Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway

• Published in: Immunology letters Vol. 258; pp. 35 - 44
• Main Authors: Liu, Yanzhuo, Yuan, Yinglin, Zhou, Zili, Jiang, Xiaomei, He, Shu, Wei, Fan, Cui, Yuanyuan, Yang, Lu, Zhao, Gaoping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2023
• Subjects: Animals; Cell Differentiation; Differential; Forkhead Transcription Factors - genetics; iTregs; Mice; mTOR; N6-methyladenosine; Signal Transduction; Suppressive function; T-Lymphocytes, Regulatory; TOR Serine-Threonine Kinases - metabolism; mTOR; Suppressive function; N6-methyladenosine; iTregs; Differential

•The m6A methyltransferase Mettl14 is involved in the generation of in vitro-induced Tregs (iTregs).•The methyltransferase Mettl14 is necessary for the maintenance of functional iTregs.•Mettl14-mediated m6A modification disrupted iTregs polarization by activating the mTOR-dependent pathway.•Our find...