Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations

• Published in: Immunologic research Vol. 73; no. 1; p. 11
• Main Authors: Sant’Ana, Alexia N., Dias, Camila K., Nunes, Vitória B. S., Farias, Mariela G., Alegretti, Ana P., Portela, Pâmela, Calvache, Ebellins T., Meirelles, Maria F., Daudt, Liane E., Michalowski, Mariana B., Paz, Alessandra A., Figueiró, Fabrício
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2025; Springer Nature B.V
• Subjects: Acute myeloid leukemia; Adaptive immunity; Adult; Aged; Aged, 80 and over; Allergology; Antigens, CD - metabolism; Biomedical and Life Sciences; Biomedicine; CD11b antigen; CD13 antigen; CD36 antigen; CD45 antigen; Cell survival; Female; Flow Cytometry; fms-Like Tyrosine Kinase 3 - genetics; fms-Like Tyrosine Kinase 3 - metabolism; Humans; Immunology; Immunophenotyping; Internal Medicine; Leukemia; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - immunology; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; Leukocytes (neutrophilic); Lymphocytes T; Male; Maturation; Medical prognosis; Medicine/Public Health; Middle Aged; Monocytes; Mutation; myeloid leukemia; Myeloid-Derived Suppressor Cells - immunology; neoplasm progression; neutrophils; Neutrophils - immunology; Prognosis; Retrospective Studies; Suppressor cells; T-Lymphocytes - immunology; Young Adult; PMN-MDSCs; Prognosis; M-MDSCs; Acute myeloid leukemia; Neutrophil maturation stages

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that acts on both innate and adaptive immunity, fostering immune escape in tumors and contributing to cancer progression. Despite the lack of definitive markers for immunophenotyping MDSCs, particularly the polymorphonuclear (PM...