Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial
The number of studies devoted to the scientific evaluation of phytotherapy is rapidly increasing since Western patients seem more oriented towards so‐called ‘alternative medicine’. Bearing such arguments in mind we decided to address attention to Eleutherococcus senticosus, a root of the Ginseng fam...
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| Published in | Stress and health Vol. 18; no. 1; pp. 11 - 17 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.02.2002
Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1532-3005 1532-2998 |
| DOI | 10.1002/smi.914 |
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| Abstract | The number of studies devoted to the scientific evaluation of phytotherapy is rapidly increasing since Western patients seem more oriented towards so‐called ‘alternative medicine’. Bearing such arguments in mind we decided to address attention to Eleutherococcus senticosus, a root of the Ginseng family known for thousands of years in China as a remedy for psychological distress. Forty‐five paid, healthy volunteers (20 males, 25 females) were recruited. Entry criteria were: good health, age 18–30 years, student and a Symptoms Rating Test score <10. At screening evaluation subjects were randomized to receive orally either placebo (Pl group) or Eleutherococcus senticosus (Es group) for 30 days, in a double‐blind design. Subjects were submitted to a stressful cognitive task, the Stroop Colour–Word test (Stroop CW), both before and after treatment. Stroop CW increased heart rate (HR) and systolic BP in every subject. In females there was a greater response than in males in terms of both systolic and diastolic BP. For both genders, the HR response to Stroop CW was reduced by Es treatment while no changes were found after Pl. In females, systolic BP was also reduced in Es group while it remained unchanged in Pl group. This study demonstrated that treatment with Eleutherococcus senticosus is able to reduce cardiovascular responses to stress in healthy young volunteers, while placebo was ineffective. Eleutherococcus senticosus is confirmed to be helpful for stress adaptation. Copyright © 2002 John Wiley & Sons, Ltd. |
|---|---|
| AbstractList | The number of studies devoted to the scientific evaluation of phytotherapy is rapidly increasing since Western patients seem more oriented towards so‐called ‘alternative medicine’. Bearing such arguments in mind we decided to address attention to Eleutherococcus senticosus, a root of the Ginseng family known for thousands of years in China as a remedy for psychological distress. Forty‐five paid, healthy volunteers (20 males, 25 females) were recruited. Entry criteria were: good health, age 18–30 years, student and a Symptoms Rating Test score <10. At screening evaluation subjects were randomized to receive orally either placebo (Pl group) or
Eleutherococcus senticosus
(Es group) for 30 days, in a double‐blind design. Subjects were submitted to a stressful cognitive task, the Stroop Colour–Word test (Stroop CW), both before and after treatment. Stroop CW increased heart rate (HR) and systolic BP in every subject. In females there was a greater response than in males in terms of both systolic and diastolic BP. For both genders, the HR response to Stroop CW was reduced by Es treatment while no changes were found after Pl. In females, systolic BP was also reduced in Es group while it remained unchanged in Pl group. This study demonstrated that treatment with
Eleutherococcus senticosus
is able to reduce cardiovascular responses to stress in healthy young volunteers, while placebo was ineffective.
Eleutherococcus senticosus
