De Novo Allergy and Immune-Mediated Disorders Following Solid-Organ Transplantation—Prevalence, Natural History, and Risk Factors
To describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity. A cross-sectional, cohort study of all children (<18 years) who underwent a solid-organ transplantation, between 2000 and 2012, in a single transplant center, with a follow-u...
Saved in:
Published in | The Journal of pediatrics Vol. 196; pp. 154 - 160.e2 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.05.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | To describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity.
A cross-sectional, cohort study of all children (<18 years) who underwent a solid-organ transplantation, between 2000 and 2012, in a single transplant center, with a follow-up period of 6 months or more post-transplant and without history of allergy or immune-mediated disorder pretransplant.
A total of 626 eligible patients were screened, and 273 patients (160 males; 59%) met the inclusion criteria; this included 111 liver, 103 heart, 52 kidney, and 7 multivisceral recipients. Patients were followed for a median period of 3.6 years. A total of 92 (34%) patients (42 males, 46%) developed allergy or autoimmune disease after transplantation, with a high prevalence among liver (41%), heart (40%), and multivisceral (57%) transplant recipients compared with kidney recipients (4%; P < .001). Post-transplant allergies included eczema (n = 44), food allergy (22), eosinophilic gastrointestinal disease (11), and asthma (28). Autoimmunity occurred in 18 (6.6%) patients, presenting mainly as autoimmune cytopenia (n = 10). In a multivariate analysis, female sex, young age at transplantation, family history of allergy, Epstein–Barr virus infection, and elevated eosinophil count >6 months post-transplantation were associated with an increased risk for allergy or autoimmunity. Two patients (0.7%) died from autoimmune hemolytic anemia and hemophagocytic lymphohistiocytosis, and 52 episodes of post-transplant allergy, autoimmunity, and immune-mediated disorders (37%) did not improve over time.
Allergy and autoimmunity are common in pediatric liver, heart, and multivisceral transplant recipients and pose a significant health burden. Further studies are required to clarify the mechanisms behind this post-transplant immune dysregulation. |
---|---|
AbstractList | To describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity.
A cross-sectional, cohort study of all children (<18 years) who underwent a solid-organ transplantation, between 2000 and 2012, in a single transplant center, with a follow-up period of 6 months or more post-transplant and without history of allergy or immune-mediated disorder pretransplant.
A total of 626 eligible patients were screened, and 273 patients (160 males; 59%) met the inclusion criteria; this included 111 liver, 103 heart, 52 kidney, and 7 multivisceral recipients. Patients were followed for a median period of 3.6 years. A total of 92 (34%) patients (42 males, 46%) developed allergy or autoimmune disease after transplantation, with a high prevalence among liver (41%), heart (40%), and multivisceral (57%) transplant recipients compared with kidney recipients (4%; P < .001). Post-transplant allergies included eczema (n = 44), food allergy (22), eosinophilic gastrointestinal disease (11), and asthma (28). Autoimmunity occurred in 18 (6.6%) patients, presenting mainly as autoimmune cytopenia (n = 10). In a multivariate analysis, female sex, young age at transplantation, family history of allergy, Epstein-Barr virus infection, and elevated eosinophil count >6 months post-transplantation were associated with an increased risk for allergy or autoimmunity. Two patients (0.7%) died from autoimmune hemolytic anemia and hemophagocytic lymphohistiocytosis, and 52 episodes of post-transplant allergy, autoimmunity, and immune-mediated disorders (37%) did not improve over time.
