Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

• Published in: Biochimica et biophysica acta. Reviews on cancer Vol. 1879; no. 4; p. 189121
• Main Authors: Zhang, Zheng, Lv, Zhen Gang, Lu, Miao, Li, Haifeng, Zhou, Jiahua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2024
• Subjects: Animals; Cancer Pain - metabolism; Cancer Pain - pathology; Carcinogenesis - pathology; Crosstalk; Disease Progression; Humans; Neoplasm Invasiveness; Neoplasms - pathology; Nerve; Tumor; Tumor Microenvironment; Crosstalk; SACC; 6-OHDA; PNI; ADM; Nerve; TDO2; Tumor; NK1R; SCs; HCC; IPMN; Ems; NGF; CSF-1; EMT; MMP; MAG; PDAC; CAP; AAV; CGRP; COX-2; ANS; ADRB2; 12/15-LOX; IMs; CSC; iCAFs; DCs; NCAM1; GC; PGE2; Tumor microenvironment; NSCLC; BDNF; Tregs; VEGF; Ach; TRPV1; TME; OTSCC; MDSCs; PIN; PSCs; PanIN; NMU; DRG; ZFP277; CHRM

The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition,...