Stem cells, pluripotency and glial cell markers in peripheral blood of bipolar patients on long-term lithium treatment

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 80; no. Pt A; pp. 28 - 33
• Main Authors: Ferensztajn-Rochowiak, Ewa, Kucharska-Mazur, Jolanta, Tarnowski, Maciej, Samochowiec, Jerzy, Ratajczak, Mariusz Z., Rybakowski, Janusz K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.01.2018
• Subjects: Adult; Antimanic Agents - pharmacology; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biomarkers - blood; Bipolar disorder; Bipolar Disorder - blood; Bipolar Disorder - drug therapy; Cell Count; Female; Glial cell markers; Glial Fibrillary Acidic Protein - metabolism; Humans; Lithium; Lithium Compounds - pharmacology; Male; Middle Aged; Nanog Homeobox Protein - metabolism; Nerve Tissue Proteins - metabolism; Octamer Transcription Factor-3 - metabolism; Oligodendrocyte Transcription Factor 2 - metabolism; Pluripotency markers; Pluripotent Stem Cells; RNA, Messenger - blood; SOXB1 Transcription Factors - metabolism; Very small embryonic-like stem cells; Glial cell markers; Bipolar disorder; Lithium; Pluripotency markers; Very small embryonic-like stem cells

We investigated the effect of long-term lithium treatment on very-small embryonic-like stem cells (VSELs) and the mRNA expression of pluripotency and glial markers, in peripheral blood, in patients with bipolar disorder (BD). Fifteen BD patients (aged 53±7years) not treated with lithium, with durati...