Using mouse models to investigate the pathophysiology, treatment, and prevention of post‐traumatic osteoarthritis

ABSTRACT Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of progression, and degree of associated disability in any individual, remain incompletely understood. What constitutes an “OA‐inducing injury”...

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Published inJournal of orthopaedic research Vol. 35; no. 3; pp. 424 - 439
Main Authors Blaker, Carina L., Clarke, Elizabeth C., Little, Christopher B.
Format Journal Article
LanguageEnglish
Published United States 01.03.2017
Subjects
Animals
disease model
Disease Models, Animal
Joints - injuries
Mice
mouse
Osteoarthritis - etiology
post‐traumatic osteoarthritis
Wounds and Injuries - complications
post-traumatic osteoarthritis
mouse
disease model
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Abstract ABSTRACT Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of progression, and degree of associated disability in any individual, remain incompletely understood. What constitutes an “OA‐inducing injury” is not defined. In line with advances in the traumatic brain injury field, we propose the scope of PTOA‐inducing injuries be expanded to include not only those causing immediate structural damage and instability (Type I), but also those without initial instability/damage from moderate (Type II) or minor (Type III) loading severity. A review of the literature revealed this full spectrum of potential PTOA subtypes can be modeled in mice, with 27 Type I, 6 Type II, and 4 Type III models identified. Despite limitations due to cartilage anatomy, joint size, and bio‐fluid availability, mice offer advantages as preclinical models to study PTOA, particularly genetically modified strains. Histopathology was the most common disease outcome, cartilage more frequently studied than bone or synovium, and meniscus and ligaments rarely evaluated. Other methods used to examine PTOA included gene expression, protein analysis, and imaging. Despite the major issues reported by patients being pain and biomechanical dysfunction, these were the least commonly measured outcomes in mouse models. Informative correlations of simultaneously measured disease outcomes in individual animals, was rarely done in any mouse PTOA model. This review has identified knowledge gaps that need to be addressed to increase understanding and improve prevention and management of PTOA. Preclinical mouse models play a critical role in these endeavors. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:424–439, 2017.
AbstractList Post-traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of progression, and degree of associated disability in any individual, remain incompletely understood. What constitutes an "OA-inducing injury" is not defined. In line with advances in the traumatic brain injury field, we propose the scope of PTOA-inducing injuries be expanded to include not only those causing immediate structural damage and instability (Type I), but also those without initial instability/damage from moderate (Type II) or minor (Type III) loading severity. A review of the literature revealed this full spectrum of potential PTOA subtypes can be modeled in mice, with 27 Type I, 6 Type II, and 4 Type III models identified. Despite limitations due to cartilage anatomy, joint size, and bio-fluid availability, mice offer advantages as preclinical models to study PTOA, particularly genetically modified strains. Histopathology was the most common disease outcome, cartilage more frequently studied than bone or synovium, and meniscus and ligaments rarely evaluated. Other methods used to examine PTOA included gene expression, protein analysis, and imaging. Despite the major issues reported by patients being pain and biomechanical dysfunction, these were the least commonly measured outcomes in mouse models. Informative correlations of simultaneously measured disease outcomes in individual animals, was rarely done in any mouse PTOA model. This review has identified knowledge gaps that need to be addressed to increase understanding and improve prevention and management of PTOA. Preclinical mouse models play a critical role in these endeavors. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:424-439, 2017.
ABSTRACT Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of progression, and degree of associated disability in any individual, remain incompletely understood. What constitutes an “OA‐inducing injury” is not defined. In line with advances in the traumatic brain injury field, we propose the scope of PTOA‐inducing injuries be expanded to include not only those causing immediate structural damage and instability (Type I), but also those without initial instability/damage from moderate (Type II) or minor (Type III) loading severity. A review of the literature revealed this full spectrum of potential PTOA subtypes can be modeled in mice, with 27 Type I, 6 Type II, and 4 Type III models identified. Despite limitations due to cartilage anatomy, joint size, and bio‐fluid availability, mice offer advantages as preclinical models to study PTOA, particularly genetically modified strains. Histopathology was the most common disease outcome, cartilage more frequently studied than bone or synovium, and meniscus and ligaments rarely evaluated. Other methods used to examine PTOA included gene expression, protein analysis, and imaging. Despite the major issues reported by patients being pain and biomechanical dysfunction, these were the least commonly measured outcomes in mouse models. Informative correlations of simultaneously measured disease outcomes in individual animals, was rarely done in any mouse PTOA model. This review has identified knowledge gaps that need to be addressed to increase understanding and improve prevention and management of PTOA. Preclinical mouse models play a critical role in these endeavors. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:424–439, 2017.
Author Clarke, Elizabeth C.
Blaker, Carina L.
Little, Christopher B.
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Fri Dec 06 00:51:54 EST 2024
Sat Sep 28 08:48:19 EDT 2024
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Issue 3
Keywords post-traumatic osteoarthritis
mouse
disease model
Language English
License 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
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PublicationCentury 2000
PublicationDate March 2017
2017-03-00
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  year: 2017
  text: March 2017
PublicationDecade 2010
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PublicationTitle Journal of orthopaedic research
PublicationTitleAlternate J Orthop Res
PublicationYear 2017
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SecondaryResourceType review_article
Snippet ABSTRACT Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of...
Post-traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors contributing to the risk of PTOA occurring, the rate of...
SourceID proquest
crossref
pubmed
wiley
SourceType Aggregation Database
Index Database
Publisher
StartPage 424
SubjectTerms Animals
disease model
Disease Models, Animal
Joints - injuries
Mice
mouse
Osteoarthritis - etiology
post‐traumatic osteoarthritis
Wounds and Injuries - complications
Title Using mouse models to investigate the pathophysiology, treatment, and prevention of post‐traumatic osteoarthritis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjor.23343
https://www.ncbi.nlm.nih.gov/pubmed/27312470
https://search.proquest.com/docview/1826699304
Volume 35
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