K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin

• Published in: Diabetes (New York, N.Y.) Vol. 49; no. 7; pp. 1131 - 1136
• Main Authors: Kullin, M, Li, Z, Hansen, J B, Björk, E, Sandler, S, Karlsson, F A
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.07.2000
• Subjects: Animals; Cells, Cultured; Diazoxide - analogs & derivatives; Diazoxide - pharmacology; Glucose - metabolism; Glycolysis - drug effects; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - cytology; Islets of Langerhans - drug effects; Islets of Langerhans - physiology; Kinetics; Poly(ADP-ribose) Polymerases - metabolism; Potassium Channels - agonists; Potassium Channels - physiology; Proinsulin - biosynthesis; Rats; Rats, Sprague-Dawley; Streptozocin - antagonists & inhibitors; Streptozocin - toxicity

K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin. M Kullin , Z Li , J B Hansen , E Björk , S Sandler and F A Karlsson Department of Medical Sciences, Uppsala University, Sweden. Abstract We examined the influence of two K(ATP) channel openers, diazoxide and an ana...