RNA interference: a chemist's perspective

• Published in: Chemical Society reviews Vol. 39; no. 11; pp. 4169 - 4184
• Main Authors: Gaynor, James W, Campbell, Barry J, Cosstick, Richard
• Format: Journal Article
• Language: English
• Published: England 19.10.2010
• Subjects: Animals; genes; Humans; Nucleic Acid Conformation; Nucleic Acids - chemical synthesis; Nucleic Acids - chemistry; oligonucleotides; RNA Interference; small interfering RNA

Since the first unequivocal description of RNA interference (RNAi) in 1998, it has remained one of the hottest topics under investigation, culminating in the award of a Nobel Prize to its discoverers in 2006. Excitement over this technique derives from the ease with which it can be used to switch-of...