Disruption and overexpression of 6-phosphofructo-2-kinase influence organic acid production in Aspergillus carbonarius ITEM 5010
Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene f2kp encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in...
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| Published in | World journal of microbiology & biotechnology Vol. 36; no. 7; p. 98 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.07.2020
Springer Nature B.V |
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| Online Access | Get full text |
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| Abstract | Aspergillus carbonarius
is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene
f2kp
encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in the production of organic acid. The strategy was to examine the impact of citric acid and malic acid production by overexpressing and disrupting
f2kp
, respectively. The overexpressing transformants expressed
f2kp
at higher level than the wild type, whereas no expression of
f2kp
was detected in the knockout transformants. Citric acid and malic acid production by the knockout strains decreased sharply along with a significant lower sugar consumption, though the overexpressing transformants produced similar amounts of citric acid and malic acid as the wild type. We conclude that 6-phosphofructo-2-kinase has an important regulatory role for the glycolytic flux and organic acid production in
A. carbonarius. |
|---|---|
| AbstractList | Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene f2kp encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in the production of organic acid. The strategy was to examine the impact of citric acid and malic acid production by overexpressing and disrupting f2kp, respectively. The overexpressing transformants expressed f2kp at higher level than the wild type, whereas no expression of f2kp was detected in the knockout transformants. Citric acid and malic acid production by the knockout strains decreased sharply along with a significant lower sugar consumption, though the overexpressing transformants produced similar amounts of citric acid and malic acid as the wild type. We conclude that 6-phosphofructo-2-kinase has an important regulatory role for the glycolytic flux and organic acid production in A. carbonarius.Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene f2kp encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in the production of organic acid. The strategy was to examine the impact of citric acid and malic acid production by overexpressing and disrupting f2kp, respectively. The overexpressing transformants expressed f2kp at higher level than the wild type, whereas no expression of f2kp was detected in the knockout transformants. Citric acid and malic acid production by the knockout strains decreased sharply along with a significant lower sugar consumption, though the overexpressing transformants produced similar amounts of citric acid and malic acid as the wild type. We conclude that 6-phosphofructo-2-kinase has an important regulatory role for the glycolytic flux and organic acid production in A. carbonarius. Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene f2kp encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in the production of organic acid. The strategy was to examine the impact of citric acid and malic acid production by overexpressing and disrupting f2kp, respectively. The overexpressing transformants expressed f2kp at higher level than the wild type, whereas no expression of f2kp was detected in the knockout transformants. Citric acid and malic acid production by the knockout strains decreased sharply along with a significant lower sugar consumption, though the overexpressing transformants produced similar amounts of citric acid and malic acid as the wild type. We conclude that 6-phosphofructo-2-kinase has an important regulatory role for the glycolytic flux and organic acid production in A. carbonarius. Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified a gene f2kp encoding the enzyme 6-phosphofructo-2-kinase known as an allosteric regulator of the glycolytic flux and investigated its role in the production of organic acid. The strategy was to examine the impact of citric acid and malic acid production by overexpressing and disrupting f2kp , respectively. The overexpressing transformants expressed f2kp at higher level than the wild type, whereas no expression of f2kp was detected in the knockout transformants. Citric acid and malic acid production by the knockout strains decreased sharply along with a significant lower sugar consumption, though the overexpressing transformants produced similar amounts of citric acid and malic acid as the wild type. We conclude that 6-phosphofructo-2-kinase has an important regulatory role for the glycolytic flux and organic acid production in A. carbonarius. |
| ArticleNumber | 98 |
| Author | Yang, Lei Nilsson, Lena Lübeck, Peter S. Ahring, Birgitte K. Lübeck, Mette Bruno, Kenneth S. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32601748$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.mimet.2013.10.018 10.1080/21655979.2015.1111493 10.1186/s12934-016-0623-3 10.1016/B978-0-12-418687-3.00011-2 10.1007/978-1-4419-8859-1_12 10.1016/0304-4165(90)90128-J 10.1016/j.fbr.2016.11.001 10.1042/bj2090669 10.1016/j.biotechadv.2007.01.002 10.1186/s13568-014-0054-7 10.1007/s00253-018-8818-7 10.1128/AEM.71.3.1425-1432.2005 10.1002/biof.5520100101 10.1016/j.jbiotec.2009.04.004 10.1007/s11274-016-2025-4 10.1016/B978-0-12-416618-9.00005-4 10.1007/978-1-60761-723-5_13 10.1007/s10295-014-1415-6 10.1007/s10295-015-1688-4 10.1007/s00253-001-0839-x 10.1128/AEM.00539-06 |
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| Keywords | 6-Phosphofructo-2-kinase Citric acid Organic acids Aspergillus carbonarius |
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is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified... Aspergillus carbonarius is an efficient producer of organic acids with great potential for bio-based production of organic acids. In this study, we identified... |
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| SubjectTerms | 6-Phosphofructo-2-kinase Acid production Acids Acids - metabolism Allosteric properties Applied Microbiology Aspergillus - enzymology Aspergillus - genetics Aspergillus - metabolism Aspergillus carbonarius Biochemistry Biomedical and Life Sciences Biotechnology Citric acid Citric Acid - metabolism Disruption Environmental Engineering/Biotechnology Gene Expression Regulation, Fungal Gene Knockout Techniques genes Genes, Fungal - genetics Glycolysis Kinases Life Sciences Malates - metabolism Malic acid Microbiology Organic acids Organic Chemicals - metabolism Original Paper Phosphofructokinase-2 - genetics Phosphofructokinase-2 - metabolism sugars Transcriptome |
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| Title | Disruption and overexpression of 6-phosphofructo-2-kinase influence organic acid production in Aspergillus carbonarius ITEM 5010 |
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