Fibroblast growth factor receptors, developmental corruption and malignant disease

• Published in: Carcinogenesis (New York) Vol. 34; no. 10; pp. 2198 - 2205
• Main Authors: Kelleher, F. C., O'Sullivan, H., Smyth, E., McDermott, R., Viterbo, A.
• Format: Journal Article
• Language: English
• Published: England 01.10.2013
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Humans; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Receptors, Fibroblast Growth Factor - antagonists & inhibitors; Receptors, Fibroblast Growth Factor - genetics; Receptors, Fibroblast Growth Factor - metabolism

Fibroblast growth factors (FGF) are a family of ligands that bind to four different types of cell surface receptor entitled, FGFR1, FGFR2, FGFR3 and FGFR4. These receptors differ in their ligand binding affinity and tissue distribution. The prototypical receptor structure is that of an extracellular...