Development of AITC‐induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin

• Published in: British journal of clinical pharmacology Vol. 87; no. 1; pp. 129 - 139
• Main Authors: Joseph, Victory, Yang, Xiaoying, Gao, Simon S., Elstrott, Justin, Weimer, Robby M., Theess, Wiebke, Thrasher, Cory, Singh, Nand, Lin, Joseph, Bauer, Rebecca N.
• Format: Journal Article
• Language: English
• Published: England 01.01.2021
• Subjects: allyl isothiocyanate; biomarker; laser speckle contrast imaging; neurogenic inflammation; pharmacodynamic; TRPA1; laser speckle contrast imaging; pharmacodynamic; TRPA1; biomarker; allyl isothiocyanate; neurogenic inflammation

Background and Purpose Develop a translational assay of Transient Receptor Potential Ankyrin 1 (TRPA1) activity for use as a preclinical and clinical biomarker. Experimental Approach Allyl isothiocyanate (AITC), capsaicin or citric acid were applied to ears of wildtype and Trpa1‐knock out (Trpa1 KO)...