is confirmed to be helpful for stress adaptation. Copyright © 2002 John Wiley & Sons, Ltd. The number of studies devoted to the scientific evaluation of phytotherapy is rapidly increasing since Western patients seem more oriented towards so‐called ‘alternative medicine’. Bearing such arguments in mind we decided to address attention to Eleutherococcus senticosus, a root of the Ginseng family known for thousands of years in China as a remedy for psychological distress. Forty‐five paid, healthy volunteers (20 males, 25 females) were recruited. Entry criteria were: good health, age 18–30 years, student and a Symptoms Rating Test score <10. At screening evaluation subjects were randomized to receive orally either placebo (Pl group) or Eleutherococcus senticosus (Es group) for 30 days, in a double‐blind design. Subjects were submitted to a stressful cognitive task, the Stroop Colour–Word test (Stroop CW), both before and after treatment. Stroop CW increased heart rate (HR) and systolic BP in every subject. In females there was a greater response than in males in terms of both systolic and diastolic BP. For both genders, the HR response to Stroop CW was reduced by Es treatment while no changes were found after Pl. In females, systolic BP was also reduced in Es group while it remained unchanged in Pl group. This study demonstrated that treatment with Eleutherococcus senticosus is able to reduce cardiovascular responses to stress in healthy young volunteers, while placebo was ineffective. Eleutherococcus senticosus is confirmed to be helpful for stress adaptation. Copyright © 2002 John Wiley & Sons, Ltd. |
| Author | Tarabusi, M. Facchinetti, F. Neri, I. |
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| Cites_doi | 10.1159/000012406 10.1016/S0167-8760(97)00092-5 10.1097/00006842-199903000-00006 10.1111/j.1469-8986.1987.tb00264.x 10.1016/S0022-3999(98)00075-0 10.1080/00224540009600494 10.1016/S0015-0282(97)81916-4 10.1016/S0306-4530(00)00046-9 10.1037/h0054651 10.1097/00006842-199803000-00019 10.1300/J013v30n03_08 10.1001/jama.279.19.1548 10.1093/geronb/54B.6.P339 10.1142/S0192415X81000159 10.1177/070674378302800208 |
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| Keywords | Human Cardiovascular control Treatment efficiency Sex Emotion emotionality Personality Phytotherapy Stress |
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| References | Guerra G, Zaimovic A, Mascetti GG, Gardini S, Zambelli U, Timpano M, Raggi MA, Brambilla F. Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 2001; 26: 91-107. Guillemain J, Godeau RP, Hubert F, Tetau M. Un stimulant d'origine vegetale: le teinture mère d'éleuthérococcus. Cahier Biotherapie 1981; 72: 45-49. Fava GA, Kellner R, Perini GI, Fava M, Michelacci M, Munari F, Pasquali Evangelisti L, Grandi S, Bernardi M, Mastrogiacomo I. Italina validation of the Symptoms Rating Test (SRT) and Symptoms Questionnaire (SQ). Can. J. Psychiatry 1983; 28: 117-23. Tarabusi M, Matteo ML, Volpe A, Facchinetti F. Stress-response in male partners of women submitted to in vitro fertilization and embryo transfer. Psychother. Psychosom. 2000; 69: 275-279. Giusti E, Rossi M. Ginseng ed Eleuterococco. Farmacologia e studi clinici. Erboristeria Domani 1994; 171: 88-103. Kirschbaum C, Kudielka BM, Gaab J, Shommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives in the activity of the hypothalamus-pituitary-adrenal axis. Psychosom. Med. 1999; 61: 155-162. Litschauer B, Zauchner S, Huemer KH, Kafka-Lutzow A. Cardiovascular, endocrine, and receptors measures as related to sex and the menstrual cycle phase. Psychosom. Med. 1998; 60: 219-226. British Herbal Compendium, 1992; 1: 43. Facchinetti F, Matteo ML, Artini GP, Volpe A, Genazzani AR. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization-embryo transfer treatment. Fertil Steril 1997; 67: 309-314. Stoney CM, Davis MC, Matthews KA. Sex differences in physiological responses to stress and in coronary heart disease: A causal link? Psychophysiology 1987; 24: 127-1. Uchino BN, Uno D, Holt-Lunstad J, Flinders JB. Age-related differences in cardiovascular reactivity during acute psychological stress in men and women. J. Gerontol. Psychol. Sci. Soc. Sci. 1999; 54: 339-46. Fulder SJ. Ginseng and hypothalamic-pituitary control stress. Am. J. Chin. Med. 1981; 9: 112-118. Mullis RL, Chapman P. Age, gender, and self-esteem differences in adolescent coping styles. J. Soc. Psychol. 2000; 140: 539-41. Piferi RL, Laweler KA. Hostility and cardiovascular reactivity of women during interpersonal confrontation. Women Health 2000; 30: 111-29. Stroop JR. Studies of interference in serial verbal reactions. J. Exp. Psychol. 1935; 18: 643-62. Astin JA. Why patients use alternative medicine. Results of a national study. JAMA 1998; 279: 1548-1553. Fichera LV, Andreassi Jl. Stress and personality as factor in women's cardiovascular reactivity. Int. J. Psychophysiol. 