Organizational effects of testosterone on learning strategy preference and muscarinic receptor binding in prepubertal rats

• Published in: Hormones and behavior Vol. 110; pp. 1 - 9
• Main Authors: Grissom, Elin M., Hawley, Wayne R., Dohanich, Gary P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019
• Subjects: Animals; Animals, Newborn; Corpus Striatum - drug effects; Female; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Male; Maze Learning - drug effects; Muscarinic; Neostriatum - drug effects; Neostriatum - metabolism; Organizational; Place strategy; Protein Binding; Rats; Rats, Long-Evans; Receptors, Muscarinic - metabolism; Sex Characteristics; Sex differences; Sexual Maturation - drug effects; Sexual Maturation - physiology; Stimulus-response strategy; Testosterone; Testosterone - pharmacology; Place strategy; Testosterone; Muscarinic; Stimulus-response strategy; Sex differences; Organizational; Hippocampus

Prior to puberty, male rats, but not female rats, prefer a striatum-based stimulus-response learning strategy rather than a hippocampus-based place strategy on a water maze task that can be solved using either strategy. Neurochemically, learning strategy preference has been linked to the ratio of ch...