Comparison of multiple doses of cyclosporine A on germ cell apoptosis and epididymal sperm parameters after testicular ischemia/reperfusion in rats

Testicular torsion/detorsion (T/D) is an inflammatory problem in men genital system with infertility effects. Cyclosporine A (CsA) as an immunosuppressant medication, exerts anti-inflammatory properties in tissue injuries. We sought to compare the efficacy of 3 doses of CsA on oxidative stress, apop...

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Published inExperimental and molecular pathology Vol. 110; p. 104271
Main Authors Yazdani, Iraj, Majdani, Raheleh, Ghasemnejad-berenji, Morteza, Dehpour, Ahmad Reza
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.10.2019
Subjects
Animals
Apoptosis
Apoptosis - drug effects
Caspase 3 - metabolism
Catalase - metabolism
Cyclosporine - pharmacology
Cyclosporine A
Epididymis - drug effects
Epididymis - metabolism
Epididymis - pathology
Germ cell
Germ Cells
Glutathione Peroxidase - metabolism
Immunosuppressive Agents - pharmacology
Male
Malondialdehyde - metabolism
Mitochondrial permeability transition pore
Oxidative Stress - drug effects
Rats, Wistar
Reperfusion Injury - physiopathology
Spermatic Cord Torsion - physiopathology
Spermatozoa - drug effects
Spermatozoa - pathology
Superoxide Dismutase - metabolism
Testicular T/D
Testis - blood supply
Testis - drug effects
Testis - metabolism
Germ cell
Cyclosporine A
Mitochondrial permeability transition pore
Testicular T/D
Apoptosis
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Abstract Testicular torsion/detorsion (T/D) is an inflammatory problem in men genital system with infertility effects. Cyclosporine A (CsA) as an immunosuppressant medication, exerts anti-inflammatory properties in tissue injuries. We sought to compare the efficacy of 3 doses of CsA on oxidative stress, apoptosis and epididymal sperm quality after ipsilateral testicular T/D. 96 mature male rats were divided into six groups 16 each in: Control group (Group1), Sham operated (Group2), In rest groups, the right testis was twisted 720° in a clockwise direction for 1 h; T/D + 0.1% dimethylsulfoxide) DMSO((Group3), and in groups 4–6; CsA were administered 1, 5, and 10 mg/kg, intravenously (iv) 30 and 90 min after torsion, respectively. Tissue malondialdehyde (MDA) level and caspase-3 activity increased and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased in compared with control group 4 h after detorsion (p < .001). In six rats of each group 24 h after detorsion, histopathological changes and germ cell apoptosis were significantly deteriorated by determining mean of seminiferous tubules diameters (MSTD) and TUNEL assay. Moreover, 30 days after T/D, sperm concentration and motility were examined in rest of animals. Pre- and post-reperfusion CsA diminished MDA and caspase-3levels and normalized antioxidant enzymes activities. Germ cell apoptosis was significantly reduced, as well as, MSTD and long-term sperm insults were improved. Inhibition of mitochondrial permeability transition pore opening is suggested mechanism for cell protection against testicular T/D insults.
AbstractList Testicular torsion/detorsion (T/D) is an inflammatory problem in men genital system with infertility effects. Cyclosporine A (CsA) as an immunosuppressant medication, exerts anti-inflammatory properties in tissue injuries. We sought to compare the efficacy of 3 doses of CsA on oxidative stress, apoptosis and epididymal sperm quality after ipsilateral testicular T/D. 96 mature male rats were divided into six groups 16 each in: Control group (Group1), Sham operated (Group2), In rest groups, the right testis was twisted 720° in a clockwise direction for 1 h; T/D + 0.1% dimethylsulfoxide) DMSO((Group3), and in groups 4–6; CsA were administered 1, 5, and 10 mg/kg, intravenously (iv) 30 and 90 min after torsion, respectively. Tissue malondialdehyde (MDA) level and caspase-3 activity increased and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased in compared with control group 4 h after detorsion (p < .001). In six rats of each group 24 h after detorsion, histopathological changes and germ cell apoptosis were significantly deteriorated by determining mean of seminiferous tubules diameters (MSTD) and TUNEL assay. Moreover, 30 days after T/D, sperm concentration and motility were examined in rest of animals. Pre- and post-reperfusion CsA diminished MDA and caspase-3levels and normalized antioxidant enzymes activities. Germ cell apoptosis was significantly reduced, as well as, MSTD and long-term sperm insults were improved. Inhibition of mitochondrial permeability transition pore opening is suggested mechanism for cell protection against testicular T/D insults.
