LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214

• Published in: Experimental and molecular pathology Vol. 107; pp. 77 - 84
• Main Authors: Wang, Cheng-Gong, Liao, Zhan, Xiao, Han, Liu, Hua, Hu, Yi-He, Liao, Qian-De, Zhong, Da
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.04.2019
• Subjects: BMP2; BMSCs; Bone Morphogenetic Protein 2 - biosynthesis; Cell Differentiation - physiology; Cells, Cultured; Gene Expression Regulation - physiology; Humans; KCNQ1OT1; Mesenchymal Stem Cells - cytology; MicroRNAs - metabolism; MiR-214; Osteogenesis - physiology; Osteogenic differentiation; Potassium Channels, Voltage-Gated - physiology; BMP2; MiR-214; Osteogenic differentiation; KCNQ1OT1; BMSCs

Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is of much significance for bone formation, the imbalance of it would result in osteoporosis and other pathological bone defects. Increasing evidences showed that long non-coding RNAs (lncRNAs) and miRNAs played vital roles in...