Elevation of HO-1 expression protects the intestinal mucosal barrier in severe acute pancreatitis via inhibition of the MLCK/p-MLC signaling pathway

• Published in: Experimental cell research Vol. 424; no. 2; p. 113508
• Main Authors: Zhang, Jingyin, Jiang, Yingjian, Li, Hongbo, Wang, Jiang, Li, Chang, Zhang, Dianliang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2023
• Subjects: Acute Disease; Animals; Apoptosis; Heme Oxygenase-1 - metabolism; Hemin - pharmacology; HO-1; Intestinal barrier barrier; Intestinal Mucosa - metabolism; Male; Myosin light chain kinase; Oxidative stress; Pancreatitis - chemically induced; Pancreatitis - drug therapy; Pancreatitis - metabolism; Rats; Rats, Sprague-Dawley; Severe acute pancreatitis; Signal Transduction; Oxidative stress; Intestinal barrier barrier; HO-1; Severe acute pancreatitis; Myosin light chain kinase; Apoptosis

In severe acute pancreatitis (SAP), intestinal mucosal barrier damage can cause intestinal bacterial translocation and induce or aggravate systemic infections. Heme oxygenase-1 (HO-1) is a validated antioxidant and cytoprotective agent. This research aimed to investigate the effect and mechanism of...