ArticleNumber 104271
Author Majdani, Raheleh
Dehpour, Ahmad Reza
Yazdani, Iraj
Ghasemnejad-berenji, Morteza
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Cites_doi 10.1172/JCI118159
10.1007/s11255-008-9453-5
10.1074/jbc.M006825200
10.1016/S0076-6879(84)05016-3
10.1097/01.ju.0000144203.30718.19
10.1016/0014-5793(92)80616-O
10.1124/jpet.109.153213
10.1016/j.brainres.2011.11.055
10.1016/S0300-9084(02)01368-8
10.1007/s11064-013-0968-5
10.1016/j.mito.2009.10.001
10.1016/0003-2697(79)90738-3
10.1016/0076-6879(90)86110-H
10.1016/S0076-6879(96)64044-0
10.1111/and.12605
10.1016/j.yjmcc.2006.09.013
10.1016/S0300-9084(02)01381-0
10.1007/s00383-005-1580-9
10.1073/pnas.1401591111
10.1095/biolreprod65.3.718
10.1038/sj.bjp.0704908
10.1042/bj3410233
10.1002/j.1939-4640.1986.tb00862.x
10.1016/j.biopha.2018.06.012
10.1016/j.athoracsur.2008.06.033
10.1016/j.fertnstert.2009.01.146
10.1016/j.bbamcr.2010.09.013
10.1016/S0306-4522(00)00380-8
10.1007/s00345-008-0323-7
10.1006/clin.1996.0140
10.4161/cc.23599
10.1523/JNEUROSCI.18-10-03659.1998
10.1016/j.urology.2004.09.033
10.1385/BTER:93:1-3:141
10.1074/jbc.M310381200
10.1016/j.pharep.2014.09.006
10.1074/jbc.M202191200
10.1095/biolreprod57.6.1267
10.1007/978-3-319-55330-6_9
10.1016/j.yjmcc.2014.08.018
10.1016/S0021-9258(19)85172-4
10.1016/j.fertnstert.2009.10.046
10.1016/j.jpedsurg.2007.12.063
10.1016/j.ceca.2013.12.002
10.1016/j.juro.2010.03.109
10.1095/biolreprod63.5.1465
10.1006/cyto.1996.0053
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Keywords Germ cell
Cyclosporine A
Mitochondrial permeability transition pore
Testicular T/D
Apoptosis
Language English
License Published by Elsevier Inc.
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References Bozlu, Acar, Cayan (bb0035) 2009; 27
Turner, Bang, Lysiak (bb0240) 2005; 65
Amaike, Matsumoto, Oka (bb0015) 1996; 8
Sharov, Todor, Khanal (bb0215) 2007; 42
Kurcer, Hekimoglu, Aral (bb0130) 2010; 93
Sullivan, Rabchevsky, Hicks (bb0220) 2000; 101
Zhao, Ji, PH (bb0260) 2013; 38
Ghasemnejad-berenji, Ghazi-Khansari, Yazdani (bb0085) 2017
Motaghinejad, Karimian, Motaghinejad (bb0160) 2015; 67
Yazdani, Ghazi-Khansari, Saeedi Saravi (bb0250) 2017; 49
Jeong, Choi, Chung (bb0115) 2010; 184
Mogilner, Lurie, Coran, Nativ (bb0150) 2006; 22
Aebi (bb0005) 1984; 105
Paoletti, Mocali (bb0190) 1990; 186
Chen, Chien, Yu (bb0045) 2002; 137
Namura, Zhu, Fink (bb0165) 1998; 18
Paglia, Valentine (bb0185) 1967; 70
Javadov, Karmazyn, Escobales (bb0110) 2009; 330
Alavian, K. N., G Beutner, G.,Lazrove, E., et al., 2014. An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Prod. Natl. Acad. Sci. 111, 10580–10585.
Bonora, Bononi, De Marchi (bb0030) 2013; 12
Sakkas, Alvarez (bb0210) 2010; 93
Batiuk, Pazderka, Enns (bb0025) 1995; 96
Clarke, Mc Stay, Halestrap (bb0050) 2002; 277
Ghasemnejad-berenji, Ghazi-Khansari, Yazdani (bb0080) 2017; vol. 20
Azarashvili, Odinokova, A Bakunts (bb0020) 2014; 55
Turner, Bang, Lysiak (bb0235) 2004; 172
Yokoi, Uthus, Nielsen (bb0255) 2003; 93
Payabvash, Kiumehr, Tavangar (bb0200) 2008; 43
Leshnower, Kanemoto, Matsubara (bb0135) 2008; 86
Morciano, Bonora, Campo (bb0155) 2017; 982
Pastorino, Snyder, Serroni (bb0195) 1993; 268
Norman, Canter, Shi (bb0175) 2010; 10
Lysiak, Turner, Nguyen (bb0145) 2001; 65
Di Lisa, Menabò, Canton (bb0070) 2001; 276
Nezami, Rahimpour, Gholipour (bb0170) 2009; 41
Ohkawa, Ohishi, Yagi (bb0180) 1979; 95
Cosentino, Nishida, Rabinowitz (bb0055) 1986; 7
Ho, Clipstone, Timmermann (bb0105) 1996; 80
