Urinary cysteinyl progestogens: Occurrence and origin

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 152; pp. 53 - 61
• Main Authors: Marcos, Josep, Pol, Marta, Fabregat, Andreu, Ventura, Rosa, Renau, Nuria, Hanzu, Felicia A., Casals, Gregori, Marfà, Santi, Barceló, Bernardí, Barceló, Antonia, Robles, Juan, Segura, Jordi, Pozo, Oscar J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2015
• Subjects: Adrenal glands; Adrenocorticotropic Hormone - pharmacology; Adult; Cell Line, Tumor; Child; Cysteine - analogs & derivatives; Cysteine - urine; Cysteinyl; Female; Gonads; Hep G2 Cells; Hepatocytes - metabolism; Humans; Hydrocortisone - pharmacology; Liver - metabolism; Luteal Phase; Male; Mass spectrometry; Ovary - metabolism; Placenta; Placenta - metabolism; Pregnancy; Pregnenolone - analogs & derivatives; Pregnenolone - urine; Progesterone - analogs & derivatives; Progesterone - urine; Progestins - urine; Progestogen; Cysteinyl; Placenta; Adrenal glands; Gonads; Mass spectrometry; Progestogen

[Display omitted] •16-Cysteinyl-progesterone and 16-cysteinyl-pregnenolone are excreted in human urine.•Chemically synthesized materials and LC–MS/MS allowed unequivocal identification.•Different experiments point toward an adrenal origin for both novel progestogens.•16-Cysteinyl-progesterone is als...