Comparing proteins by their internal dynamics: Exploring structure–function relationships beyond static structural alignments

• Published in: Physics of life reviews Vol. 10; no. 1; pp. 1 - 26
• Main Author: Micheletti, Cristian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2013
• Subjects: Animals; Databases, Protein; Humans; Molecular Dynamics Simulation; PDZ Domains; Peptide Hydrolases - chemistry; Peptide Hydrolases - metabolism; Proteins - chemistry; Proteins - metabolism; Structural Homology, Protein; Structure-Activity Relationship

The growing interest for comparing protein internal dynamics owes much to the realisation that protein function can be accompanied or assisted by structural fluctuations and conformational changes. Analogously to the case of functional structural elements, those aspects of protein flexibility and dy...