1998; 28: 143-55. Earle TL, Linden W, Weinberg J. Differential effects of harassment on cardiovascular and salivary cortisol stress reactivity and recovery in women and men. J. Psychosom. Res. 1999; 46: 125-141. 1987; 24 1998; 28 2000; 69 1994; 171 2000; 30 1997; 67 1999; 46 1981; 9 2000; 140 1999; 54 2001; 26 1998; 279 1998; 60 1999; 61 1981; 72 1983; 28 1992; 1 1935; 18 Giusti E (e_1_2_1_11_2) 1994; 171 Kirschbaum C (e_1_2_1_13_2) 1999; 61 e_1_2_1_6_2 e_1_2_1_7_2 e_1_2_1_5_2 e_1_2_1_2_2 e_1_2_1_3_2 e_1_2_1_12_2 e_1_2_1_15_2 Guillemain J (e_1_2_1_4_2) 1981; 72 e_1_2_1_16_2 (e_1_2_1_10_2) 1992; 1 e_1_2_1_14_2 e_1_2_1_19_2 e_1_2_1_8_2 e_1_2_1_17_2 e_1_2_1_9_2 e_1_2_1_18_2 |
| References_xml | – reference: Piferi RL, Laweler KA. Hostility and cardiovascular reactivity of women during interpersonal confrontation. Women Health 2000; 30: 111-29. – reference: Astin JA. Why patients use alternative medicine. Results of a national study. JAMA 1998; 279: 1548-1553. – reference: Stroop JR. Studies of interference in serial verbal reactions. J. Exp. Psychol. 1935; 18: 643-62. – reference: British Herbal Compendium, 1992; 1: 43. – reference: Guerra G, Zaimovic A, Mascetti GG, Gardini S, Zambelli U, Timpano M, Raggi MA, Brambilla F. Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 2001; 26: 91-107. – reference: Litschauer B, Zauchner S, Huemer KH, Kafka-Lutzow A. Cardiovascular, endocrine, and receptors measures as related to sex and the menstrual cycle phase. Psychosom. Med. 1998; 60: 219-226. – reference: Kirschbaum C, Kudielka BM, Gaab J, Shommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives in the activity of the hypothalamus-pituitary-adrenal axis. Psychosom. Med. 1999; 61: 155-162. – reference: Fichera LV, Andreassi Jl. Stress and personality as factor in women's cardiovascular reactivity. Int. J. Psychophysiol. 1998; 28: 143-55. – reference: Tarabusi M, Matteo ML, Volpe A, Facchinetti F. Stress-response in male partners of women submitted to in vitro fertilization and embryo transfer. Psychother. Psychosom. 2000; 69: 275-279. – reference: Giusti E, Rossi M. Ginseng ed Eleuterococco. Farmacologia e studi clinici. Erboristeria Domani 1994; 171: 88-103. – reference: Stoney CM, Davis MC, Matthews KA. Sex differences in physiological responses to stress and in coronary heart disease: A causal link? Psychophysiology 1987; 24: 127-1. – reference: Fava GA, Kellner R, Perini GI, Fava M, Michelacci M, Munari F, Pasquali Evangelisti L, Grandi S, Bernardi M, Mastrogiacomo I. Italina validation of the Symptoms Rating Test (SRT) and Symptoms Questionnaire (SQ). Can. J. Psychiatry 1983; 28: 117-23. – reference: Mullis RL, Chapman P. Age, gender, and self-esteem differences in adolescent coping styles. J. Soc. Psychol. 2000; 140: 539-41. – reference: Uchino BN, Uno D, Holt-Lunstad J, Flinders JB. Age-related differences in cardiovascular reactivity during acute psychological stress in men and women. J. Gerontol. Psychol. Sci. Soc. Sci. 1999; 54: 339-46. – reference: Fulder SJ. Ginseng and hypothalamic-pituitary control stress. Am. J. Chin. Med. 1981; 9: 112-118. – reference: Earle TL, Linden W, Weinberg J. Differential effects of harassment on cardiovascular and salivary cortisol stress reactivity and recovery in women and men. J. Psychosom. Res. 1999; 46: 125-141. – reference: Guillemain J, Godeau RP, Hubert F, Tetau M. Un stimulant d'origine vegetale: le teinture mère d'éleuthérococcus. Cahier Biotherapie 1981; 72: 45-49. – reference: Facchinetti F, Matteo ML, Artini GP, Volpe A, Genazzani AR. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization-embryo transfer treatment. Fertil Steril 1997; 67: 309-314. – volume: 61 start-page: 155 year: 1999 end-page: 162 article-title: Impact of gender, menstrual cycle phase, and oral contraceptives in the activity of the hypothalamus–pituitary–adrenal axis publication-title: Psychosom. Med. – volume: 30 start-page: 111 year: 2000 end-page: 29 article-title: Hostility and cardiovascular reactivity of women during interpersonal confrontation publication-title: Women Health – volume: 28 start-page: 143 year: 1998 end-page: 55 article-title: Stress and personality as factor in women's cardiovascular reactivity publication-title: Int. J. Psychophysiol. – volume: 69 start-page: 275 year: 2000 end-page: 279 article-title: Stress‐response in male partners of women submitted to fertilization and embryo transfer publication-title: Psychother. Psychosom. – volume: 279 start-page: 1548 year: 1998 end-page: 1553 article-title: Why patients use alternative medicine. Results of a national study publication-title: JAMA – volume: 28 start-page: 117 year: 1983 end-page: 23 article-title: Italina validation of the Symptoms Rating Test (SRT) and Symptoms Questionnaire (SQ) publication-title: Can. J. Psychiatry – volume: 140 start-page: 539 year: 2000 end-page: 41 article-title: Age, gender, and self‐esteem differences in adolescent coping styles publication-title: J. Soc. Psychol. – volume: 72 start-page: 45 year: 1981 end-page: 49 article-title: Un stimulant d'origine vegetale: le teinture mère d'éleuthérococcus publication-title: Cahier Biotherapie – volume: 67 start-page: 309 year: 1997 end-page: 314 article-title: An increased vulnerability to stress is associated with a poor outcome of fertilization–embryo transfer treatment publication-title: Fertil Steril – volume: 1 start-page: 43 year: 1992 publication-title: British Herbal Compendium – volume: 9 start-page: 112 year: 1981 end-page: 118 article-title: Ginseng and hypothalamic–pituitary control stress publication-title: Am. J. Chin. Med. – volume: 171 start-page: 88 year: 1994 end-page: 103 article-title: Ginseng ed Eleuterococco. Farmacologia e studi clinici publication-title: Erboristeria Domani – volume: 26 start-page: 91 year: 2001 end-page: 107 article-title: Neuroendocrine responses to experimentally‐induced psychological stress in healthy humans publication-title: Psychoneuroendocrinology – volume: 18 start-page: 643 year: 1935 end-page: 62 article-title: Studies of interference in serial verbal reactions publication-title: J. Exp. Psychol. – volume: 60 start-page: 219 year: 1998 end-page: 226 article-title: Cardiovascular, endocrine, and receptors measures as related to sex and the menstrual cycle phase publication-title: Psychosom. Med. – volume: 24 start-page: 127 year: 1987 end-page: 1 article-title: Sex differences in physiological responses to stress and in coronary heart disease: A causal link? publication-title: Psychophysiology – volume: 46 start-page: 125 year: 1999 end-page: 141 article-title: Differential effects of harassment on cardiovascular and salivary cortisol stress reactivity and recovery in women and men publication-title: J. Psychosom. Res. – volume: 54 start-page: 339 year: 1999 end-page: 46 article-title: Age‐related differences in cardiovascular reactivity during acute psychological stress in men and women publication-title: J. Gerontol. Psychol. Sci. Soc. Sci. – ident: e_1_2_1_8_2 doi: 10.1159/000012406 – ident: e_1_2_1_17_2 doi: 10.1016/S0167-8760(97)00092-5 – volume: 61 start-page: 155 year: 1999 ident: e_1_2_1_13_2 article-title: Impact of gender, menstrual cycle phase, and oral contraceptives in the activity of the hypothalamus–pituitary–adrenal axis publication-title: Psychosom. Med. doi: 10.1097/00006842-199903000-00006 – ident: e_1_2_1_14_2 doi: 10.1111/j.1469-8986.1987.tb00264.x – ident: e_1_2_1_15_2 doi: 10.1016/S0022-3999(98)00075-0 – volume: 72 start-page: 45 year: 1981 ident: e_1_2_1_4_2 article-title: Un stimulant d'origine vegetale: le teinture mère d'éleuthérococcus publication-title: Cahier Biotherapie – ident: e_1_2_1_18_2 doi: 10.1080/00224540009600494 – ident: e_1_2_1_7_2 doi: 10.1016/S0015-0282(97)81916-4 – ident: e_1_2_1_9_2 doi: 10.1016/S0306-4530(00)00046-9 – ident: e_1_2_1_6_2 doi: 10.1037/h0054651 – volume: 171 start-page: 88 year: 1994 ident: e_1_2_1_11_2 article-title: Ginseng ed Eleuterococco. Farmacologia e studi clinici publication-title: Erboristeria Domani – ident: e_1_2_1_12_2 doi: 10.1097/00006842-199803000-00019 – ident: e_1_2_1_19_2 doi: 10.1300/J013v30n03_08 – ident: e_1_2_1_2_2 doi: 10.1001/jama.279.19.1548 – ident: e_1_2_1_16_2 doi: 10.1093/geronb/54B.6.P339 – ident: e_1_2_1_3_2 doi: 10.1142/S0192415X81000159 – ident: e_1_2_1_5_2 doi: 10.1177/070674378302800208 – volume: 1 start-page: 43 year: 1992 ident: e_1_2_1_10_2 publication-title: British Herbal Compendium |
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