Kinnally, Peixoto, Ryu (bb0120) 2011; 1813
Wu, Li, Shu (bb0245) 2015; 19
Trounce, Kim, Jun (bb2000) 1996; 264
Friberg, Wieloch (bb0075) 2002; 84
Sun, Luan, Dong (bb0225) 2012; 1436
Lysiak, Turner, Turner (bb0140) 2000; 63
Penzo, Petronilli, Angelin (bb0205) 2004; 279
Turner, Tung, Tomomasa (bb0230) 1997; 57
Crompton, Barksby, Johnson (bb0065) 2002; 84
Halestrap, Richardson (bb0095) 2015; 78
Brockemeier, Carpenter-Deyo, Reed (bb0040) 1992; 304
Crompton (bb0060) 1999; 341
Ghasemnejad-berenji, Ghazi-Khansari, Pashapour (bb0090) 2018; 105
Wu (10.1016/j.yexmp.2019.104271_bb0245) 2015; 19
Turner (10.1016/j.yexmp.2019.104271_bb0230) 1997; 57
Paglia (10.1016/j.yexmp.2019.104271_bb0185) 1967; 70
Ghasemnejad-berenji (10.1016/j.yexmp.2019.104271_bb0085) 2017
Lysiak (10.1016/j.yexmp.2019.104271_bb0145) 2001; 65
Batiuk (10.1016/j.yexmp.2019.104271_bb0025) 1995; 96
Kurcer (10.1016/j.yexmp.2019.104271_bb0130) 2010; 93
Ohkawa (10.1016/j.yexmp.2019.104271_bb0180) 1979; 95
Sullivan (10.1016/j.yexmp.2019.104271_bb0220) 2000; 101
Sakkas (10.1016/j.yexmp.2019.104271_bb0210) 2010; 93
Jeong (10.1016/j.yexmp.2019.104271_bb0115) 2010; 184
Kinnally (10.1016/j.yexmp.2019.104271_bb0120) 2011; 1813
Turner (10.1016/j.yexmp.2019.104271_bb0240) 2005; 65
Cosentino (10.1016/j.yexmp.2019.104271_bb0055) 1986; 7
Turner (10.1016/j.yexmp.2019.104271_bb0235) 2004; 172
Motaghinejad (10.1016/j.yexmp.2019.104271_bb0160) 2015; 67
Sharov (10.1016/j.yexmp.2019.104271_bb0215) 2007; 42
Brockemeier (10.1016/j.yexmp.2019.104271_bb0040) 1992; 304
Pastorino (10.1016/j.yexmp.2019.104271_bb0195) 1993; 268
Crompton (10.1016/j.yexmp.2019.104271_bb0060) 1999; 341
Yokoi (10.1016/j.yexmp.2019.104271_bb0255) 2003; 93
Zhao (10.1016/j.yexmp.2019.104271_bb0260) 2013; 38
Halestrap (10.1016/j.yexmp.2019.104271_bb0095) 2015; 78
Norman (10.1016/j.yexmp.2019.104271_bb0175) 2010; 10
Azarashvili (10.1016/j.yexmp.2019.104271_bb0020) 2014; 55
Leshnower (10.1016/j.yexmp.2019.104271_bb0135) 2008; 86
Clarke (10.1016/j.yexmp.2019.104271_bb0050) 2002; 277
Nezami (10.1016/j.yexmp.2019.104271_bb0170) 2009; 41
Trounce (10.1016/j.yexmp.2019.104271_bb2000) 1996; 264
Namura (10.1016/j.yexmp.2019.104271_bb0165) 1998; 18
10.1016/j.yexmp.2019.104271_bb0010
Crompton (10.1016/j.yexmp.2019.104271_bb0065) 2002; 84
Bozlu (10.1016/j.yexmp.2019.104271_bb0035) 2009; 27
Mogilner (10.1016/j.yexmp.2019.104271_bb0150) 2006; 22
Payabvash (10.1016/j.yexmp.2019.104271_bb0200) 2008; 43
Lysiak (10.1016/j.yexmp.2019.104271_bb0140) 2000; 63
Ho (10.1016/j.yexmp.2019.104271_bb0105) 1996; 80
Yazdani (10.1016/j.yexmp.2019.104271_bb0250) 2017; 49
Ghasemnejad-berenji (10.1016/j.yexmp.2019.104271_bb0090) 2018; 105
Sun (10.1016/j.yexmp.2019.104271_bb0225) 2012; 1436
Amaike (10.1016/j.yexmp.2019.104271_bb0015) 1996; 8
Ghasemnejad-berenji (10.1016/j.yexmp.2019.104271_bb0080) 2017; vol. 20
Morciano (10.1016/j.yexmp.2019.104271_bb0155) 2017; 982
Friberg (10.1016/j.yexmp.2019.104271_bb0075) 2002; 84
Bonora (10.1016/j.yexmp.2019.104271_bb0030) 2013; 12
Chen (10.1016/j.yexmp.2019.104271_bb0045) 2002; 137
Javadov (10.1016/j.yexmp.2019.104271_bb0110) 2009; 330
Aebi (10.1016/j.yexmp.2019.104271_bb0005) 1984; 105
Paoletti (10.1016/j.yexmp.2019.104271_bb0190) 1990; 186
Di Lisa (10.1016/j.yexmp.2019.104271_bb0070) 2001; 276
Penzo (10.1016/j.yexmp.2019.104271_bb0205) 2004; 279
References_xml – volume: 105
  start-page: 121
  year: 1984
  end-page: 126
  ident: bb0005
  article-title: Catalase in vitro
  publication-title: Methods Enzymol.
