Trisomy 18 Trends over the Last 20 Years
To evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children, using a large inpatient database. A retrospective analysis using the Kids’ Inpatient Database from 1997 to 2016 was performed for trisomy 18. We evalu...
Saved in:
Published in | The Journal of pediatrics Vol. 239; pp. 206 - 211.e1 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.12.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | To evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children, using a large inpatient database.
A retrospective analysis using the Kids’ Inpatient Database from 1997 to 2016 was performed for trisomy 18. We evaluated survival to discharge as well as the presence of pulmonary, skeletal, neurologic, gastrointestinal, renal, and hematologic/bleeding problems. We also searched for the following interventions, if performed: gastrostomy tube placement, tracheostomy, or cardiac procedure.
Over this period 10 151 admissions occurred in children with a diagnosis of trisomy 18. Between 1997 and 2016, the number of children admitted annually with trisomy 18 increased 74% from 1036 to 1798. The proportion of patients born prematurely remained stable at 14%-16% throughout the study. Gastrostomy tube placement increased 12-fold during the study period, tracheostomy increased 11-fold, and cardiac intervention increased 5-fold. The overall mortality rate decreased in those with trisomy 18 from 32% in 1997 to 21% in 2016.
We highlight a decreased inpatient mortality rate during the study period. The number of children undergoing interventions such as gastrostomy tube and tracheostomy increased, as did the number of children undergoing cardiac intervention. Although the number of procedures has increased with the mortality rate decreasing, it is unclear at present whether the 2 are related. |
---|---|
AbstractList | OBJECTIVETo evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children, using a large inpatient database. STUDY DESIGNA retrospective analysis using the Kids' Inpatient Database from 1997 to 2016 was performed for trisomy 18. We evaluated survival to discharge as well as the presence of pulmonary, skeletal, neurologic, gastrointestinal, renal, and hematologic/bleeding problems. We also searched for the following interventions, if performed: gastrostomy tube placement, tracheostomy, or cardiac procedure. RESULTSOver this period 10 151 admissions occurred in children with a diagnosis of trisomy 18. Between 1997 and 2016, the number of children admitted annually with trisomy 18 increased 74% from 1036 to 1798. The proportion of patients born prematurely remained stable at 14%-16% throughout the study. Gastrostomy tube placement increased 12-fold during the study period, tracheostomy increased 11-fold, and cardiac intervention increased 5-fold. The overall mortality rate decreased in those with trisomy 18 from 32% in 1997 to 21% in 2016. CONCLUSIONSWe highlight a decreased inpatient mortality rate during the study period. The number of children undergoing interventions such as gastrostomy tube and tracheostomy increased, as did the number of children undergoing cardiac intervention. Although the number of procedures has increased with the mortality rate decreasing, it is unclear at present whether the 2 are related. To evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children, using a large inpatient database. A retrospective analysis using the Kids’ Inpatient Database from 1997 to 2016 was performed for trisomy 18. We evaluated survival to discharge as well as the presence of pulmonary, skeletal, neurologic, gastrointestinal, renal, and hematologic/bleeding problems. We also searched for the following interventions, if performed: gastrostomy tube placement, tracheostomy, or cardiac procedure. Over this period 10 151 admissions occurred in children with a diagnosis of trisomy 18. Between 1997 and 2016, the number of children admitted annually with trisomy 18 increased 74% from 1036 to 1798. The proportion of patients born prematurely remained stable at 14%-16% throughout the study. Gastrostomy tube placement increased 12-fold during the study period, tracheostomy increased 11-fold, and cardiac intervention increased 5-fold. The overall mortality rate decreased in those with trisomy 18 from 32% in 1997 to 21% in 2016. We highlight a decreased inpatient mortality rate during the study period. The number of children undergoing interventions such as gastrostomy tube and tracheostomy increased, as did the number of children undergoing cardiac intervention. Although the number of procedures has increased with the mortality rate decreasing, it is unclear at present whether the 2 are related. |
