Rhomboid proteases in invasion and replication of Apicomplexa
Summary In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions abo...
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Published in | Molecular microbiology Vol. 97; no. 2; pp. 185 - 188 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
01.07.2015
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Abstract | Summary
In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rhomboids in Toxoplasma, while also strongly arguing against other recently proposed roles for these proteases. |
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AbstractList | Summary
In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rhomboids in Toxoplasma, while also strongly arguing against other recently proposed roles for these proteases. In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rhomboids in Toxoplasma, while also strongly arguing against other recently proposed roles for these proteases. In this issue of M olecular M icrobiology , Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite T oxoplasma gondii . This study, together with several other recent publications, raises new questions about the function of these rhomboids in T oxoplasma , while also strongly arguing against other recently proposed roles for these proteases. |
Author | Stewart, Rebecca J. Tonkin, Christopher J. |
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Cites_doi | 10.1038/ncomms3552 10.1074/jbc.275.19.14346 10.1093/emboj/21.7.1577 10.1371/journal.ppat.0020113 10.1111/mmi.13021 10.1073/pnas.1114661109 10.1083/jcb.201206112 10.1371/journal.pone.0100450 10.1016/S0020-7519(00)00124-7 10.1128/mBio.01795-14 10.1038/nmeth.2301 10.1016/j.ijpara.2005.04.001 10.1073/pnas.0407918102 10.1126/science.1199284 10.1111/j.1365-2958.2005.04772.x 10.1038/ncomms5098 10.1371/journal.ppat.1003943 10.1371/journal.ppat.1000858 10.1186/gb-2011-12-10-231 10.1016/j.bbamem.2013.04.017 10.1016/S0092-8674(01)00525-6 |
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References_xml | – volume: 35 start-page: 747 year: 2005 end-page: 756 article-title: Apicomplexan rhomboids have a potential role in microneme protein cleavage during host cell invasion publication-title: Int J Parasitol – volume: 97 start-page: 244 year: 2015 end-page: 262 article-title: Distinct contribution of rhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion publication-title: Mol Microbiol – volume: 1828 start-page: 2908 year: 2013 end-page: 2915 article-title: The roles of intramembrane proteases in protozoan parasites publication-title: Biochim Biophys Acta – start-page: 1 year: 2014 end-page: 242 – volume: 10 start-page: 125 year: 2012 end-page: 127 article-title: Conditional genome engineering in uncovers alternative invasion mechanisms publication-title: Nat Methods – volume: 4 start-page: 2552 year: 2013 article-title: Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion publication-title: Nat Commun – volume: 57 start-page: 1342 year: 2005 end-page: 1356 article-title: Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens publication-title: Mol Microbiol – volume: 10 start-page: e1003943 year: 2014 article-title: erythrocyte invasion: combining function with immune evasion publication-title: PLoS Pathog – volume: 331 start-page: 473 year: 2011 end-page: 477 article-title: Intramembrane cleavage of AMA1 triggers to switch from an invasive to a replicative mode publication-title: Science – volume: 9 start-page: e100450 year: 2014 article-title: Efficient genome engineering of using CRISPR/Cas9 publication-title: PLoS ONE – volume: 2 start-page: e113 year: 2006 article-title: Two rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria publication-title: PLoS Pathog – volume: 102 start-page: 4146 year: 2005 end-page: 4151 article-title: A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by publication-title: Proc Natl Acad Sci USA – volume: 275 start-page: 14346 year: 2000 end-page: 14353 article-title: The adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite‐derived proteases publication-title: J Biol Chem – volume: 198 start-page: 961 year: 2012 end-page: 971 article-title: The cell biology of disease: the cellular and molecular basis for malaria parasite invasion of the human red blood cell publication-title: J Cell Biol – volume: 109 start-page: 7463 year: 2012 end-page: 7468 article-title: Intramembrane proteolysis of apical membrane antigen 1 facilitates host‐cell invasion but is dispensable for replication publication-title: Proc Natl Acad Sci USA – volume: 21 start-page: 1577 year: 2002 end-page: 1585 article-title: Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite publication-title: EMBO J – volume: 30 start-page: 1217 year: 2000 end-page: 1258 article-title: : from animals to humans publication-title: Int J Parasitol – volume: 12 start-page: 231 year: 2011 article-title: The rhomboid protease family: a decade of progress on function and mechanism publication-title: Genome Biol – volume: 5 start-page: e01795‐14 year: 2014 article-title: Efficient gene disruption in diverse strains of using CRISPR/CAS9 publication-title: MBio – volume: 5 start-page: 4098 year: 2014 article-title: Plasticity and redundancy among AMA–RON pairs ensure host cell entry of parasites publication-title: Nat Commun – volume: 6 start-page: e1000858 year: 2010 article-title: Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by publication-title: PLoS Pathog – volume: 107 start-page: 173 year: 2001 end-page: 182 article-title: Drosophila rhomboid‐1 defines a family of putative intramembrane serine proteases publication-title: Cell – ident: e_1_2_6_4_1 doi: 10.1038/ncomms3552 – ident: e_1_2_6_7_1 doi: 10.1074/jbc.275.19.14346 – ident: e_1_2_6_12_1 doi: 10.1093/emboj/21.7.1577 – ident: e_1_2_6_3_1 doi: 10.1371/journal.ppat.0020113 – ident: e_1_2_6_14_1 doi: 10.1111/mmi.13021 – ident: e_1_2_6_13_1 doi: 10.1073/pnas.1114661109 – ident: e_1_2_6_8_1 doi: 10.1083/jcb.201206112 – ident: e_1_2_6_18_1 doi: 10.1371/journal.pone.0100450 – ident: e_1_2_6_19_1 doi: 10.1016/S0020-7519(00)00124-7 – ident: e_1_2_6_16_1 doi: 10.1128/mBio.01795-14 – ident: e_1_2_6_2_1 doi: 10.1038/nmeth.2301 – ident: e_1_2_6_9_1 doi: 10.1016/j.ijpara.2005.04.001 – ident: e_1_2_6_22_1 – ident: e_1_2_6_5_1 doi: 10.1073/pnas.0407918102 – ident: e_1_2_6_15_1 doi: 10.1126/science.1199284 – ident: e_1_2_6_10_1 doi: 10.1111/j.1365-2958.2005.04772.x – ident: e_1_2_6_11_1 doi: 10.1038/ncomms5098 – ident: e_1_2_6_23_1 doi: 10.1371/journal.ppat.1003943 – ident: e_1_2_6_6_1 doi: 10.1371/journal.ppat.1000858 – ident: e_1_2_6_20_1 doi: 10.1186/gb-2011-12-10-231 – ident: e_1_2_6_17_1 doi: 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In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during... In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion... In this issue of M olecular M icrobiology , Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during... |
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SubjectTerms | Cell Adhesion Molecules - metabolism Humans Peptide Hydrolases - metabolism Protozoan Proteins - metabolism Toxoplasma - enzymology Toxoplasma - pathogenicity |
Title | Rhomboid proteases in invasion and replication of Apicomplexa |
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