Allergy and autoimmunity are common in pediatric liver, heart, and multivisceral transplant recipients and pose a significant health burden. Further studies are required to clarify the mechanisms behind this post-transplant immune dysregulation. OBJECTIVESTo describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity.STUDY DESIGNA cross-sectional, cohort study of all children (<18 years) who underwent a solid-organ transplantation, between 2000 and 2012, in a single transplant center, with a follow-up period of 6 months or more post-transplant and without history of allergy or immune-mediated disorder pretransplant.RESULTSA total of 626 eligible patients were screened, and 273 patients (160 males; 59%) met the inclusion criteria; this included 111 liver, 103 heart, 52 kidney, and 7 multivisceral recipients. Patients were followed for a median period of 3.6 years. A total of 92 (34%) patients (42 males, 46%) developed allergy or autoimmune disease after transplantation, with a high prevalence among liver (41%), heart (40%), and multivisceral (57%) transplant recipients compared with kidney recipients (4%; P < .001). Post-transplant allergies included eczema (n = 44), food allergy (22), eosinophilic gastrointestinal disease (11), and asthma (28). Autoimmunity occurred in 18 (6.6%) patients, presenting mainly as autoimmune cytopenia (n = 10). In a multivariate analysis, female sex, young age at transplantation, family history of allergy, Epstein-Barr virus infection, and elevated eosinophil count >6 months post-transplantation were associated with an increased risk for allergy or autoimmunity. Two patients (0.7%) died from autoimmune hemolytic anemia and hemophagocytic lymphohistiocytosis, and 52 episodes of post-transplant allergy, autoimmunity, and immune-mediated disorders (37%) did not improve over time.CONCLUSIONSAllergy and autoimmunity are common in pediatric liver, heart, and multivisceral transplant recipients and pose a significant health burden. Further studies are required to clarify the mechanisms behind this post-transplant immune dysregulation. |
Author | Walters, Thomas Ng, Vicky L. Dipchand, Anne Hebert, Diane Amir, Achiya Z. Marcus, Nufar Grunebaum, Eyal Avitzur, Yaron |
Author_xml | – sequence: 1 givenname: Nufar surname: Marcus fullname: Marcus, Nufar organization: Division of Immunology and Allergy, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 2 givenname: Achiya Z. orcidid: 0000-0002-2231-4209 surname: Amir fullname: Amir, Achiya Z. organization: Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 3 givenname: Eyal surname: Grunebaum fullname: Grunebaum, Eyal organization: Division of Immunology and Allergy, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 4 givenname: Anne surname: Dipchand fullname: Dipchand, Anne organization: Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 5 givenname: Diane surname: Hebert fullname: Hebert, Diane organization: Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 6 givenname: Vicky L. surname: Ng fullname: Ng, Vicky L. organization: Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 7 givenname: Thomas surname: Walters fullname: Walters, Thomas organization: Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 8 givenname: Yaron surname: Avitzur fullname: Avitzur, Yaron email: yaron.avitzur@sickkids.ca organization: Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29395171$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kMFu1DAQhi1URLeFJ0BCPnJogsdOnPWBQ9WytFJpEZSz5Y0nKy-OvdjJor0h8Qo8IU9Ctls4chpp9M38M98JOQoxICEvgZXAQL5Zl-sN2lxyBk0JUDIun5AZMNUUci7EEZkxxnkhqkYek5Oc14wxVTH2jBxzJVQNDczIz0ukt3Eb6bn3mFY7aoKl130_Biw-oHVmQEsvXY7JYsp0Eb2P311Y0c_RO1vcpZUJ9D6ZkDfehMEMLobfP359TLg1HkOLZ_TWDGMynl65PMS0O3uI-OTyV7ow7dTJz8nTzviMLx7rKfmyeHd_cVXc3L2_vji_KVpRq6FQS8bnSkgloavVsmOATd1hY6zEWtW1qFmlqraBtrIVk0vBgRsuDDZMCrQgTsnrw95Nit9GzIPuXW7RT4djHLMGNWlRFZ_vUXFA2xRzTtjpTXK9STsNTO_t67V-sK_39jWAnuxPU68eA8Zlj_bfzF_dE_D2AOD05tZh0rl1e0vWJWwHbaP7b8AfdsqaLg |
CitedBy_id | crossref_primary_10_1016_j_autrev_2018_06_016 crossref_primary_10_1111_pde_15280 crossref_primary_10_1016_j_humimm_2024_110827 crossref_primary_10_1016_j_annder_2024_103259 crossref_primary_10_1097_QCO_0000000000000461 crossref_primary_10_14309_ajg_0000000000000934 crossref_primary_10_1111_petr_13264 crossref_primary_10_1111_petr_14473 crossref_primary_10_1016_j_jpeds_2018_08_050 crossref_primary_10_1111_petr_14252 crossref_primary_10_1111_jpc_16349 crossref_primary_10_1542_peds_2020_0696 crossref_primary_10_1007_s13555_021_00586_w crossref_primary_10_1016_j_clim_2021_108896 crossref_primary_10_3390_hematolrep14030036 crossref_primary_10_1016_j_humimm_2024_110809 crossref_primary_10_1097_MCO_0000000000000901 crossref_primary_10_1097_MPG_0000000000003344 crossref_primary_10_1097_TP_0000000000002751 crossref_primary_10_1111_dth_15324 crossref_primary_10_1016_j_jdcr_2022_03_015 crossref_primary_10_1111_dth_14018 crossref_primary_10_1016_j_trim_2021_101438 crossref_primary_10_1111_petr_14664 crossref_primary_10_1007_s00415_019_09374_1 crossref_primary_10_1111_petr_13399 crossref_primary_10_1016_j_anai_2019_07_025 crossref_primary_10_3389_fimmu_2021_630051 crossref_primary_10_1111_petr_13737 crossref_primary_10_3389_fimmu_2022_817062 crossref_primary_10_1007_s11912_019_0838_7 crossref_primary_10_1016_j_jpeds_2017_12_051 crossref_primary_10_1111_petr_13657 crossref_primary_10_1002_lt_25951 crossref_primary_10_3389_fimmu_2022_863218 crossref_primary_10_3389_fped_2022_885942 crossref_primary_10_36290_der_2022_030 crossref_primary_10_1007_s12185_023_03562_6 |
Cites_doi | 10.1016/j.iac.2007.06.002 10.1111/j.1399-3046.2005.00474.x 10.1016/j.clim.2010.12.020 10.1046/j.1397-3142.2003.00116.x 10.1016/S0140-6736(97)07302-9 10.1002/pbc.25215 10.1111/j.1600-6143.2006.01304.x 10.1155/2011/768750 10.1016/j.jaci.2010.03.015 10.1084/jem.181.3.927 10.1111/j.1537-2995.2011.03254.x 10.1111/j.1399-3046.2007.00693.x 10.1038/336176a0 10.1016/j.healun.2008.07.015 10.1111/petr.12613 10.4049/jimmunol.164.3.1346 10.1111/j.1399-3046.2006.00538.x 10.1111/j.1399-3046.2007.00883.x 10.1016/S0966-3274(00)00002-2 10.1111/j.1399-3038.2009.00867.x 10.1007/s00431-013-2002-y 10.1128/JVI.74.15.6748-6759.2000 10.1111/j.1399-3046.2012.01684.x 10.1038/ajg.2013.71 10.1128/JVI.78.4.1665-1674.2004 10.1111/j.1399-3046.2006.00542.x 10.1053/j.gastro.2007.08.017 10.1097/01.TP.0000164142.98167.4B 10.1111/j.1600-6143.2006.01717.x 10.1111/petr.12302 10.1111/j.1399-0012.2012.01670.x 10.1111/j.1751-553X.2011.01375.x 10.1111/j.1399-3046.2011.01486.x 10.1111/j.1399-3046.2011.01596.x 10.3928/19382359-20160720-05 10.1111/petr.12338 10.1002/pbc.22183 10.1016/j.transproceed.2010.04.026 10.1016/j.pcl.2012.03.007 10.4049/jimmunol.151.2.1039 10.1111/petr.12205 10.1111/j.1600-6143.2011.03576.x |
