Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles

• Published in: Scientific reports Vol. 6; no. 1; p. 21683
• Main Authors: Zhu, Xu, Guo, Jun, He, Cancan, Geng, Huaxiao, Yu, Gengsheng, Li, Jinqing, Zheng, Hairong, Ji, Xiaojuan, Yan, Fei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2016; Nature Publishing Group
• Subjects: 631/154/152; 692/308/153; Animals; Antineoplastic Agents, Phytogenic - pharmacology; Constriction, Pathologic - pathology; Constriction, Pathologic - therapy; Drug Compounding; Drug delivery; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Humanities and Social Sciences; Hydration; Hyperplasia; Iliac Artery - drug effects; Iliac Artery - pathology; Intravenous administration; Kidneys; Liver; Microbubbles; multidisciplinary; Muscle, Smooth, Vascular - radiation effects; Myocytes, Smooth Muscle - radiation effects; Paclitaxel; Paclitaxel - pharmacology; Rabbits; Radiation; Restenosis; Science; Smooth muscle; Stents; Therapeutic applications; Ultrasonic imaging; Ultrasonic Waves; Ultrasound

Paclitaxel (PTX) has been recognized as a promising drug for intervention of vascular reconstructions. However, it is still difficult to achieve local drug delivery in a spatio-temporally controllable manner under real-time image guidance. Here, we introduce an ultrasound (US) triggered image-guided...