs using hyperpolarized 3He gas
  publication-title: J. Magn. Reson. Imaging
  doi: 10.1002/jmri.10226
– volume: 69
  start-page: 629
  issue: 2
  year: 1997
  ident: 10.1016/j.jmr.2008.05.016_bib1
  article-title: Spin-exchange optical pumping of noble-gas nuclei
  publication-title: Rev. Mod. Phys.
  doi: 10.1103/RevModPhys.69.629
– volume: 54
  start-page: 28
  issue: 1
  year: 2005
  ident: 10.1016/j.jmr.2008.05.016_bib59
  article-title: Magnetic susceptibility matching at the air-tissue interface in rat lung by using a superparamagnetic intravascular contrast agent: Influence on transverse relaxation time of hyperpolarized helium-3
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.20576
– volume: 210
  start-page: 851
  issue: 3
  year: 1999
  ident: 10.1016/j.jmr.2008.05.016_bib12
  article-title: Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas
  publication-title: Radiology
  doi: 10.1148/radiology.210.3.r99fe08851
– volume: 24
  start-page: 71
  issue: 1
  year: 1976
  ident: 10.1016/j.jmr.2008.05.016_bib55
  article-title: Signal-to-noise ratio of nuclear magnetic-resonance experiment
  publication-title: J. Magn. Reson.
– volume: 52
  start-page: 862
  issue: 1
  year: 1995
  ident: 10.1016/j.jmr.2008.05.016_bib58
  article-title: Nuclear relaxation of 3He in the presence of O2
  publication-title: Phys. Rev. A
  doi: 10.1103/PhysRevA.52.862
– volume: 32
  start-page: 655
  issue: 6
  year: 2004
  ident: 10.1016/j.jmr.2008.05.016_bib62
  article-title: Magnetic resonance imaging system based on earths magnetic field
  publication-title: Inst. Sci. Tech.
  doi: 10.1081/CI-200037034
– volume: 7
  start-page: 538
  issue: 1
  year: 1997
  ident: 10.1016/j.jmr.2008.05.016_bib11
  article-title: Imaging of the lungs using 3He MRI: preliminary clinical experience in 18 patients with and without lung disease
  publication-title: J. Magn. Reson. Imaging
  doi: 10.1002/jmri.1880070314
– volume: 47
  start-page: 181
  year: 2002
  ident: 10.1016/j.jmr.2008.05.016_bib61
  article-title: Development of a PEDRI free-radical imager using a 0.38T clinical MRI system
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.10029
– volume: 13
  start-page: 378
  issue: 3
  year: 2001
  ident: 10.1016/j.jmr.2008.05.016_bib14
  article-title: Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings
  publication-title: J. Magn. Reson. Imaging
  doi: 10.1002/jmri.1054
– volume: 162
  start-page: 122
  issue: 1
  year: 2003
  ident: 10.1016/j.jmr.2008.05.016_bib47
  article-title: In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields
  publication-title: J. Magn. Reson.
  doi: 10.1016/S1090-7807(02)00198-2
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Snippet We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the...
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the...
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in-vivo hyperpolarized 3 He imaging of the...
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StartPage 274
SubjectTerms Equipment Design
Equipment Failure Analysis
Helium
Humans
Hyperpolarized noble gas
Image Enhancement - instrumentation
Image Interpretation, Computer-Assisted - instrumentation
Imaging, Three-Dimensional - instrumentation
Isotopes
Low magnetic field
Lung - anatomy & histology
Lung imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - instrumentation
Open access
Posture
Transducers
Title An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging
URI https://dx.doi.org/10.1016/j.jmr.2008.05.016
https://www.ncbi.nlm.nih.gov/pubmed/18550402
https://www.proquest.com/docview/69357927
https://pubmed.ncbi.nlm.nih.gov/PMC2572034
Volume 193
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