Author | Fick, Tyler A. Sexson Tejtel, S. Kristen |
Author_xml | – sequence: 1 givenname: Tyler A. surname: Fick fullname: Fick, Tyler A. email: tyler.fick@bcm.edu – sequence: 2 givenname: S. Kristen surname: Sexson Tejtel fullname: Sexson Tejtel, S. Kristen |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34363815$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kLtOw0AQRVcoiDzgC5CQSyhsZp_2FhQo4iVFogkF1WrtnRWOEjvsOkj5G76FL8MhgZJqmnPnzpwxGTRtg4ScU8goUHW9yBZrdDFjwGgGeQaKHZERBZ2nquB8QEYAjKVc5GpIxjEuAEALgBMy5IIrXlA5IlfzUMd2tU1okcwDNi4m7QeGpHvDZGZjlzD4-nxFG-IpOfZ2GfHsMCfk5f5uPn1MZ88PT9PbWVpxqbvUSSFEwUtdeOG9Vl4WStPClVY4lWvLuLSUl8J5pcEy10PSc2S2P6nyIPmEXO73rkP7vsHYmVUdK1wubYPtJhompRZMMsZ6lO_RKrQxBvRmHeqVDVtDwewcmYX5cWR2jgzkpnfUpy4OBZtyhe4v8yulB272APZvftQYTKxqbCp0dcCqM66t_y34BrAmeI0 |
CitedBy_id | crossref_primary_10_1186_s12887_023_04237_1 crossref_primary_10_1097_MCD_0000000000000481 crossref_primary_10_36290_ped_2023_033 crossref_primary_10_46563_1560_9561_2022_25_3_212_216 crossref_primary_10_1016_j_bja_2023_02_022 crossref_primary_10_1590_1984_0462_2024_42_2023053 crossref_primary_10_1016_j_jpedsurg_2023_10_013 crossref_primary_10_1111_pan_14415 |
Cites_doi | 10.1161/JAHA.119.012349 10.1002/ajmg.c.31526 10.1001/jama.2016.9819 10.1002/ajmg.1320140409 10.1002/ajmg.1320490204 10.1002/ajmg.c.31525 10.1007/s00246-020-02444-6 10.1002/ajmg.a.61370 10.1007/s00246-018-2001-x 10.1007/s00431-019-03531-4 10.1002/ajmg.a.37495 10.1002/ajmg.a.37427 10.1002/ajmg.a.32311 10.1002/jgc4.1089 10.1542/peds.2007-1869 10.1017/S1047951120004023 10.1002/ajmg.a.61146 10.1002/ajmg.1320490203 10.1542/peds.2012-0151 10.1002/ajmg.a.31382 10.1542/peds.2012-3643 10.1007/s00246-018-2032-3 10.1542/peds.2017-0772 10.1542/peds.106.3.e29 10.1002/ajmg.a.62044 10.1007/s00246-015-1109-5 10.1002/ajmg.a.36127 10.1053/j.semperi.2015.12.015 10.1542/peds.2011-2139 10.1002/ajmg.a.31535 10.1002/ajmg.a.33156 10.1002/ajmg.c.31522 10.1016/j.athoracsur.2017.02.068 10.1016/j.amjcard.2003.12.012 10.1177/2150135118782145 |
ContentType | Journal Article |
Copyright | 2021 Elsevier Inc. Copyright © 2021 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2021 Elsevier Inc. – notice: Copyright © 2021 Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.jpeds.2021.07.062 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1097-6833 |
EndPage | 211.e1 |
ExternalDocumentID | 10_1016_j_jpeds_2021_07_062 34363815 S002234762100754X |
Genre | Journal Article |
GeographicLocations | United States |
GeographicLocations_xml | – name: United States |
GroupedDBID | --- --K --M -ET -RU .1- .55 .FO .GJ .XZ .~1 0R~ 123 1B1 1CY 1P~ 1RT 1~. 1~5 354 3O- 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 85S 8P~ 9JM AACTN AAEDT AAEDW AAEJM AAIAV AAIKC AAIKJ AAKOC AALRI AAMNW AAOAW AAQFI AAQQT AAQXK AAWTL AAXUO AAYJJ ABBQC ABFNM ABFRF ABIVO ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABPPZ ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNCT ACRLP ACRZS ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFDAS AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGNAY AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJJEV AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 C5W CAG COF CS3 DU5 EBS EFJIC EFLBG EJD EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q G8K GBLVA HEF HMK HMO HVGLF HZ~ IHE J1W K-O KOM L7B LCYCR M27 M32 M41 MO0 N4W N9A NEJ NQ- O-L O9- OAUVE OB2 OBH OH- OHH OHT OT- OVD P-8 P-9 P2P PC. PQQKQ Q38 R2- RIG ROL RPZ SAE SDF SEL SES SEW SJN SPCBC SSH SSZ T5K TEORI TWZ UGJ UHB UHS UKR UV1 VH1 VVN WH7 WOW WUQ X7M XCE XFW XOL YCJ YFH YOC YOJ YQJ YZZ Z5R ZA5 ZGI ZQV ZXP ZY1 ~G- ~KM AAXKI AFCTW AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX ABDPE ACRPL ADNMO CITATION 7X8 |
ID | FETCH-LOGICAL-c359t-d544483b98f4ff96f586918dba4d679a235a13b4df690a2d4ff5f3e2a436cf053 |
IEDL.DBID | AIKHN |
ISSN | 0022-3476 |
IngestDate | Tue Dec 03 23:20:07 EST 2024 Fri Dec 06 06:33:47 EST 2024 Sat Sep 28 08:29:46 EDT 2024 Fri Feb 23 02:44:56 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | ICD-9 ICD-10 hospitalization pediatrics HCUP KID trisomy 18 |
Language | English |
License | Copyright © 2021 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c359t-d544483b98f4ff96f586918dba4d679a235a13b4df690a2d4ff5f3e2a436cf053 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 34363815 |