  contributor:
    fullname: Aebi
– volume: 279
  start-page: 25219
  year: 2004
  end-page: 25225
  ident: bb0205
  article-title: Arachidonic acid released by phospholipase A2 activation triggers Ca2+-dependent apoptosis through the mitochondrial pathway
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Angelin
– volume: 268
  start-page: 13791
  year: 1993
  end-page: 13798
  ident: bb0195
  article-title: Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Serroni
– volume: 172
  start-page: 2574
  year: 2004
  end-page: 2578
  ident: bb0235
  article-title: The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair
  publication-title: J. Urol.
  contributor:
    fullname: Lysiak
– volume: 276
  start-page: 2571
  year: 2001
  end-page: 2575
  ident: bb0070
  article-title: Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Canton
– volume: 65
  start-page: 718
  year: 2001
  end-page: 725
  ident: bb0145
  article-title: Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis
  publication-title: Biol. Reprod.
  contributor:
    fullname: Nguyen
– volume: 22
  start-page: 99
  year: 2006
  end-page: 105
  ident: bb0150
  article-title: Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat
  publication-title: Pediatr. Surg. Int.
  contributor:
    fullname: Nativ
– volume: 80
  start-page: S40
  year: 1996
  end-page: S45
  ident: bb0105
  article-title: The mechanism of action of cyclosporin A and FK506
  publication-title: Clin. Immunol. Immunopathol.
  contributor:
    fullname: Timmermann
– volume: 1436
  start-page: 101
  year: 2012
  end-page: 110
  ident: bb0225
  article-title: Inhibition of mitochondrial permeability transition pore opening contributes to the neuroprotective effects of ischemic postconditioning in rats
  publication-title: Brain Res.
  contributor:
    fullname: Dong
– volume: 43
  start-page: 705
  year: 2008
  end-page: 712
  ident: bb0200
  article-title: Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion
  publication-title: J. Pediatr. Surg.
  contributor:
    fullname: Tavangar
– volume: 93
  start-page: 1027
  year: 2010
  end-page: 1036
  ident: bb0210
  article-title: Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis
  publication-title: Fertil. Steril.
  contributor:
    fullname: Alvarez
– volume: 19
  start-page: 446
  year: 2015
  end-page: 454
  ident: bb0245
  article-title: Blocking the mitochondrial permeability transition pore with cyclosporine-A can restore cardioprotection of ischemic postconditioning in hypercholesterolemic rat heart
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  contributor:
    fullname: Shu
– volume: 264
  start-page: 484
  year: 1996
  end-page: 509
  ident: bb2000
  article-title: [42] Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
  publication-title: Methods Enzymol.
  contributor:
    fullname: Jun
– volume: 8
  start-page: 387
  year: 1996
  end-page: 394
  ident: bb0015
  article-title: Preventive effect of hepatocyte growth factor on acute side effects of cyclosporin A in mice
  publication-title: Cytokine.
  contributor:
    fullname: Oka
– volume: 10
  start-page: 94
  year: 2010
  end-page: 101
  ident: bb0175
  article-title: Cyclosporine A suppresses keratinocyte cell death through mPTP inhibition in a model for skin cancer in organ transplant recipients
  publication-title: Mitochondrion.
  contributor:
    fullname: Shi
– volume: 1813
  start-page: 616
  year: 2011
  end-page: 622
  ident: bb0120
  article-title: Is mPTP the gatekeeper for necrosis, apoptosis, or both?
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Ryu
– volume: 86
  start-page: 1286
  year: 2008
  end-page: 1292
  ident: bb0135
  article-title: Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition
  publication-title: Ann. Thorac. Surg.
  contributor:
    fullname: Matsubara
– volume: 18
  start-page: 3659
  year: 1998
  end-page: 3668
  ident: bb0165
  article-title: Activation and cleavage of Caspase-3 in apoptosis induced by experimental cerebral ischemia
  publication-title: J. Neurosci.
  contributor:
    fullname: Fink
– volume: 277
  start-page: 34793
  year: 2002
  end-page: 34799
  ident: bb0050
  article-title: Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Halestrap
– volume: 49
  start-page: 1
  year: 2017
  end-page: 8
  ident: bb0250
  article-title: Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion
  publication-title: Androl.
  contributor:
    fullname: Saeedi Saravi
– volume: 78
  start-page: 129
  year: 2015
  end-page: 141
  ident: bb0095
  article-title: The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury
  publication-title: J. Mol. Cell. Cardiol.
  contributor:
    fullname: Richardson
– volume: 93
  start-page: 141
  year: 2003
  end-page: 154
  ident: bb0255
  article-title: Nickel deficiency diminishes sperm quantity and movement in rats
  publication-title: Biol. Trace Elem. Res.
  contributor:
    fullname: Nielsen
– volume: 42
  start-page: 150
  year: 2007
  end-page: 158
  ident: bb0215
  article-title: Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure
  publication-title: J. Mol. Cell. Cardiol.
  contributor:
    fullname: Khanal
– volume: 57
  start-page: 1267
  year: 1997
  end-page: 1274
  ident: bb0230
  article-title: Acute testicular ischemia results in germ cell-specific apoptosis in the rat
  publication-title: Biol. Reprod.
