Giving a good start to a new life via maternal brain allostatic adaptations in pregnancy

• Published in: Frontiers in neuroendocrinology Vol. 53; p. 100739
• Main Authors: Russell, John A., Brunton, Paula J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019
• Subjects: Adaptation, Physiological - physiology; Allopregnanolone; Allostasis; Animals; Brain - growth & development; Epigenetics; Female; Fetal Development - physiology; Fetal programming; Humans; Hypothalamo-Hypophyseal System - metabolism; Hypothalamo-pituitary-adrenal axis; Neuropeptides; Neurosecretory Systems - metabolism; Obesity; Opioids; Oxytocin; Pituitary-Adrenal System - metabolism; Pregnancy; Social stress; Obesity; Oxytocin; Hypothalamo-pituitary-adrenal axis; Opioids; Epigenetics; Neuropeptides; Social stress; Fetal programming; Allopregnanolone; Allostasis

•Maternal neuroendocrine allostatic adaptations promote a successful pregnancy.•Maternal obesity causes pregnancy problems and programs obesity in the offspring.•Molecular allostatic mechanisms reduce stress responses in pregnancy.•Maternal social stress programs anxiety and stress responses in the...