Kidney biopsies in methotrexate-treated psoriatics

• Published in: Dermatologica Vol. 181; no. 4; p. 273
• Main Authors: Zachariae, H, Hansen, H E, Søgaard, H, Olsen, T S
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1990
• Subjects: Adult; Aged; Biopsy; Female; Fibrosis; Follow-Up Studies; Humans; Kidney - drug effects; Kidney - pathology; Male; Methotrexate - administration & dosage; Methotrexate - therapeutic use; Middle Aged; Psoriasis - drug therapy

Kidney biopsies were studied in 19 psoriatics treated with methotrexate (MTX) from 1 month to 16 years. Only 3 of the patients had received the drug for less than 1 year. Four patients had been treated for more than 10 years. The total doses of MTX ranged from 30 to 14,340 mg. In 17 of the 19 patien...