The estrogen-regulated lncRNA H19/miR-216a-5p axis alters stromal cell invasion and migration via ACTA2 in endometriosis

• Published in: Molecular human reproduction Vol. 25; no. 9; pp. 550 - 561
• Main Authors: Xu, Zhen, Zhang, Liping, Yu, Qian, Zhang, Yanan, Yan, Lei, Chen, Zi-Jiang
• Format: Journal Article
• Language: English
• Published: England 01.09.2019
• Subjects: endometriosis; migration; primary eutopic endometrial stromal cells; fibrosis; lncH19/miR-216a-5p/ACTA2 pathway; invasion

Fibrotic tissue may contribute to the origin of some endometriosis-related symptoms, such as chronic pelvic pain and infertility. Alterations in the H19/miR-216a-5p/ACTA2 pathway may mediate the regulation of eutopic endometrial stromal cell (euESC) invasion and migration and may represent a potenti...