Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 127; p. 110805
• Main Authors: Pearl-Dowler, Leora, Posa, Luca, Lopez-Canul, Martha, Teggin, Alexandra, Gobbi, Gabriella
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 20.12.2023
• Subjects: Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - pharmacology; Animals; Antinociceptive descending pathway; Cannabinoid Receptor Agonists - administration & dosage; Cannabinoid Receptor Agonists - pharmacology; Cannabis; Dose-Response Relationship, Drug; Dronabinol - administration & dosage; Dronabinol - pharmacology; Drug Tolerance; Injections, Intraperitoneal; Male; Medulla Oblongata - drug effects; Morphine - administration & dosage; Morphine - pharmacology; Morphine tolerance; Neuropathic pain; Periaqueductal Gray; Rats, Wistar; Tetrahydrocannabinol (THC); Antinociceptive descending pathway; URB597; Morphine tolerance; NP; MPE; Tetrahydrocannabinol (THC); RVM; SR 141716A; WIN 55,212-2; PWT; HU-210; THC; Neuropathic pain; AUC; MOR; vlPAG; Cannabis; PAG; GABA; GPCR; GIRK; CB1R

Neuropathic pain (NP) is often treated with opioids, the prolonged use of which causes tolerance to their analgesic effect and can potentially cause death by overdose. The phytocannabinoid delta-9-tetrahydrocannabinol (THC) may be an effective alternative analgesic to treat NP in morphine-tolerant s...