PQID | 2559425222 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_2559425222 crossref_primary_10_1016_j_jpeds_2021_07_062 pubmed_primary_34363815 elsevier_sciencedirect_doi_10_1016_j_jpeds_2021_07_062 |
PublicationCentury | 2000 |
PublicationDate | December 2021 2021-12-00 20211201 |
PublicationDateYYYYMMDD | 2021-12-01 |
PublicationDate_xml | – month: 12 year: 2021 text: December 2021 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of pediatrics |
PublicationTitleAlternate | J Pediatr |
PublicationYear | 2021 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Janvier, Farlow, Wilfond (bib14) 2012; 130 Kosiv, Long, Lee, Collins (bib30) 2021; 185 Cooper, Riggs, Zafar, Jacobs, Hill, Pasquali (bib7) 2019; 8 Weaver, Lantos, Hauschild, Hammel, Birge, Janvier (bib34) 2020; 31 Bruns, Martinez (bib20) 2016; 170 Graham (bib24) 2007 Kaneko, Kobayashi, Yamamoto, Yoda, Kanetaka, Nakajima (bib18) 2008; 146A Niermeyer, Kattwinkel, Van Reempts, Nadkarni, Phillips, Zideman (bib11) 2000; 106 Carvajal, Callahan, Miller, Rensink, Eghtesady (bib27) 2020; 41 Donovan, Krigbaum, Bruns (bib29) 2016; 172 Peterson, Kochilas, Catton, Moller, Setty (bib6) 2017; 103 Ma, He, Benavidez (bib5) 2019; 40 Kato, Kitase, Tachibana, Hattori, Saito, Muramatsu (bib19) 2019; 179 Meyer, Liu, Gilboa, Ethen, Aylsworth, Powell (bib28) 2016; 170 Costello, Weiderhold, Louis, Shaughnessy, Peer, Zurakowski (bib32) 2015; 36 Carey (bib15) 2020; 182 Davisson, Clark, Chin, Tunks (bib33) 2018; 9 Wu, Springett, Morris (bib10) 2013; 161 Boss, Holmes, Althaus, Rushton, McNee, McNee (bib36) 2013; 132 Nelson, Rosella, Mahant, Guttmann (bib22) 2016; 316 Pont, Robbins, Bird, Gibson, Cleves, Tilford (bib25) 2006; 140 Nelson, Hexem, Feudtner (bib21) 2012; 129 Matsuoka, Misugi, Goto, Gilbert, Ando (bib8) 1983; 14 Milligan, Jackson, Maurer (bib37) 2020; 2 Silberberg, Robetto, Grimaux, Nucifora, Moreno Villares (bib16) 2020; 179 Tucker, Garringer, Weaver (bib31) 2007; 143A Kaulfus, Gardiner, Hashmi, Mendez-Figueroa, Miller, Stevens (bib17) 2019; 28 Kosiv, Gossett, Bai, Thomas Collins (bib3) 2017; 140 Josephsen, Armbrecht, Braddock, Cibulskis (bib23) 2016; 172 Janvier, Farlow, Barrington (bib35) 2016; 172 Root, Carey (bib1) 1994; 49 Baty, Blackburn, Carey (bib2) 1994; 49 Domingo, Carey, Eckhauser, Wilkes, Menon (bib4) 2019; 40 Janvier, Farlow, Barrington (bib13) 2016; 40 Vendola, Canfield, Daiger, Gambello, Shahrukh Hashmi, King (bib9) 2010; 152A McGraw, Perlman (bib12) 2008; 121 Graham, Bradley, Shirali, Hills, Atz (bib26) 2004; 93 Janvier (10.1016/j.jpeds.2021.07.062_bib14) 2012; 130 Tucker (10.1016/j.jpeds.2021.07.062_bib31) 2007; 143A Kosiv (10.1016/j.jpeds.2021.07.062_bib3) 2017; 140 Domingo (10.1016/j.jpeds.2021.07.062_bib4) 2019; 40 McGraw (10.1016/j.jpeds.2021.07.062_bib12) 2008; 121 Ma (10.1016/j.jpeds.2021.07.062_bib5) 2019; 40 Davisson (10.1016/j.jpeds.2021.07.062_bib33) 2018; 9 Niermeyer (10.1016/j.jpeds.2021.07.062_bib11) 2000; 106 Root (10.1016/j.jpeds.2021.07.062_bib1) 1994; 49 Carey (10.1016/j.jpeds.2021.07.062_bib15) 2020; 182 Boss (10.1016/j.jpeds.2021.07.062_bib36) 2013; 132 Matsuoka (10.1016/j.jpeds.2021.07.062_bib8) 1983; 14 Nelson (10.1016/j.jpeds.2021.07.062_bib21) 2012; 129 Weaver (10.1016/j.jpeds.2021.07.062_bib34) 2020; 31 Janvier (10.1016/j.jpeds.2021.07.062_bib35) 2016; 172 Peterson (10.1016/j.jpeds.2021.07.062_bib6) 2017; 103 Vendola (10.1016/j.jpeds.2021.07.062_bib9) 2010; 152A Graham (10.1016/j.jpeds.2021.07.062_bib26) 2004; 93 Milligan (10.1016/j.jpeds.2021.07.062_bib37) 2020; 2 Silberberg (10.1016/j.jpeds.2021.07.062_bib16) 2020; 179 Nelson (10.1016/j.jpeds.2021.07.062_bib22) 2016; 316 Carvajal (10.1016/j.jpeds.2021.07.062_bib27) 2020; 41 Janvier (10.1016/j.jpeds.2021.07.062_bib13) 2016; 40 Pont (10.1016/j.jpeds.2021.07.062_bib25) 2006; 140 Kaulfus (10.1016/j.jpeds.2021.07.062_bib17) 2019; 28 Bruns (10.1016/j.jpeds.2021.07.062_bib20) 2016; 170 Kato (10.1016/j.jpeds.2021.07.062_bib19) 2019; 179 Kaneko (10.1016/j.jpeds.2021.07.062_bib18) 2008; 146A Josephsen (10.1016/j.jpeds.2021.07.062_bib23) 2016; 172 Meyer (10.1016/j.jpeds.2021.07.062_bib28) 2016; 170 Graham (10.1016/j.jpeds.2021.07.062_bib24) 2007 Wu (10.1016/j.jpeds.2021.07.062_bib10) 2013; 161 Cooper (10.1016/j.jpeds.2021.07.062_bib7) 2019; 8 Costello (10.1016/j.jpeds.2021.07.062_bib32) 2015; 36 Donovan (10.1016/j.jpeds.2021.07.062_bib29) 2016; 172 Kosiv (10.1016/j.jpeds.2021.07.062_bib30) 2021; 185 Baty (10.1016/j.jpeds.2021.07.062_bib2) 1994; 49 |
