Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)
Introduction The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden. Methods We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test score...
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Published in | Alzheimer's & dementia Vol. 17; no. 12; pp. 1966 - 1975 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2021
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Subjects | |
Online Access | Get full text |
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Abstract | Introduction
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.
Methods
We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.
Results
The 2020 US Census–adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7–11.9): 10.0% among non‐Hispanic Whites, 14.0% among Hispanics, and 18.6% among non‐Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75–6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98–14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.
Discussion
The number of people with clinical AD will increase as the “baby boom” generation reaches older ages, exerting a strong upward influence on disease burden. |
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AbstractList | Introduction
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.
Methods
We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.
Results
The 2020 US Census–adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7–11.9): 10.0% among non‐Hispanic Whites, 14.0% among Hispanics, and 18.6% among non‐Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75–6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98–14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.
Discussion
The number of people with clinical AD will increase as the “baby boom” generation reaches older ages, exerting a strong upward influence on disease burden. The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.INTRODUCTIONThe estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.METHODSWe estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores.The 2020 US Census-adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7-11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75-6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98-14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.RESULTSThe 2020 US Census-adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7-11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75-6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98-14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men.The number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden.DISCUSSIONThe number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden. The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden. We estimated people with cognitive impairment using a quasibinomial regression model in 10,342 participants with cognitive test scores. The 2020 US Census-adjusted prevalence of clinical AD was 11.3% (95% confidence interval [CI] = 10.7-11.9): 10.0% among non-Hispanic Whites, 14.0% among Hispanics, and 18.6% among non-Hispanic Blacks. We estimate that in 2020, 6.07 (95% CI = 5.75-6.38) million people were living with clinical AD, which increases to 13.85 (95% CI = 12.98-14.74) million in 2060, 423% higher among Hispanics, 192% higher among Blacks, and 63% higher among Whites. However, there are predicted to be more significant increases in later years among those over 85 and women compared to men. The number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden. |
Author | Weuve, Jennifer Barnes, Lisa L. McAninch, Elizabeth A. Rajan, Kumar B. Wilson, Robert S. Evans, Denis A. |
Author_xml | – sequence: 1 givenname: Kumar B. surname: Rajan fullname: Rajan, Kumar B. email: Kumar_Rajan@Rush.edu organization: Rush University Medical Center – sequence: 2 givenname: Jennifer surname: Weuve fullname: Weuve, Jennifer organization: Boston University School of Public Health – sequence: 3 givenname: Lisa L. surname: Barnes fullname: Barnes, Lisa L. organization: Rush University Medical Center – sequence: 4 givenname: Elizabeth A. surname: McAninch fullname: McAninch, Elizabeth A. organization: Rush University Medical Center – sequence: 5 givenname: Robert S. surname: Wilson fullname: Wilson, Robert S. organization: Rush University Medical Center – sequence: 6 givenname: Denis A. surname: Evans fullname: Evans, Denis A. organization: Rush University Medical Center |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34043283$$D View this record in MEDLINE/PubMed |
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Snippet | Introduction
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.... The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden. We estimated... The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden.INTRODUCTIONThe... |
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SubjectTerms | 2020 US prevalence Aged Aged, 80 and over Alzheimer Disease - epidemiology clinical Alzheimer's disease Cognitive Dysfunction - epidemiology Cost of Illness Ethnicity - statistics & numerical data Female forecasting Humans Male mild cognitive impairment Models, Statistical Prevalence |
Title | Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060) |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.12362 https://www.ncbi.nlm.nih.gov/pubmed/34043283 https://www.proquest.com/docview/2533314411 |
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