To be, or not to be: functional dilemma of p53 metabolic regulation

In recent years, the emerging role of p53 in metabolic regulation has been a topic of great interest. Although apoptotic and growth arrest functions of p53 remain as important mechanisms for preserving genomic stability, metabolic functions of p53 show increasing potential in contributing to p53-med...

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Published inCurrent opinion in oncology Vol. 26; no. 1; p. 78
Main Authors Wang, Shang-Jui, Gu, Wei
Format Journal Article
LanguageEnglish
Published United States 01.01.2014
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Abstract In recent years, the emerging role of p53 in metabolic regulation has been a topic of great interest. Although apoptotic and growth arrest functions of p53 remain as important mechanisms for preserving genomic stability, metabolic functions of p53 show increasing potential in contributing to p53-mediated tumor suppression. Numerous recent studies provided further insights into the metabolic functions of p53 and their implications in tumorigenesis. Several novel p53 metabolic targets have been identified that participate in various aspects of metabolism. Although some studies demonstrate the potential tumor suppressive function of p53 metabolic genes, others reveal prosurvival roles of those targets in both tumor and normal cells. Specifically, Tp53-induced glycolysis and apoptosis regulator (TIGAR) has been thought to promote tumor suppression through metabolic fine-tuning, yet, TIGAR-deficient mice display reduction in tumorigenesis. Finally, characterization of the 3KR mouse model underscored the significance of p53 metabolic regulation in tumor suppression, while also alluding to the potential mechanism for selective regulation of p53 metabolic targets. Expression of many p53 metabolic genes elicits both antitumor and tumorigenic effects, suggesting that p53 may contribute to cellular protection as well as tumor suppression. Future studies must carefully dissect the duality of p53 metabolic function, which may potentially prove useful in designing cancer therapies.
AbstractList In recent years, the emerging role of p53 in metabolic regulation has been a topic of great interest. Although apoptotic and growth arrest functions of p53 remain as important mechanisms for preserving genomic stability, metabolic functions of p53 show increasing potential in contributing to p53-mediated tumor suppression. Numerous recent studies provided further insights into the metabolic functions of p53 and their implications in tumorigenesis. Several novel p53 metabolic targets have been identified that participate in various aspects of metabolism. Although some studies demonstrate the potential tumor suppressive function of p53 metabolic genes, others reveal prosurvival roles of those targets in both tumor and normal cells. Specifically, Tp53-induced glycolysis and apoptosis regulator (TIGAR) has been thought to promote tumor suppression through metabolic fine-tuning, yet, TIGAR-deficient mice display reduction in tumorigenesis. Finally, characterization of the 3KR mouse model underscored the significance of p53 metabolic regulation in tumor suppression, while also alluding to the potential mechanism for selective regulation of p53 metabolic targets. Expression of many p53 metabolic genes elicits both antitumor and tumorigenic effects, suggesting that p53 may contribute to cellular protection as well as tumor suppression. Future studies must carefully dissect the duality of p53 metabolic function, which may potentially prove useful in designing cancer therapies.
Author Gu, Wei
Wang, Shang-Jui
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References 19410540 - Cell. 2009 May 1;137(3):413-31
19776744 - Nat Rev Cancer. 2009 Oct;9(10):749-58
18056705 - J Biol Chem. 2008 Feb 15;283(7):3979-87
21930938 - Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16259-64
17189187 - Mol Cell. 2006 Dec 28;24(6):841-51
17143283 - Nat Genet. 2007 Jan;39(1):99-105
22055193 - Mol Cell. 2011 Nov 4;44(3):491-501
11099028 - Nature. 2000 Nov 16;408(6810):307-10
15059920 - Cancer Res. 2004 Apr 1;64(7):2627-33
20351271 - Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7461-6
21258394 - Nat Rev Cancer. 2011 Feb;11(2):85-95
23343762 - Cell Cycle. 2013 Mar 1;12(5):753-61
23665218 - Cell Rep. 2013 May 30;3(5):1339-45
16766262 - Cancer Cell. 2006 Jun;9(6):425-34
21042727 - Int J Oncol. 2010 Dec;37(6):1575-81
18259198 - Cell Death Differ. 2008 Jun;15(6):1019-29
19478820 - Nat Rev Drug Discov. 2009 Jul;8(7):579-91
21734707 - Nature. 2011 Jul 7;475(7354):106-9
23726973 - Dev Cell. 2013 Jun 10;25(5):463-77
12154352 - Nat Rev Cancer. 2002 Aug;2(8):594-604
16483932 - Mol Cell. 2006 Feb 17;21(4):509-19
15231669 - Cancer Res. 2004 Jul 1;64(13):4577-84
16839880 - Cell. 2006 Jul 14;126(1):107-20
1614522 - Nature. 1992 Jul 2;358(6381):15-6
9039259 - Cell. 1997 Feb 7;88(3):323-31
9205063 - Cancer Res. 1997 Jul 1;57(13):2602-5
21765468 - Oncogene. 2012 Mar 1;31(9):1166-75
23334421 - Nature. 2013 Jan 31;493(7434):689-93
20832749 - Cancer Cell. 2010 Sep 14;18(3):207-19
21340684 - J Mol Med (Berl). 2011 Mar;89(3):237-45
20975668 - Nat Commun. 2010;1:5
22887998 - J Biol Chem. 2012 Sep 28;287(40):33436-46
22682249 - Cell. 2012 Jun 8;149(6):1269-83
22120717 - Oncogene. 2012 Aug 16;31(33):3764-76
18485870 - Cell. 2008 May 16;133(4):612-26
23242140 - Nature. 2013 Jan 24;493(7433):542-6
22499945 - Science. 2012 Apr 13;336(6078):225-8
15866171 - Mol Cell. 2005 Apr 29;18(3):283-93
18391940 - Nat Cell Biol. 2008 May;10(5):611-8
20559429 - PLoS One. 2010;5(6):e11107
18337823 - Nature. 2008 Mar 13;452(7184):230-3
13298683 - Science. 1956 Feb 24;123(3191):309-14
10401564 - Br J Pharmacol. 1999 Jun;127(3):729-39
23603120 - Mol Cell. 2013 May 9;50(3):394-406
19460998 - Science. 2009 May 22;324(5930):1029-33
18775299 - Cell. 2008 Sep 5;134(5):703-7
16959615 - Cancer Cell. 2006 Sep;10(3):241-52
20378837 - Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60
22117613 - Antioxid Redox Signal. 2012 Jun 1;16(11):1285-94
21820150 - Hum Pathol. 2012 Feb;43(2):221-8
17189186 - Mol Cell. 2006 Dec 28;24(6):827-39
20066118 - Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a001883
16728594 - Science. 2006 Jun 16;312(5780):1650-3
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SubjectTerms Carcinogenesis - genetics
Carcinogenesis - metabolism
Energy Metabolism - physiology
Gene Expression
Genes, p53
Glycolysis
Humans
Tumor Suppressor Protein p53 - metabolism
Title To be, or not to be: functional dilemma of p53 metabolic regulation
URI https://www.ncbi.nlm.nih.gov/pubmed/24240177
Volume 26
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