References_xml | – volume: 161 start-page: 2512 year: 2013 end-page: 2518 ident: bib10 article-title: Survival of trisomy 18 (Edwards syndrome) and trisomy 13 (Patau Syndrome) in England and Wales: 2004-2011 publication-title: Am J Med Genet Part A contributor: fullname: Morris – year: 2007 ident: bib24 article-title: Smith’s recognizable patterns of human deformation publication-title: Smith’s Recognizable patterns of human deformation contributor: fullname: Graham – volume: 130 start-page: 293 year: 2012 end-page: 298 ident: bib14 article-title: The experience of families with children with trisomy 13 and 18 in social networks publication-title: Pediatrics contributor: fullname: Wilfond – volume: 93 start-page: 801 year: 2004 end-page: 803 ident: bib26 article-title: Effectiveness of cardiac surgery in trisomies 13 and 18 (from the Pediatric Cardiac Care Consortium) publication-title: Am J Cardiol contributor: fullname: Atz – volume: 140 start-page: e20170772 year: 2017 ident: bib3 article-title: Congenital heart surgery on in-hospital mortality in trisomy 13 and 18 publication-title: Pediatrics contributor: fullname: Thomas Collins – volume: 28 start-page: 654 year: 2019 end-page: 663 ident: bib17 article-title: Attitudes of clinicians toward cardiac surgery and trisomy 18 publication-title: J Genet Couns contributor: fullname: Stevens – volume: 40 start-page: 349 year: 2019 end-page: 356 ident: bib4 article-title: Mortality and resource use following cardiac interventions in children with trisomy 13 and trisomy 18 and congenital heart disease publication-title: Pediatr Cardiol contributor: fullname: Menon – volume: 31 start-page: 471 year: 2020 end-page: 475 ident: bib34 article-title: Communicating with parents of children with trisomy 13 or 18 who seek cardiac interventions publication-title: Cardiol Young contributor: fullname: Janvier – volume: 121 start-page: 1106 year: 2008 end-page: 1110 ident: bib12 article-title: Attitudes of neonatologists toward delivery room management of confirmed trisomy 18: potential factors influencing a changing dynamic publication-title: Pediatrics contributor: fullname: Perlman – volume: 40 start-page: 595 year: 2019 end-page: 601 ident: bib5 article-title: Congenital heart surgical admissions in patients with trisomy 13 and 18: frequency, morbidity, and mortality publication-title: Pediatr Cardiol contributor: fullname: Benavidez – volume: 103 start-page: 1941 year: 2017 end-page: 1949 ident: bib6 article-title: Long-Term outcomes of children with trisomy 13 and 18 after congenital heart disease interventions publication-title: Ann Thorac Surg contributor: fullname: Setty – volume: 132 start-page: 161 year: 2013 end-page: 165 ident: bib36 article-title: Ethics rounds: Trisomy 18 and complex congenital heart disease: seeking the threshold benefit publication-title: Pediatrics contributor: fullname: McNee – volume: 152A start-page: 360 year: 2010 end-page: 366 ident: bib9 article-title: Survival of Texas infants born with trisomies 21, 18, and 13 publication-title: Am J Med Genet Part A contributor: fullname: King – volume: 129 start-page: 869 year: 2012 end-page: 876 ident: bib21 article-title: Inpatient hospital care of children with trisomy 13 and trisomy 18 in the United States publication-title: Pediatrics contributor: fullname: Feudtner – volume: 140 start-page: 1749 year: 2006 end-page: 1756 ident: bib25 article-title: Congenital malformations among liveborn infants with trisomies 18 and 13 publication-title: Am J Med Genet Part A contributor: fullname: Tilford – volume: 9 start-page: 550 year: 2018 end-page: 556 ident: bib33 article-title: Trisomy 18 and congenital heart disease: single-center review of outcomes and parental perspectives publication-title: World J Pediatr Congenit Heart Surg contributor: fullname: Tunks – volume: 316 start-page: 420 year: 2016 end-page: 428 ident: bib22 article-title: Survival and surgical interventions for children with trisomy 13 and 18 publication-title: JAMA contributor: fullname: Guttmann – volume: 172 start-page: 279 year: 2016 end-page: 287 ident: bib35 article-title: Parental hopes, interventions, and survival of neonates with trisomy 13 and trisomy 18 publication-title: Am J Med Genet Part C Semin Med Genet contributor: fullname: Barrington – volume: 49 start-page: 170 year: 1994 end-page: 174 ident: bib1 article-title: Survival