Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: Current knowledge and future directions
The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. C...
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| Published in | Alzheimer's & dementia Vol. 19; no. 2; pp. 532 - 548 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.02.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1552-5260 1552-5279 1552-5279 |
| DOI | 10.1002/alz.12666 |
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| Abstract | The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. Cross‐sectional studies demonstrate lower CBF in patients with cognitive decline compared to healthy age‐matched peers. Remarkably, longitudinal studies do not support a link between CBF reductions and cognitive decline. These studies, however, are often limited by small sample sizes and may therefore be underpowered to detect small effect sizes. Therefore, through a systematic review and meta‐analysis of longitudinal studies, we examined whether longitudinal changes in global CBF are related to cognitive decline in subjects with Alzheimer's disease, and qualitatively described findings on regional CBF. Considering the growing impact of dementia and the lack of treatment options, it is important to understand the role of CBF as a prognostic biomarker and/or treatment target in dementia. |
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| AbstractList | The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. Cross-sectional studies demonstrate lower CBF in patients with cognitive decline compared to healthy age-matched peers. Remarkably, longitudinal studies do not support a link between CBF reductions and cognitive decline. These studies, however, are often limited by small sample sizes and may therefore be underpowered to detect small effect sizes. Therefore, through a systematic review and meta-analysis of longitudinal studies, we examined whether longitudinal changes in global CBF are related to cognitive decline in subjects with Alzheimer's disease, and qualitatively described findings on regional CBF. Considering the growing impact of dementia and the lack of treatment options, it is important to understand the role of CBF as a prognostic biomarker and/or treatment target in dementia. The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. Cross-sectional studies demonstrate lower CBF in patients with cognitive decline compared to healthy age-matched peers. Remarkably, longitudinal studies do not support a link between CBF reductions and cognitive decline. These studies, however, are often limited by small sample sizes and may therefore be underpowered to detect small effect sizes. Therefore, through a systematic review and meta-analysis of longitudinal studies, we examined whether longitudinal changes in global CBF are related to cognitive decline in subjects with Alzheimer's disease, and qualitatively described findings on regional CBF. Considering the growing impact of dementia and the lack of treatment options, it is important to understand the role of CBF as a prognostic biomarker and/or treatment target in dementia.The pathophysiology underlying cognitive decline is multifactorial, with increasing literature suggesting a role for cerebrovascular health. Cerebral blood flow (CBF) is an important element of cerebrovascular health, which raises questions regarding the relation between CBF and cognitive decline. Cross-sectional studies demonstrate lower CBF in patients with cognitive decline compared to healthy age-matched peers. Remarkably, longitudinal studies do not support a link between CBF reductions and cognitive decline. These studies, however, are often limited by small sample sizes and may therefore be underpowered to detect small effect sizes. Therefore, through a systematic review and meta-analysis of longitudinal studies, we examined whether longitudinal changes in global CBF are related to cognitive decline in subjects with Alzheimer's disease, and qualitatively described findings on regional CBF. Considering the growing impact of dementia and the lack of treatment options, it is important to understand the role of CBF as a prognostic biomarker and/or treatment target in dementia. |
| Author | Claassen, Jurgen A.H.R. Shkredova, Daria A. Thijssen, Dick H.J. Brekelmans, Anna C.M. Weijs, Ralf W.J. |
| Author_xml | – sequence: 1 givenname: Ralf W.J. orcidid: 0000-0003-4150-7345 surname: Weijs fullname: Weijs, Ralf W.J. organization: Radboud University Medical Center – sequence: 2 givenname: Daria A. surname: Shkredova fullname: Shkredova, Daria A. organization: University of British Columbia Okanagan – sequence: 3 givenname: Anna C.M. surname: Brekelmans fullname: Brekelmans, Anna C.M. organization: Radboud University Medical Center – sequence: 4 givenname: Dick H.J. surname: Thijssen fullname: Thijssen, Dick H.J. organization: Liverpool John Moores University – sequence: 5 givenname: Jurgen A.H.R. surname: Claassen fullname: Claassen, Jurgen A.H.R. email: Jurgen.Claassen@radboudumc.nl organization: Radboud University Medical Center |
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| Copyright | 2022 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association. 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. |
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| Keywords | cerebrovascular circulation cognition meta-analysis dementia systematic review Alzheimer's disease single-photon emission computed tomography |
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| Notes | Dick H.J. Thijssen and Jurgen A.H.R. Claassen contributed equally as senior authors. SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Undefined-1 content type line 23 ObjectType-Article-3 |
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| SubjectTerms | Alzheimer Disease Alzheimer's disease cerebrovascular circulation Cerebrovascular Circulation - physiology cognition Cognitive Dysfunction Cross-Sectional Studies dementia Humans Longitudinal Studies meta‐analysis single‐photon emission computed tomography systematic review |
| Title | Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: Current knowledge and future directions |
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