Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: Current knowledge and future directions

• Published in: Alzheimer's & dementia Vol. 19; no. 2; pp. 532 - 548
• Main Authors: Weijs, Ralf W.J., Shkredova, Daria A., Brekelmans, Anna C.M., Thijssen, Dick H.J., Claassen, Jurgen A.H.R.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2023
• Subjects: Alzheimer Disease; Alzheimer's disease; cerebrovascular circulation; Cerebrovascular Circulation - physiology; cognition; Cognitive Dysfunction; Cross-Sectional Studies; dementia; Humans; Longitudinal Studies; meta‐analysis; single‐photon emission computed tomography; systematic review; cerebrovascular circulation; cognition; meta-analysis; dementia; systematic review; Alzheimer's disease; single-photon emission computed tomography

The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. C...