in trisomy 18 publication-title: Am J Med Genet contributor: fullname: Carey – volume: 146A start-page: 1372 year: 2008 end-page: 1380 ident: bib18 article-title: Intensive cardiac management in patients with trisomy 13 or trisomy 18 publication-title: Am J Med Genet Part A contributor: fullname: Nakajima – volume: 172 start-page: 264 year: 2016 end-page: 271 ident: bib23 article-title: Procedures in the 1st year of life for children with trisomy 13 and trisomy 18, a 25-year, single-center review publication-title: Am J Med Genet Part C Semin Med Genet contributor: fullname: Cibulskis – volume: 143A start-page: 505 year: 2007 end-page: 517 ident: bib31 article-title: Phenotypic spectrum of mosaic trisomy 18: two new patients, a literature review, and counseling issues publication-title: Am J Med Genet Part A contributor: fullname: Weaver – volume: 185 start-page: 806 year: 2021 end-page: 813 ident: bib30 article-title: A validated model for prediction of survival to 6 months in patients with trisomy 13 and 18 publication-title: Am J Med Genet Part A contributor: fullname: Collins – volume: 49 start-page: 175 year: 1994 end-page: 188 ident: bib2 article-title: Natural history of trisomy 18 and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk publication-title: Am J Med Genet contributor: fullname: Carey – volume: 8 start-page: e012349 year: 2019 ident: bib7 article-title: Cardiac surgery in patients with trisomy 13 and 18: an analysis of the society of thoracic surgeons congenital heart surgery database publication-title: J Am Heart Assoc contributor: fullname: Pasquali – volume: 182 start-page: 13 year: 2020 end-page: 14 ident: bib15 article-title: Emerging evidence that medical and surgical interventions improve the survival and outcome in the trisomy 13 and 18 syndromes publication-title: Am J Med Genet Part A contributor: fullname: Carey – volume: 172 start-page: 272 year: 2016 end-page: 278 ident: bib29 article-title: Medical interventions and survival by gender of children with trisomy 18 publication-title: Am J Med Genet Part C Semin Med Genet contributor: fullname: Bruns – volume: 170 start-page: 337 year: 2016 end-page: 343 ident: bib20 article-title: An analysis of cardiac defects and surgical interventions in 84 cases with full trisomy 18 publication-title: Am J Med Genet Part A contributor: fullname: Martinez – volume: 41 start-page: 1319 year: 2020 end-page: 1333 ident: bib27 article-title: Cardiac surgery in trisomy 13 and 18: a guide to clinical decision-making publication-title: Pediatr Cardiol contributor: fullname: Eghtesady – volume: 170 start-page: 825 year: 2016 end-page: 837 ident: bib28 article-title: Survival of children with trisomy 13 and trisomy 18: a multistate population-based study publication-title: Am J Med Genet Part A contributor: fullname: Powell – volume: 36 start-page: 987 year: 2015 end-page: 992 ident: bib32 article-title: A contemporary, single-institutional experience of surgical versus expectant management of congenital heart disease in trisomy 13 and 18 patients publication-title: Pediatr Cardiol contributor: fullname: Zurakowski – volume: 106 start-page: E29 year: 2000 ident: bib11 article-title: International Guidelines for Neonatal Resuscitation: an excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and Reviewers for the Neonatal Resuscitation Gui publication-title: Pediatrics contributor: fullname: Zideman – volume: 2 start-page: 1 year: 2020 end-page: 5 ident: bib37 article-title: Clinical course for patients with trisomy 13 and 18 pursuing life-prolonging therapies versus comfort-directed care publication-title: Am J Hosp Palliat Med contributor: fullname: Maurer – volume: 179 start-page: 1253 year: 2019 end-page: 1259 ident: bib19 article-title: Factors related to survival discharge in trisomy 18: a retrospective multicenter study publication-title: Am J Med Genet Part A contributor: fullname: Muramatsu – volume: 14 start-page: 657 year: 1983 end-page: 668 ident: bib8 article-title: Congenital heart anomalies in the trisomy 18 syndrome, with reference to congenital polyvalvular disease publication-title: Am J Med Genet contributor: fullname: Ando – volume: 40 start-page: 254 year: 2016 end-page: 260 ident: bib13 article-title: Cardiac surgery for children with trisomies 13 and 18: where are we now? publication-title: Semin Perinatol contributor: fullname: Barrington – volume: 179 start-page: 493 year: 2020 end-page: 497 ident: bib16 