  contributor:
    fullname: Tomomasa
– volume: 12
  start-page: 674
  year: 2013
  end-page: 683
  ident: bb0030
  article-title: Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition
  publication-title: Cell Cycle
  contributor:
    fullname: De Marchi
– volume: 70
  start-page: 158
  year: 1967
  end-page: 169
  ident: bb0185
  article-title: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
  publication-title: J. Lab. Clin. Med.
  contributor:
    fullname: Valentine
– volume: 330
  start-page: 670
  year: 2009
  end-page: 678
  ident: bb0110
  article-title: Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Escobales
– volume: 184
  start-page: 790
  year: 2010
  end-page: 796
  ident: bb0115
  article-title: Preventive effects of cyclosporine a combined with prednisolone and melatonin on contralateral testicular damage after ipsilateral torsion-detorsion in pubertal and adult rats
  publication-title: J. Urol.
  contributor:
    fullname: Chung
– volume: 38
  start-page: 705
  year: 2013
  end-page: 713
  ident: bb0260
  article-title: Oxygen glucose deprivation (OGD)/re-oxygenation-induced in vitro neuronal cell death involves mitochondrial cyclophilin-D/P53 signaling axis
  publication-title: Neurochem. Res.
  contributor:
    fullname: PH
– volume: 67
  start-page: 230
  year: 2015
  end-page: 235
  ident: bb0160
  article-title: Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus
  publication-title: Pharmacol. Rep.
  contributor:
    fullname: Motaghinejad
– volume: 7
  start-page: 23
  year: 1986
  end-page: 31
  ident: bb0055
  article-title: Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion
  publication-title: J. Androl.
  contributor:
    fullname: Rabinowitz
– volume: 982
  start-page: 169
  year: 2017
  end-page: 189
  ident: bb0155
  article-title: Mechanistic role of mPTP in ischemia-reperfusion injury
  publication-title: Mitochond. Dyn. Cardiovas. Med.
  contributor:
    fullname: Campo
– volume: vol. 20
  start-page: 905
  year: 2017
  end-page: 911
  ident: bb0080
  article-title: Rapamycin Protects Testes against Germ Cell Apoptosis and Oxidative Stress Induced by Testicular Ischemia-Reperfusion
  contributor:
    fullname: Yazdani
– volume: 341
  start-page: 233
  year: 1999
  end-page: 249
  ident: bb0060
  article-title: The mitochondrial permeability transition pore and its role in cell death
  publication-title: Biochem. J.
  contributor:
    fullname: Crompton
– volume: 93
  start-page: 1545
  year: 2010
  end-page: 1549
  ident: bb0130
  article-title: Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats
  publication-title: Fertil. Steril.
  contributor:
    fullname: Aral
– volume: 41
  start-page: 93
  year: 2009
  end-page: 99
  ident: bb0170
  article-title: Protective effects of immunophilin ligands on testicular torsion/detorsion damage in rats
  publication-title: Int. Urol. Nephrol.
  contributor:
    fullname: Gholipour
– volume: 304
  start-page: 192
  year: 1992
  end-page: 194
  ident: bb0040
  article-title: Cyclosporin A protects hepatocytes subjected to high Ca 2+ and oxidative stress
  publication-title: FEBS Lett.
  contributor:
    fullname: Reed
– volume: 84
  start-page: 143
  year: 2002
  end-page: 152
  ident: bb0065
  article-title: Mitochondrial intermembrane junctional complexes and their involvement in cell death
  publication-title: Biochimie.
  contributor:
    fullname: Johnson
– volume: 55
  start-page: 69
  year: 2014
  end-page: 77
  ident: bb0020
  article-title: Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening
  publication-title: Cell Calcium
  contributor:
    fullname: A Bakunts
– volume: 137
  start-page: 771
  year: 2002
  end-page: 781
  ident: bb0045
  article-title: Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Yu
– volume: 65
  start-page: 390
  year: 2005
  end-page: 394
  ident: bb0240
  article-title: Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations
  publication-title: Urol.
  contributor:
    fullname: Lysiak
– volume: 101
  start-page: 289
  year: 2000
  end-page: 295
  ident: bb0220
  article-title: Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats
  publication-title: Neurosci.
  contributor:
    fullname: Hicks
– volume: 96
  start-page: 1254
  year: 1995
  ident: bb0025
  article-title: Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Enns
– volume: 95
  start-page: 351
  year: 1979
  end-page: 358
  ident: bb0180
  article-title: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
  publication-title: Anal. Biochem.
  contributor:
    fullname: Yagi
– volume: 84
  start-page: 241
  year: 2002
  end-page: 250
  ident: bb0075
  article-title: Mitochondrial permeability transition in acute neurodegeneration
  publication-title: Biochimie
  contributor:
    fullname: Wieloch
– volume: 63
  start-page: 1465
  year: 2000
  end-page: 1472
  ident: bb0140
  article-title: Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
  publication-title: Biol. Reprod.
  contributor:
    fullname: Turner
– volume: 186
  start-page: 209
  year: 1990
  end-page: 220
  ident: bb0190
  article-title: Determination of superoxide dismutase activity by purely chemical system based on NAD (P) H oOxidation
  publication-title: Methods Enzymol.
