Using mouse models to investigate the pathophysiology, treatment, and prevention of post‐traumatic osteoarthritis

• Published in: Journal of orthopaedic research Vol. 35; no. 3; pp. 424 - 439
• Main Authors: Blaker, Carina L., Clarke, Elizabeth C., Little, Christopher B.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2017
• Subjects: Animals; disease model; Disease Models, Animal; Joints - injuries; Mice; mouse; Osteoarthritis - etiology; post‐traumatic osteoarthritis; Wounds and Injuries - complications; post-traumatic osteoarthritis; mouse; disease model

ABSTRACT Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of progression, and degree of associated disability in any individual, remain incompletely understood. What constitutes an “OA‐inducing injury”...