article-title: Ethical issues about the paradigm shift in the treatment of children with trisomy 18 publication-title: Eur J Pediatr contributor: fullname: Moreno Villares – volume: 8 start-page: e012349 year: 2019 ident: 10.1016/j.jpeds.2021.07.062_bib7 article-title: Cardiac surgery in patients with trisomy 13 and 18: an analysis of the society of thoracic surgeons congenital heart surgery database publication-title: J Am Heart Assoc doi: 10.1161/JAHA.119.012349 contributor: fullname: Cooper – volume: 172 start-page: 279 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib35 article-title: Parental hopes, interventions, and survival of neonates with trisomy 13 and trisomy 18 publication-title: Am J Med Genet Part C Semin Med Genet doi: 10.1002/ajmg.c.31526 contributor: fullname: Janvier – volume: 316 start-page: 420 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib22 article-title: Survival and surgical interventions for children with trisomy 13 and 18 publication-title: JAMA doi: 10.1001/jama.2016.9819 contributor: fullname: Nelson – volume: 14 start-page: 657 year: 1983 ident: 10.1016/j.jpeds.2021.07.062_bib8 article-title: Congenital heart anomalies in the trisomy 18 syndrome, with reference to congenital polyvalvular disease publication-title: Am J Med Genet doi: 10.1002/ajmg.1320140409 contributor: fullname: Matsuoka – volume: 49 start-page: 175 year: 1994 ident: 10.1016/j.jpeds.2021.07.062_bib2 article-title: Natural history of trisomy 18 and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk publication-title: Am J Med Genet doi: 10.1002/ajmg.1320490204 contributor: fullname: Baty – volume: 172 start-page: 264 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib23 article-title: Procedures in the 1st year of life for children with trisomy 13 and trisomy 18, a 25-year, single-center review publication-title: Am J Med Genet Part C Semin Med Genet doi: 10.1002/ajmg.c.31525 contributor: fullname: Josephsen – volume: 41 start-page: 1319 year: 2020 ident: 10.1016/j.jpeds.2021.07.062_bib27 article-title: Cardiac surgery in trisomy 13 and 18: a guide to clinical decision-making publication-title: Pediatr Cardiol doi: 10.1007/s00246-020-02444-6 contributor: fullname: Carvajal – volume: 182 start-page: 13 year: 2020 ident: 10.1016/j.jpeds.2021.07.062_bib15 article-title: Emerging evidence that medical and surgical interventions improve the survival and outcome in the trisomy 13 and 18 syndromes publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.61370 contributor: fullname: Carey – year: 2007 ident: 10.1016/j.jpeds.2021.07.062_bib24 article-title: Smith’s recognizable patterns of human deformation contributor: fullname: Graham – volume: 40 start-page: 349 year: 2019 ident: 10.1016/j.jpeds.2021.07.062_bib4 article-title: Mortality and resource use following cardiac interventions in children with trisomy 13 and trisomy 18 and congenital heart disease publication-title: Pediatr Cardiol doi: 10.1007/s00246-018-2001-x contributor: fullname: Domingo – volume: 179 start-page: 493 year: 2020 ident: 10.1016/j.jpeds.2021.07.062_bib16 article-title: Ethical issues about the paradigm shift in the treatment of children with trisomy 18 publication-title: Eur J Pediatr doi: 10.1007/s00431-019-03531-4 contributor: fullname: Silberberg – volume: 170 start-page: 825 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib28 article-title: Survival of children with trisomy 13 and trisomy 18: a multistate population-based study publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.37495 contributor: fullname: Meyer – volume: 170 start-page: 337 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib20 article-title: An analysis of cardiac defects and surgical interventions in 84 cases with full trisomy 18 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.37427 contributor: fullname: Bruns – volume: 146A start-page: 1372 year: 2008 ident: 10.1016/j.jpeds.2021.07.062_bib18 article-title: Intensive cardiac management in patients with trisomy 13 or trisomy 18 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.32311 contributor: fullname: Kaneko – volume: 28 start-page: 654 year: 2019 ident: 10.1016/j.jpeds.2021.07.062_bib17 article-title: Attitudes of clinicians toward cardiac surgery and trisomy 18 publication-title: J Genet Couns doi: 10.1002/jgc4.1089 contributor: fullname: Kaulfus – volume: 121 start-page: 1106 year: 2008 ident: 10.1016/j.jpeds.2021.07.062_bib12 article-title: Attitudes of