  contributor:
    fullname: Mocali
– year: 2017
  ident: bb0085
  article-title: Effect of Metformin on Germ Cell-Specific Apoptosis, Oxidative Stress and Epididymal Sperm Quality after Testicular Torsion/Detorsion in Rats. Androl
  contributor:
    fullname: Yazdani
– volume: 105
  start-page: 645
  year: 2018
  end-page: 651
  ident: bb0090
  article-title: Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats
  publication-title: Biomed. Pharmacother.
  contributor:
    fullname: Pashapour
– volume: 27
  start-page: 117
  year: 2009
  end-page: 122
  ident: bb0035
  article-title: Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury
  publication-title: World J. Urol.
  contributor:
    fullname: Cayan
– volume: 96
  start-page: 1254
  year: 1995
  ident: 10.1016/j.yexmp.2019.104271_bb0025
  article-title: Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI118159
  contributor:
    fullname: Batiuk
– volume: vol. 20
  start-page: 905
  year: 2017
  ident: 10.1016/j.yexmp.2019.104271_bb0080
  contributor:
    fullname: Ghasemnejad-berenji
– volume: 41
  start-page: 93
  year: 2009
  ident: 10.1016/j.yexmp.2019.104271_bb0170
  article-title: Protective effects of immunophilin ligands on testicular torsion/detorsion damage in rats
  publication-title: Int. Urol. Nephrol.
  doi: 10.1007/s11255-008-9453-5
  contributor:
    fullname: Nezami
– volume: 276
  start-page: 2571
  year: 2001
  ident: 10.1016/j.yexmp.2019.104271_bb0070
  article-title: Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M006825200
  contributor:
    fullname: Di Lisa
– volume: 105
  start-page: 121
  year: 1984
  ident: 10.1016/j.yexmp.2019.104271_bb0005
  article-title: Catalase in vitro
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(84)05016-3
  contributor:
    fullname: Aebi
– volume: 172
  start-page: 2574
  year: 2004
  ident: 10.1016/j.yexmp.2019.104271_bb0235
  article-title: The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair
  publication-title: J. Urol.
  doi: 10.1097/01.ju.0000144203.30718.19
  contributor:
    fullname: Turner
– volume: 304
  start-page: 192
  year: 1992
  ident: 10.1016/j.yexmp.2019.104271_bb0040
  article-title: Cyclosporin A protects hepatocytes subjected to high Ca 2+ and oxidative stress
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(92)80616-O
  contributor:
    fullname: Brockemeier
– volume: 330
  start-page: 670
  year: 2009
  ident: 10.1016/j.yexmp.2019.104271_bb0110
  article-title: Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.109.153213
  contributor:
    fullname: Javadov
– volume: 1436
  start-page: 101
  year: 2012
  ident: 10.1016/j.yexmp.2019.104271_bb0225
  article-title: Inhibition of mitochondrial permeability transition pore opening contributes to the neuroprotective effects of ischemic postconditioning in rats
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2011.11.055
  contributor:
    fullname: Sun
– year: 2017
  ident: 10.1016/j.yexmp.2019.104271_bb0085
  contributor:
    fullname: Ghasemnejad-berenji
– volume: 84
  start-page: 143
  year: 2002
  ident: 10.1016/j.yexmp.2019.104271_bb0065
  article-title: Mitochondrial intermembrane junctional complexes and their involvement in cell death
  publication-title: Biochimie.
  doi: 10.1016/S0300-9084(02)01368-8
  contributor:
    fullname: Crompton
– volume: 19
  start-page: 446
  year: 2015
  ident: 10.1016/j.yexmp.2019.104271_bb0245
  article-title: Blocking the mitochondrial permeability transition pore with cyclosporine-A can restore cardioprotection of ischemic postconditioning in hypercholesterolemic rat heart
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  contributor:
    fullname: Wu
– volume: 38
  start-page: 705
  year: 2013
  ident: 10.1016/j.yexmp.2019.104271_bb0260
  article-title: Oxygen glucose deprivation (OGD)/re-oxygenation-induced in vitro neuronal cell death involves mitochondrial cyclophilin-D/P53 signaling axis
  publication-title: Neurochem. Res.
  doi: 10.1007/s11064-013-0968-5
  contributor:
    fullname: Zhao
– volume: 10
  start-page: 94
  year: 2010
  ident: 10.1016/j.yexmp.2019.104271_bb0175
  article-title: Cyclosporine A suppresses keratinocyte cell death through mPTP inhibition in a model for skin cancer in organ transplant recipients
  publication-title: Mitochondrion.
  doi: 10.1016/j.mito.2009.10.001
  contributor:
    fullname: Norman
– volume: 95
  start-page: 351
  year: 1979
  ident: 10.1016/j.yexmp.2019.104271_bb0180
  article-title: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(79)90738-3
  contributor:
    fullname: Ohkawa
– volume: 186
  start-page: 209
  year: 1990
  ident: 10.1016/j.yexmp.2019.104271_bb0190
  article-title: Determination of superoxide dismutase activity by purely chemical system based on NAD (P) H oOxidation
  publication-title: Methods Enzymol.
