Chondrocytes from osteoarthritic cartilage of obese patients show altered adiponectin receptors expression and response to adiponectin

• Published in: Journal of orthopaedic research Vol. 39; no. 11; pp. 2333 - 2339
• Main Authors: Harasymowicz, Natalia Sara, Azfer, Asim, Burnett, Richard, Simpson, Hamish, Salter, Donald M.
• Format: Journal Article
• Language: English
• Published: United States 01.11.2021
• Subjects: adipokines; Adiponectin; arthritis; BMI; cartilage; Cartilage - metabolism; Cartilage, Articular - pathology; Chondrocytes - metabolism; Diabetes Mellitus, Type 2; Female; Humans; Interleukin-6 - metabolism; Male; Matrix Metalloproteinase 1 - metabolism; Matrix Metalloproteinase 2 - metabolism; obesity; Obesity - metabolism; Osteoarthritis - metabolism; Receptors, Adiponectin - genetics; Receptors, Adiponectin - metabolism; Vascular Cell Adhesion Molecule-1 - metabolism; Vascular Cell Adhesion Molecule-1 - pharmacology; adiponectin; OA; arthritis; cartilage; adipokines; obesity; BMI

Obesity and osteoarthritis (OA) are well‐known comorbidities and their precise molecular interactions are still unidentified. Adiponectin, a major adipokine, known to have an anti‐inflammatory effect in atherosclerosis or Type 2 Diabetes Mellitus (T2DM), has also been postulated to be pro‐inflammato...