Roles of miRNAs in regulating ovarian cancer stemness

• Published in: Biochimica et biophysica acta. Reviews on cancer Vol. 1879; no. 6; p. 189191
• Main Author: Chong, Zhi-Xiong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; CSC; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs - genetics; miRNAs; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Prognostic biomarkers; Signal Transduction; Therapeutic agents; NRP2; ZEB1/2; CDC; MDSC; JNK; WWC1; PTEN; CDK; TAZ; AREG; ERBB; SLUG; Ovarian cancer; MYLK; FOXQ1; MAML; OCT4; TMEM100; DNMT; UTR; PI3K; ALDH1; CtBP2; LATS; mTOR; GPR137; AML; NOD; CML; FGF; MST1; PTPN; BCL; ARID1A; ADAR2; DKK1; EMT; DDB2; IκBα; ADAM19; MEK; NA; SCNN1D; TBL1XR1; PIP3; PTPLAD2; DOCK1; PIP2; ABCG2; ERK; GAS7; HDAC; Prognostic biomarkers; lncRNA; miRNAs; LRP5; RTK; SAV; XIAP; YAP; LKB1; SCID; EGFR; SOCS3; CSC; miRNA; CSL; WAF1; SNAIL; CD; EGR1; NF-kß; HIF; CMTM4; GSK-3ß; VEGF; MYPT1; STAT3; IKK; HMGA2; RAB27A; AKT; KLF4; S100B; Therapeutic agents; DLG2; PAR2; MOB1; SP1; SFRP; NICD; BAX; NANOG; HOXD9; SOX

Ovarian cancer is one of the gynaecology malignancies with the highest mortality rate. Ovarian cancer stem cell (CSC) is a subpopulation of ovarian cancer cells with increased self-renewability, aggression, metastatic potentials, and resistance to conventional anti-cancer therapy. The emergence of o...