ContentType | Journal Article |
Copyright | 2017 Elsevier Inc. Copyright © 2017 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2017 Elsevier Inc. – notice: Copyright © 2017 Elsevier Inc. All rights reserved. |
DBID | NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.jpeds.2017.11.026 |
DatabaseName | PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1097-6833 |
EndPage | 160.e2 |
ExternalDocumentID | 10_1016_j_jpeds_2017_11_026 29395171 S0022347617315822 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: Ashley's Angels |
GroupedDBID | --- --K --M -ET -RU .1- .55 .FO .GJ .XZ .~1 0R~ 123 1B1 1CY 1P~ 1RT 1~. 1~5 354 3O- 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 85S 8P~ 9JM AACTN AAEDT AAEDW AAEJM AAIAV AAIKC AAIKJ AAKOC AALRI AAMNW AAOAW AAQFI AAQQT AAQXK AAWTL AAXUO AAYJJ ABBQC ABFNM ABFRF ABIVO ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABPPZ ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNCT ACRLP ACRZS ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFDAS AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGNAY AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJJEV AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 C5W CAG COF CS3 DU5 EBS EFJIC EFLBG EJD EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q G8K GBLVA HEF HMK HMO HVGLF HZ~ IHE J1W K-O KOM L7B LCYCR M27 M32 M41 MO0 N4W N9A NEJ NQ- O-L O9- OAUVE OB2 OBH OH- OHH OHT OT- OVD P-8 P-9 P2P PC. PQQKQ Q38 R2- RIG ROL RPZ SAE SDF SEL SES SEW SJN SPCBC SSH SSZ T5K TEORI TWZ UGJ UHB UHS UKR UV1 VH1 VVN WH7 WOW WUQ X7M XCE XFW XOL YCJ YFH YOC YOJ YQJ YZZ Z5R ZA5 ZGI ZQV ZXP ZY1 ~G- ~KM AAXKI AFCTW AFJKZ AKRWK NPM AAYXX ABDPE ACRPL ADNMO CITATION 7X8 |
ID | FETCH-LOGICAL-c359t-9b028936961f59bf01e75fe7ad6e5955350494c71c4d406b3212a23ae7063ed13 |
IEDL.DBID | .~1 |
ISSN | 0022-3476 |
IngestDate | Fri Oct 25 07:30:37 EDT 2024 Fri Dec 06 06:33:28 EST 2024 Wed Oct 16 00:50:20 EDT 2024 Fri Feb 23 02:29:26 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | PTAA intestine liver HLH allergy IBD heart kidney multivisceral autoimmunity children solid organ transplantation EBV PTLD SOT immune disorder EGID CNI |
Language | English |
License | Copyright © 2017 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c359t-9b028936961f59bf01e75fe7ad6e5955350494c71c4d406b3212a23ae7063ed13 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-2231-4209 |
PMID | 29395171 |
PQID | 1993994281 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_1993994281 crossref_primary_10_1016_j_jpeds_2017_11_026 pubmed_primary_29395171 elsevier_sciencedirect_doi_10_1016_j_jpeds_2017_11_026 |
PublicationCentury | 2000 |
PublicationDate | May 2018 2018-05-00 20180501 |
PublicationDateYYYYMMDD | 2018-05-01 |
PublicationDate_xml | – month: 05 year: 2018 text: May 2018 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of pediatrics |
PublicationTitleAlternate | J Pediatr |
