Impacts of Smoking and Stomach Disorders on Essential Elements in Biological Samples of Cement and Glass Industrial Workers

• Published in: Biological trace element research Vol. 201; no. 3; pp. 1065 - 1079
• Main Authors: Parveen, Sadaf, Imran Afridi, Hassan, Gul Kazi, Tasneem, Talpur, Farah Naz, Ahmed Baig, Jameel, Qadir Chanihoon, Ghulam, Memon, Ahsan Ali, Rahoojo, Almas
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer Nature B.V
• Subjects: Absorption; Acid digestion; Adult; atomic absorption spectrometry; Biochemistry; Biological properties; Biological samples; Biomedical and Life Sciences; Biotechnology; blood; Cadmium; Cadmium - analysis; Cement; Concrete; copper; Disorders; Drinking water; Drinking Water - analysis; Glass; hairs; Heavy metals; Helicobacter pylori; Humans; Immunology; Industrial areas; Iron; Irritable bowel syndrome; Lead; Lead - analysis; Life Sciences; Male; males; Metabolism; Metal concentrations; Middle Aged; Nutrition; Occupational exposure; Oncology; Scalp; Smoking; Spectral analysis; Spectrophotometry, Atomic - methods; Stomach; Stomach - chemistry; stomach ulcers; Toxicity; Trace elements; Trace Elements - analysis; Treated water; Ulcers; Vulnerability; wet digestion method; Workers; Zinc; Drinking water; Smoker and nonsmokers; Atomic absorption spectrophotometer; Stomach disorders; Biological samples; Workers of cement and glass industries
• DOI: 10.1007/s12011-022-03238-y
• ISSN: 0163-4984; 1559-0720

The infection caused by Helicobacter pylori ( H. pylori ) disrupts the metabolism and absorption of essential trace elements. Stomach disorders are related to changes in essential trace element metabolism caused by increased toxic metal exposure and H. pylori infection. The aim of the work is to link the development of stomach-related illnesses to an imbalance of essential trace and toxic metals. We have investigated the variations in essential trace elements such zinc (Zn), iron (Fe), and copper and toxic metals like lead (Pb) and cadmium (Cd) in biological (scalp hair, blood) samples of glass and cement workers. The study participants are further divided into smokers and nonsmokers, as well as diseased (gastric ulcer, irritable bowel syndrome, and chronic ulcer) and exposed referents (non-diseased industrial workers). Biological samples of age-matched (40–60 years) male subjects living in non-industrial areas were gathered for comparative purposes. After a pre-concentration method, the drinking water of industrial and domestic areas was analysed for both toxic metals. Microwave-aided acid digestion was used to oxidise the matrices of biological samples before atomic absorption spectrometer analysis of selected metals. Toxic metal levels in both industries’ drinking water were much higher than those found in domestically treated water ( p  < 0.01). Industrial workers suffering different types of stomach disorders have two to three times higher Pb and Cd concentrations than age-matched referents. Toxic metals are found in higher concentrations in smoker referents and diseased patients’ biological samples than in nonsmoker subjects. The findings of this study suggested that Pb and Cd toxicity’s immunological effects may be associated to an increased vulnerability to chronic infections.