  doi: 10.1016/0076-6879(90)86110-H
  contributor:
    fullname: Paoletti
– volume: 264
  start-page: 484
  year: 1996
  ident: 10.1016/j.yexmp.2019.104271_bb2000
  article-title: [42] Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(96)64044-0
  contributor:
    fullname: Trounce
– volume: 49
  start-page: 1
  year: 2017
  ident: 10.1016/j.yexmp.2019.104271_bb0250
  article-title: Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion
  publication-title: Androl.
  doi: 10.1111/and.12605
  contributor:
    fullname: Yazdani
– volume: 42
  start-page: 150
  year: 2007
  ident: 10.1016/j.yexmp.2019.104271_bb0215
  article-title: Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2006.09.013
  contributor:
    fullname: Sharov
– volume: 84
  start-page: 241
  year: 2002
  ident: 10.1016/j.yexmp.2019.104271_bb0075
  article-title: Mitochondrial permeability transition in acute neurodegeneration
  publication-title: Biochimie
  doi: 10.1016/S0300-9084(02)01381-0
  contributor:
    fullname: Friberg
– volume: 22
  start-page: 99
  year: 2006
  ident: 10.1016/j.yexmp.2019.104271_bb0150
  article-title: Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat
  publication-title: Pediatr. Surg. Int.
  doi: 10.1007/s00383-005-1580-9
  contributor:
    fullname: Mogilner
– ident: 10.1016/j.yexmp.2019.104271_bb0010
  doi: 10.1073/pnas.1401591111
– volume: 65
  start-page: 718
  year: 2001
  ident: 10.1016/j.yexmp.2019.104271_bb0145
  article-title: Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod65.3.718
  contributor:
    fullname: Lysiak
– volume: 70
  start-page: 158
  year: 1967
  ident: 10.1016/j.yexmp.2019.104271_bb0185
  article-title: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
  publication-title: J. Lab. Clin. Med.
  contributor:
    fullname: Paglia
– volume: 137
  start-page: 771
  year: 2002
  ident: 10.1016/j.yexmp.2019.104271_bb0045
  article-title: Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0704908
  contributor:
    fullname: Chen
– volume: 341
  start-page: 233
  issue: Pt 2
  year: 1999
  ident: 10.1016/j.yexmp.2019.104271_bb0060
  article-title: The mitochondrial permeability transition pore and its role in cell death
  publication-title: Biochem. J.
  doi: 10.1042/bj3410233
  contributor:
    fullname: Crompton
– volume: 7
  start-page: 23
  year: 1986
  ident: 10.1016/j.yexmp.2019.104271_bb0055
  article-title: Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion
  publication-title: J. Androl.
  doi: 10.1002/j.1939-4640.1986.tb00862.x
  contributor:
    fullname: Cosentino
– volume: 105
  start-page: 645
  year: 2018
  ident: 10.1016/j.yexmp.2019.104271_bb0090
  article-title: Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2018.06.012
  contributor:
    fullname: Ghasemnejad-berenji
– volume: 86
  start-page: 1286
  year: 2008
  ident: 10.1016/j.yexmp.2019.104271_bb0135
  article-title: Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition
  publication-title: Ann. Thorac. Surg.
  doi: 10.1016/j.athoracsur.2008.06.033
  contributor:
    fullname: Leshnower
– volume: 93
  start-page: 1545
  year: 2010
  ident: 10.1016/j.yexmp.2019.104271_bb0130
  article-title: Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2009.01.146
  contributor:
    fullname: Kurcer
– volume: 1813
  start-page: 616
  year: 2011
  ident: 10.1016/j.yexmp.2019.104271_bb0120
  article-title: Is mPTP the gatekeeper for necrosis, apoptosis, or both?
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2010.09.013
  contributor:
    fullname: Kinnally
– volume: 101
  start-page: 289
  year: 2000
  ident: 10.1016/j.yexmp.2019.104271_bb0220
  article-title: Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats
  publication-title: Neurosci.
  doi: 10.1016/S0306-4522(00)00380-8
  contributor:
    fullname: Sullivan
– volume: 27
  start-page: 117
  year: 2009
  ident: 10.1016/j.yexmp.2019.104271_bb0035
  article-title: Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury
  publication-title: World J. Urol.
  doi: 10.1007/s00345-008-0323-7
  contributor:
    fullname: Bozlu
– volume: 80
  start-page: S40
  year: 1996
  ident: 10.1016/j.yexmp.2019.104271_bb0105
  article-title: The mechanism of action of cyclosporin A and FK506
  publication-title: Clin. Immunol. Immunopathol.
  doi: 10.1006/clin.1996.0140
  contributor:
    fullname: Ho
– volume: 12
  start-page: 674
  year: 2013
  ident: 10.1016/j.yexmp.2019.104271_bb0030
  article-title: Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition
  publication-title: Cell Cycle
  doi: 10.4161/cc.23599
  contributor:
    fullname: Bonora
– volume: 18
  start-page: 3659
  year: 1998
  ident: 10.1016/j.yexmp.2019.104271_bb0165
  article-title: Activation and cleavage of Caspase-3 in apoptosis induced by experimental cerebral ischemia
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-10-03659.1998
  contributor:
    fullname: Namura
– volume: 65
  start-page: 390
  year: 2005
  ident: 10.1016/j.yexmp.2019.104271_bb0240
  article-title: Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations
  publication-title: Urol.