PublicationYear | 2018 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Ben-Shoshan, Harrington, Soller, Fragapane, Joseph, St Pierre (bib0120) 2010; 125 Dewachter, Vézinet, Nicaise-Roland, Chollet-Martin, Eyraud, Creusvaux (bib0180) 2011; 11 Wisniewski, Lieberman, Nowak-Węgrzyn, Kerkar, Arnon, Iyer (bib0025) 2012; 26 Miloh, Arnon, Roman, Hurlet, Kerkar, Wistinghausen (bib0055) 2011; 15 Romero, Abramowsky, Pillen, Smallwood, Heffron (bib0195) 2003; 7 Upton, Avitzur (bib0205) 2014; 18 Grey, Maquiness (bib0130) 2016; 45 Drakes, Zahorchak, Takayama, Lu, Thomson (bib0170) 2000; 8 Khalid, Zoratti, Stagner, Betensley, Nemeh, Allenspach (bib0185) 2008; 27 Granot, Yakobovich, Bardenstein (bib0010) 2006; 10 Lee, Park, Choe, Lee, Lee (bib0020) 2007; 11 Teachey, Jubelirer, Baluarte, Wade, Manno (bib0045) 2009; 53 Levy, Kamphuis (bib0125) 2012; 59 Khanna, Morelli, Zhong, Takayama, Lu, Thomson (bib0165) 2000; 164 Kindel, Joy, Pahl, Wald (bib0200) 2014; 18 Gao, Lo, Cheney, Kanagawa, Sprent (bib0135) 1988; 336 Bhinder, Heffer, Lee, Chaparro, Tarlo (bib0175) 2011; 18 Steigerwald-Mullen, Kurilla, Braciale (bib0210) 2000; 74 Levy, Davidovits, Cleper, Shapiro (bib0075) 2009; 13 Baan, Mast, Klepper, Mol, Peeters, Korevaar (bib0155) 2005; 80 Li, Goldfinger, Yuan (bib0050) 2012; 52 Doetschman, Sholl, Chen, Gard, Hildeman, Bommireddy (bib0150) 2011; 138 The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee (bib0105) 1998; 351 Dellon, Gonsalves, Hirano, Furuta, Liacouras, Katzka (bib0065) 2013; 108 Ozbek, Ozcay, Avci, Haberal, Haberal (bib0015) 2009; 20 Mouledoux, Albers, Lu, Saville, Moore, Dodd (bib0100) 2014; 18 Wang, Hashimoto, Kubo, Yokochi, Kubo, Suzuki (bib0145) 1995; 181 Nakayama, Hieshima, Nagakubo, Sato, Nakayama, Kawa (bib0215) 2004; 78 Furuta, Liacouras, Collins, Gupta, Justinich, Putnam (bib0070) 2007; 133 Zuo, Rothenberg (bib0110) 2007; 27 Needham, Nicholas, Davis (bib0080) 2015; 19 Ozdemir, Arrey-Mensah, Sorensen (bib0090) 2006; 10 Saeed, Integlia, Pleskow, Calenda, Rohrer, Dayal (bib0190) 2006; 10 Shroff, Mehta, Chinen, Karpen, Davis (bib0035) 2012; 16 Lacaille, Moes, Hugot, Cezard, Goulet, Ruemmele (bib0060) 2006; 6 Schoettler, Elisofon, Kim, Blume, Rodig, Boyer (bib0085) 2015; 62 Venick, McDiarmid, Farmer, Gornbein, Martin, Vargas (bib0040) 2007; 7 Noble, Peake, Lewindon (bib0095) 2011; 15 Garner, Kohen (bib0115) 2008; 19 Chu, Zhang, Zhao, Ji, Zhong, Zhang (bib0160) 2010; 42 De Bruyne, Dullaers, Van Biervliet, Vande Velde, Raes, Gevaert (bib0030) 2013; 172 Bucy, Xu, Li, Huang (bib0140) 1993; 151 Jin, Liu, Dong, Zhang, Zhou, Song (bib0220) 2012; 34 29398055 - J Pediatr. 2018 May;196:10-11 Jin (10.1016/j.jpeds.2017.11.026_bib0220) 2012; 34 Granot (10.1016/j.jpeds.2017.11.026_bib0010) 2006; 10 Levy (10.1016/j.jpeds.2017.11.026_bib0075) 2009; 13 Ozbek (10.1016/j.jpeds.2017.11.026_bib0015) 2009; 20 De Bruyne (10.1016/j.jpeds.2017.11.026_bib0030) 2013; 172 Ben-Shoshan (10.1016/j.jpeds.2017.11.026_bib0120) 2010; 125 Wisniewski (10.1016/j.jpeds.2017.11.026_bib0025) 2012; 26 Wang (10.1016/j.jpeds.2017.11.026_bib0145) 1995; 181 Teachey (10.1016/j.jpeds.2017.11.026_bib0045) 2009; 53 Garner (10.1016/j.jpeds.2017.11.026_bib0115) 2008; 19 Zuo (10.1016/j.jpeds.2017.11.026_bib0110) 2007; 27 Khalid (10.1016/j.jpeds.2017.11.026_bib0185) 2008; 27 Gao (10.1016/j.jpeds.2017.11.026_bib0135) 1988; 336 Shroff (10.1016/j.jpeds.2017.11.026_bib0035) 2012; 16 Nakayama (10.1016/j.jpeds.2017.11.026_bib0215) 2004; 78 Drakes (10.1016/j.jpeds.2017.11.026_bib0170) 