neonatologists toward delivery room management of confirmed trisomy 18: potential factors influencing a changing dynamic publication-title: Pediatrics doi: 10.1542/peds.2007-1869 contributor: fullname: McGraw – volume: 31 start-page: 471 year: 2020 ident: 10.1016/j.jpeds.2021.07.062_bib34 article-title: Communicating with parents of children with trisomy 13 or 18 who seek cardiac interventions publication-title: Cardiol Young doi: 10.1017/S1047951120004023 contributor: fullname: Weaver – volume: 179 start-page: 1253 year: 2019 ident: 10.1016/j.jpeds.2021.07.062_bib19 article-title: Factors related to survival discharge in trisomy 18: a retrospective multicenter study publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.61146 contributor: fullname: Kato – volume: 49 start-page: 170 year: 1994 ident: 10.1016/j.jpeds.2021.07.062_bib1 article-title: Survival in trisomy 18 publication-title: Am J Med Genet doi: 10.1002/ajmg.1320490203 contributor: fullname: Root – volume: 130 start-page: 293 year: 2012 ident: 10.1016/j.jpeds.2021.07.062_bib14 article-title: The experience of families with children with trisomy 13 and 18 in social networks publication-title: Pediatrics doi: 10.1542/peds.2012-0151 contributor: fullname: Janvier – volume: 140 start-page: 1749 year: 2006 ident: 10.1016/j.jpeds.2021.07.062_bib25 article-title: Congenital malformations among liveborn infants with trisomies 18 and 13 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.31382 contributor: fullname: Pont – volume: 132 start-page: 161 year: 2013 ident: 10.1016/j.jpeds.2021.07.062_bib36 article-title: Ethics rounds: Trisomy 18 and complex congenital heart disease: seeking the threshold benefit publication-title: Pediatrics doi: 10.1542/peds.2012-3643 contributor: fullname: Boss – volume: 40 start-page: 595 year: 2019 ident: 10.1016/j.jpeds.2021.07.062_bib5 article-title: Congenital heart surgical admissions in patients with trisomy 13 and 18: frequency, morbidity, and mortality publication-title: Pediatr Cardiol doi: 10.1007/s00246-018-2032-3 contributor: fullname: Ma – volume: 140 start-page: e20170772 year: 2017 ident: 10.1016/j.jpeds.2021.07.062_bib3 article-title: Congenital heart surgery on in-hospital mortality in trisomy 13 and 18 publication-title: Pediatrics doi: 10.1542/peds.2017-0772 contributor: fullname: Kosiv – volume: 106 start-page: E29 year: 2000 ident: 10.1016/j.jpeds.2021.07.062_bib11 article-title: International Guidelines for Neonatal Resuscitation: an excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and Reviewers for the Neonatal Resuscitation Gui publication-title: Pediatrics doi: 10.1542/peds.106.3.e29 contributor: fullname: Niermeyer – volume: 2 start-page: 1 year: 2020 ident: 10.1016/j.jpeds.2021.07.062_bib37 article-title: Clinical course for patients with trisomy 13 and 18 pursuing life-prolonging therapies versus comfort-directed care publication-title: Am J Hosp Palliat Med contributor: fullname: Milligan – volume: 185 start-page: 806 year: 2021 ident: 10.1016/j.jpeds.2021.07.062_bib30 article-title: A validated model for prediction of survival to 6 months in patients with trisomy 13 and 18 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.62044 contributor: fullname: Kosiv – volume: 36 start-page: 987 year: 2015 ident: 10.1016/j.jpeds.2021.07.062_bib32 article-title: A contemporary, single-institutional experience of surgical versus expectant management of congenital heart disease in trisomy 13 and 18 patients publication-title: Pediatr Cardiol doi: 10.1007/s00246-015-1109-5 contributor: fullname: Costello – volume: 161 start-page: 2512 year: 2013 ident: 10.1016/j.jpeds.2021.07.062_bib10 article-title: Survival of trisomy 18 (Edwards syndrome) and trisomy 13 (Patau Syndrome) in England and Wales: 2004-2011 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.36127 contributor: fullname: Wu – volume: 40 start-page: 254 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib13 article-title: Cardiac surgery for children with trisomies 13 and 18: where are we now? publication-title: Semin Perinatol doi: 10.1053/j.semperi.2015.12.015 contributor: fullname: Janvier – volume: 129 start-page: 869 year: 2012 ident: 10.1016/j.jpeds.2021.07.062_bib21 article-title: Inpatient hospital care of children with trisomy 13 and trisomy 18 in the United States publication-title: Pediatrics doi: 10.1542/peds.2011-2139 contributor: fullname: Nelson – volume: 143A start-page: 505 year: 2007 ident: 