Impact of target‐mediated drug disposition on hetrombopag pharmacokinetics and pharmacodynamics in Chinese healthy subjects and patients with chronic idiopathic thrombocytopenic purpura - Wang, Zhenlei; Zeng, Zhijun; Ye, Lijun; Zhu, Xiaohong; Pei, Yuwen; Wang, Yongsheng; Zheng, Li (British journal of clinical pharmacology, 2022)
Keywords: China; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Healthy Volunteers; hetrombopag; Humans; Hydrazones; idiopathic thrombocytopenic purpura; Models, Biological; platelet countspopulation pharmacokinetic/pharmacodynamictarget‐mediated drug disposition; Purpura, Thrombocytopenic, Idiopathic - drug therapy; Pyrazolones - pharmacokinetics; China; platelet countspopulation pharmacokinetic/pharmacodynamictarget-mediated drug disposition; idiopathic thrombocytopenic purpura; hetrombopag