From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase

• Published in: Angewandte Chemie Vol. 128; no. 40; pp. 12436 - 12439
• Main Authors: Olmedo, Andrés, Aranda, Carmen, del Río, José C., Kiebist, Jan, Scheibner, Katrin, Martínez, Angel T., Gutiérrez, Ana
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 26.09.2016; Wiley Subscription Services, Inc
• Subjects: Acids; Alkane; Alkanes; Carbonsäuren; Carboxylic acids; Cascade chemical reactions; Cascades; Chains; Chemical reactions; Chemistry; Conversion; Dodecane; Dodecanol; Enzymes; Fungi; Heme; Hydrogen peroxide; Hydroxylation; Lauric acid; Organic chemistry; Oxidation; Oxidoreduktasen; Oxygenation; Peroxidase; Peroxygenase; Terminale Hydroxylierung; Terminals; Tetradecane

A new heme–thiolate peroxidase catalyzes the hydroxylation of n‐alkanes at the terminal position—a challenging reaction in organic chemistry—with H2O2 as the only cosubstrate. Besides the primary product, 1‐dodecanol, the conversion of dodecane yielded dodecanoic, 12‐hydroxydodecanoic, and 1,12‐dode...