  doi: 10.1016/j.urology.2004.09.033
  contributor:
    fullname: Turner
– volume: 93
  start-page: 141
  year: 2003
  ident: 10.1016/j.yexmp.2019.104271_bb0255
  article-title: Nickel deficiency diminishes sperm quantity and movement in rats
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1385/BTER:93:1-3:141
  contributor:
    fullname: Yokoi
– volume: 279
  start-page: 25219
  year: 2004
  ident: 10.1016/j.yexmp.2019.104271_bb0205
  article-title: Arachidonic acid released by phospholipase A2 activation triggers Ca2+-dependent apoptosis through the mitochondrial pathway
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M310381200
  contributor:
    fullname: Penzo
– volume: 67
  start-page: 230
  year: 2015
  ident: 10.1016/j.yexmp.2019.104271_bb0160
  article-title: Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus
  publication-title: Pharmacol. Rep.
  doi: 10.1016/j.pharep.2014.09.006
  contributor:
    fullname: Motaghinejad
– volume: 277
  start-page: 34793
  year: 2002
  ident: 10.1016/j.yexmp.2019.104271_bb0050
  article-title: Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M202191200
  contributor:
    fullname: Clarke
– volume: 57
  start-page: 1267
  year: 1997
  ident: 10.1016/j.yexmp.2019.104271_bb0230
  article-title: Acute testicular ischemia results in germ cell-specific apoptosis in the rat
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod57.6.1267
  contributor:
    fullname: Turner
– volume: 982
  start-page: 169
  year: 2017
  ident: 10.1016/j.yexmp.2019.104271_bb0155
  article-title: Mechanistic role of mPTP in ischemia-reperfusion injury
  publication-title: Mitochond. Dyn. Cardiovas. Med.
  doi: 10.1007/978-3-319-55330-6_9
  contributor:
    fullname: Morciano
– volume: 78
  start-page: 129
  year: 2015
  ident: 10.1016/j.yexmp.2019.104271_bb0095
  article-title: The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2014.08.018
  contributor:
    fullname: Halestrap
– volume: 268
  start-page: 13791
  year: 1993
  ident: 10.1016/j.yexmp.2019.104271_bb0195
  article-title: Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)85172-4
  contributor:
    fullname: Pastorino
– volume: 93
  start-page: 1027
  year: 2010
  ident: 10.1016/j.yexmp.2019.104271_bb0210
  article-title: Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2009.10.046
  contributor:
    fullname: Sakkas
– volume: 43
  start-page: 705
  year: 2008
  ident: 10.1016/j.yexmp.2019.104271_bb0200
  article-title: Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion
  publication-title: J. Pediatr. Surg.
  doi: 10.1016/j.jpedsurg.2007.12.063
  contributor:
    fullname: Payabvash
– volume: 55
  start-page: 69
  year: 2014
  ident: 10.1016/j.yexmp.2019.104271_bb0020
  article-title: Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2013.12.002
  contributor:
    fullname: Azarashvili
– volume: 184
  start-page: 790
  year: 2010
  ident: 10.1016/j.yexmp.2019.104271_bb0115
  article-title: Preventive effects of cyclosporine a combined with prednisolone and melatonin on contralateral testicular damage after ipsilateral torsion-detorsion in pubertal and adult rats
  publication-title: J. Urol.
  doi: 10.1016/j.juro.2010.03.109
  contributor:
    fullname: Jeong
– volume: 63
  start-page: 1465
  year: 2000
  ident: 10.1016/j.yexmp.2019.104271_bb0140
  article-title: Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod63.5.1465
  contributor:
    fullname: Lysiak
– volume: 8
  start-page: 387
  year: 1996
  ident: 10.1016/j.yexmp.2019.104271_bb0015
  article-title: Preventive effect of hepatocyte growth factor on acute side effects of cyclosporin A in mice
  publication-title: Cytokine.
  doi: 10.1006/cyto.1996.0053
  contributor:
    fullname: Amaike
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Snippet Testicular torsion/detorsion (T/D) is an inflammatory problem in men genital system with infertility effects. Cyclosporine A (CsA) as an immunosuppressant...
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StartPage 104271
SubjectTerms Animals
Apoptosis
Apoptosis - drug effects
Caspase 3 - metabolism
Catalase - metabolism
Cyclosporine - pharmacology
Cyclosporine A
Epididymis - drug effects
Epididymis - metabolism
Epididymis - pathology
Germ cell
Germ Cells
Glutathione Peroxidase - metabolism
Immunosuppressive Agents - pharmacology
Male
Malondialdehyde - metabolism
Mitochondrial permeability transition pore
Oxidative Stress - drug effects
Rats, Wistar
Reperfusion Injury - physiopathology
Spermatic Cord Torsion - physiopathology
Spermatozoa - drug effects
Spermatozoa - pathology
Superoxide Dismutase - metabolism
Testicular T/D
Testis - blood supply
Testis - drug effects
Testis - metabolism
Title Comparison of multiple doses of cyclosporine A on germ cell apoptosis and epididymal sperm parameters after testicular ischemia/reperfusion in rats
URI https://dx.doi.org/10.1016/j.yexmp.2019.104271
https://www.ncbi.nlm.nih.gov/pubmed/31251898
Volume 110
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