2000; 8 Miloh (10.1016/j.jpeds.2017.11.026_bib0055) 2011; 15 Grey (10.1016/j.jpeds.2017.11.026_bib0130) 2016; 45 Steigerwald-Mullen (10.1016/j.jpeds.2017.11.026_bib0210) 2000; 74 Noble (10.1016/j.jpeds.2017.11.026_bib0095) 2011; 15 Levy (10.1016/j.jpeds.2017.11.026_bib0125) 2012; 59 Bhinder (10.1016/j.jpeds.2017.11.026_bib0175) 2011; 18 Dewachter (10.1016/j.jpeds.2017.11.026_bib0180) 2011; 11 The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee (10.1016/j.jpeds.2017.11.026_bib0105) 1998; 351 Ozdemir (10.1016/j.jpeds.2017.11.026_bib0090) 2006; 10 Venick (10.1016/j.jpeds.2017.11.026_bib0040) 2007; 7 Furuta (10.1016/j.jpeds.2017.11.026_bib0070) 2007; 133 Doetschman (10.1016/j.jpeds.2017.11.026_bib0150) 2011; 138 Dellon (10.1016/j.jpeds.2017.11.026_bib0065) 2013; 108 Upton (10.1016/j.jpeds.2017.11.026_bib0205) 2014; 18 Baan (10.1016/j.jpeds.2017.11.026_bib0155) 2005; 80 Bucy (10.1016/j.jpeds.2017.11.026_bib0140) 1993; 151 Chu (10.1016/j.jpeds.2017.11.026_bib0160) 2010; 42 Li (10.1016/j.jpeds.2017.11.026_bib0050) 2012; 52 Khanna (10.1016/j.jpeds.2017.11.026_bib0165) 2000; 164 Lacaille (10.1016/j.jpeds.2017.11.026_bib0060) 2006; 6 Romero (10.1016/j.jpeds.2017.11.026_bib0195) 2003; 7 Kindel (10.1016/j.jpeds.2017.11.026_bib0200) 2014; 18 Saeed (10.1016/j.jpeds.2017.11.026_bib0190) 2006; 10 Schoettler (10.1016/j.jpeds.2017.11.026_bib0085) 2015; 62 Needham (10.1016/j.jpeds.2017.11.026_bib0080) 2015; 19 Lee (10.1016/j.jpeds.2017.11.026_bib0020) 2007; 11 Mouledoux (10.1016/j.jpeds.2017.11.026_bib0100) 2014; 18 |
References_xml | – volume: 181 start-page: 927 year: 1995 end-page: 941 ident: bib0145 article-title: T-cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection publication-title: J Exp Med contributor: fullname: Suzuki – volume: 133 start-page: 1342 year: 2007 end-page: 1363 ident: bib0070 article-title: Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment publication-title: Gastroenterology contributor: fullname: Putnam – volume: 15 start-page: 451 year: 2011 end-page: 454 ident: bib0095 article-title: Increase in de novo allergies after paediatric liver transplantation: the Brisbane experience publication-title: Pediatr Transplant contributor: fullname: Lewindon – volume: 53 start-page: 1114 year: 2009 end-page: 1116 ident: bib0045 article-title: Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant publication-title: Pediatr Blood Cancer contributor: fullname: Manno – volume: 11 start-page: 518 year: 2007 end-page: 523 ident: bib0020 article-title: The development of eosinophilic colitis after liver transplantation in children publication-title: Pediatr Transplant contributor: fullname: Lee – volume: 18 start-page: 491 year: 2014 end-page: 496 ident: bib0200 article-title: Eosinophilic esophagitis in children following cardiac transplantation: association with post-transplant lymphoproliferative disorder and other transplant outcomes publication-title: Pediatr Transplant contributor: fullname: Wald – volume: 18 start-page: 665 year: 2014 end-page: 667 ident: bib0205 article-title: Eosinophilic esophagitis after organ transplantation and post-transplant lymphoproliferative disorder: more questions than answers publication-title: Pediatr Transplant contributor: fullname: Avitzur – volume: 138 start-page: 321 year: 2011 end-page: 