10.1016/j.jpeds.2021.07.062_bib31 article-title: Phenotypic spectrum of mosaic trisomy 18: two new patients, a literature review, and counseling issues publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.31535 contributor: fullname: Tucker – volume: 152A start-page: 360 year: 2010 ident: 10.1016/j.jpeds.2021.07.062_bib9 article-title: Survival of Texas infants born with trisomies 21, 18, and 13 publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.33156 contributor: fullname: Vendola – volume: 172 start-page: 272 year: 2016 ident: 10.1016/j.jpeds.2021.07.062_bib29 article-title: Medical interventions and survival by gender of children with trisomy 18 publication-title: Am J Med Genet Part C Semin Med Genet doi: 10.1002/ajmg.c.31522 contributor: fullname: Donovan – volume: 103 start-page: 1941 year: 2017 ident: 10.1016/j.jpeds.2021.07.062_bib6 article-title: Long-Term outcomes of children with trisomy 13 and 18 after congenital heart disease interventions publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2017.02.068 contributor: fullname: Peterson – volume: 93 start-page: 801 year: 2004 ident: 10.1016/j.jpeds.2021.07.062_bib26 article-title: Effectiveness of cardiac surgery in trisomies 13 and 18 (from the Pediatric Cardiac Care Consortium) publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2003.12.012 contributor: fullname: Graham – volume: 9 start-page: 550 year: 2018 ident: 10.1016/j.jpeds.2021.07.062_bib33 article-title: Trisomy 18 and congenital heart disease: single-center review of outcomes and parental perspectives publication-title: World J Pediatr Congenit Heart Surg doi: 10.1177/2150135118782145 contributor: fullname: Davisson |
SSID | ssj0009400 |
Score | 2.4469612 |
Snippet | To evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children, using a... OBJECTIVETo evaluate the trends in hospitalizations for children with trisomy 18 over time and to determine the rate of invasive procedures on these children,... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 206 |
SubjectTerms | Adolescent Cardiac Surgical Procedures - trends Child Child, Preschool Databases, Factual Female Gastrostomy - trends hospitalization Hospitalization - trends Humans Infant Infant, Newborn Male pediatrics Practice Patterns, Physicians' - trends Retrospective Studies Tracheostomy - trends trisomy 18 Trisomy 18 Syndrome - complications Trisomy 18 Syndrome - mortality Trisomy 18 Syndrome - surgery United States |
Title | Trisomy 18 Trends over the Last 20 Years |
URI | https://dx.doi.org/10.1016/j.jpeds.2021.07.062 https://www.ncbi.nlm.nih.gov/pubmed/34363815 https://search.proquest.com/docview/2559425222 |
Volume | 239 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB76APEivq2PEsGLYGyyrybHUiz10Z5aqKdlN8lCC7bFpgcv_hZ_i7_M2TwUD_XgKSTsks2X3ZlvmG9nAa4iykzgkcjVgkcuGjzPVVwTVwTa04oao7Ls-WAo-mP2MOGTCnTLvTBWVlnY_tymZ9a6eNIq0Gwtp1O7xxddG8PFbBP9nE2qUEd3ZHO19c79Y3_4U3uXFTtRrHAdO5TFhzKZ12yZxLZsN_GzIp6CbHJQmwho5oh6u7BTMEinkw9yDyrJfB-2BkWO_ACuR_ZYwZc3xw-cXPHqWJmmg0zPeVKr1CHe58czTvDVIYx7d6Nu3y0ORHAjysPUjTnDaIrqMDDMmFAYHojQD2KtWCzaoSKUK59qFhuMeRWJsRE3NCGKUREZXG5HUJsv5skJOERx30R-jJeAsZhooYRvkJ0pqkLttRtwU6Igl3ndC1kKwmYyA01a0KTXlghaA0SJlPz1-yRa5r87Xpa4SpzYNluh5slijY0w1kGDgvylAcc54N8jofhBSDX46X9fewbb9i7XpZxDLX1dJxfILlLdhOrtu98s5tAXAGDLaw |
link.rule.ids | 314,780,784,4502,24116,27924,27925,45585,45679 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB5qBfUivq3PCF4EY5N9NTlKsVRte2qhnpbdJAst2BabHrz4W_wt_jJn86h4qAdPgWRCdr_Mzn7LfDsLcB1RZgKPRK4WPHIx4Hmu4pq4ItCeVtQYlWXPuz3RHrCnIR9WoFnuhbGyyiL25zE9i9bFnXqBZn02Gtk9vji1MRzMNtHP2XAN1hlH9otOfffxo_OwJ38vS4ajeVl6KBN5jWdJbIt2Ez8r4SnIqulpFf3MpqHWDmwX_NG5z5u4C5Vksgcb3SJDvg83fXuo4Ou74wdOrnd1rEjTQZ7ndNQ8dYj39fmC7j0_gEHrod9su8VxCG5EeZi6MWe4lqI6DAwzJhSGByL0g1grFotGqAjlyqeaxQZXvIrEaMQNTYhiVEQGB9shVCfTSXIMDlHcN5Ef4yVgLCZaKOEb5GaKqlB7jRrclijIWV71QpZysLHMQJMWNOk1JIJWA1EiJX_9PIlx-e8Xr0pcJbq1zVWoSTJdoBGudDCcIHupwVEO-LIlFDuERIOf_Pezl7DZ7nc7svPYez6FLfskV6icQTV9WyTnyDNSfZH50TfOAcxE |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Trisomy+18+Trends+over+the+Last+20+Years&rft.jtitle=The+Journal+of+pediatrics&rft.au=Fick%2C+Tyler+A&rft.au=Sexson+Tejtel%2C+S+Kristen&rft.date=2021-12-01&rft.eissn=1097-6833&rft.volume=239&rft.spage=206&rft.epage=211.e1&rft_id=info:doi/10.1016%2Fj.jpeds.2021.07.062&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3476&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3476&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3476&client=summon |