HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A02:01 transgenic mice against ocular herpes

• Published in: The Journal of immunology (1950) Vol. 194; no. 5; pp. 2232 - 2248
• Main Authors: Srivastava, Ruchi, Khan, Arif A, Spencer, Doran, Vahed, Hawa, Lopes, Patricia P, Thai, Nhi Thi Uyen, Wang, Christine, Pham, Thanh T, Huang, Jiawei, Scarfone, Vanessa M, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Adolescent; Adult; Aged; Algorithms; Amino Acid Sequence; Animals; Antigens, Viral - chemistry; Antigens, Viral - immunology; Asymptomatic Diseases; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; CD8-Positive T-Lymphocytes - virology; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Female; Herpes simplex virus; Herpesvirus 1, Human - chemistry; Herpesvirus 1, Human - immunology; Herpesvirus 2, Human - chemistry; Herpesvirus 2, Human - immunology; HLA-A2 Antigen - chemistry; HLA-A2 Antigen - immunology; Humans; Immunity, Cellular; Immunization; Immunologic Memory; Keratitis, Herpetic - immunology; Keratitis, Herpetic - pathology; Keratitis, Herpetic - prevention & control; Keratitis, Herpetic - virology; Male; Mice; Mice, Transgenic; Middle Aged; Molecular Sequence Data; Peptides - administration & dosage; Peptides - chemistry; Peptides - immunology; Viral Proteins - chemistry; Viral Proteins - immunology

The HSV type 1 tegument virion phosphoprotein (VP) 11/12 (VP11/12) is a major Ag targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether and which VP11/12 epitope-specific CD8(+) T cells play a role in the "natural" protection seen in seropositive healthy asymptomati...