Exosomal microRNAs from PBMCs stimulated with culprit drugs enhanced keratinocyte cell death in Stevens–Johnson syndrome/toxic epidermal necrolysis

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 37; no. 7; pp. 1375 - 1384
• Main Authors: Suthumchai, Nithikan, Buranapraditkun, Supranee, Thantiworasit, Pattarawat, Rerknimitr, Pawinee, Wongpiyabovorn, Jongkonnee, Khanaraksombat, Suparada, Reantragoon, Rangsima, Klaewsongkram, Jettanong
• Format: Journal Article
• Language: English
• Published: England 01.07.2023
• Subjects: Cell Death; Eosinophilia; Humans; Keratinocytes - metabolism; Leukocytes, Mononuclear - metabolism; MicroRNAs - metabolism; Stevens-Johnson Syndrome - therapy

Background Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reactions with eosinophilia and systemic symptoms (DRESS) are both severe cutaneous adverse reactions. Keratinocyte death is much more prominent in SJS/TEN compared to DRESS. Objective This study aimed to investigate t...