330 ident: bib0150 article-title: Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis publication-title: Clin Immunol contributor: fullname: Bommireddy – volume: 18 start-page: 197 year: 2014 end-page: 203 ident: bib0100 article-title: Clinical predictors of autoimmune and severe atopic disease in pediatric heart transplant recipients publication-title: Pediatr Transplant contributor: fullname: Dodd – volume: 7 start-page: 955 year: 2007 end-page: 963 ident: bib0040 article-title: Rejection and steroid dependence: unique risk factors in the development of pediatric post-transplant de novo autoimmune hepatitis publication-title: Am J Transplant contributor: fullname: Vargas – volume: 11 start-page: 1531 year: 2011 end-page: 1534 ident: bib0180 article-title: Passive transient transfer of peanut allergy by liver transplantation publication-title: Am J Transplant contributor: fullname: Creusvaux – volume: 13 start-page: 63 year: 2009 end-page: 69 ident: bib0075 article-title: New-onset post-transplantation food allergy in children- is it attributable only to the immunosuppressive protocol? publication-title: Pediatr Transplant contributor: fullname: Shapiro – volume: 74 start-page: 6748 year: 2000 end-page: 6759 ident: bib0210 article-title: Type 2 cytokines predominate in the human CD4(+) T-lymphocyte response to Epstein-Barr virus nuclear antigen 1 publication-title: J Virol contributor: fullname: Braciale – volume: 20 start-page: 741 year: 2009 end-page: 747 ident: bib0015 article-title: Food allergy after liver transplantation in children: a prospective study publication-title: Pediatr Allergy Immunol contributor: fullname: Haberal – volume: 42 start-page: 2599 year: 2010 end-page: 2601 ident: bib0160 article-title: Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients publication-title: Transplant Proc contributor: fullname: Zhang – volume: 10 start-page: 690 year: 2006 end-page: 693 ident: bib0010 article-title: Tacrolimus immunosuppression—an association with asymptomatic eosinophilia and elevated total and specific IgE levels publication-title: Pediatr Transplant contributor: fullname: Bardenstein – volume: 172 start-page: 1069 year: 2013 end-page: 1075 ident: bib0030 article-title: Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study publication-title: Eur J Pediatr contributor: fullname: Gevaert – volume: 108 start-page: 679 year: 2013 end-page: 692 ident: bib0065 article-title: ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) publication-title: Am J Gastroenterol contributor: fullname: Katzka – volume: 45 start-page: e280 year: 2016 end-page: e286 ident: bib0130 article-title: Atopic dermatitis: update for pediatricians publication-title: Pediatr Ann contributor: fullname: Maquiness – volume: 27 start-page: 1162 year: 2008 end-page: 1164 ident: bib0185 article-title: Transfer of peanut allergy from the donor to a lung transplant recipient publication-title: J Heart Lung Transplant contributor: fullname: Allenspach – volume: 351 start-page: 1225 year: 1998 end-page: 1232 ident: bib0105 article-title: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC publication-title: Lancet contributor: fullname: The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee – volume: 8 start-page: 17 year: 2000 end-page: 29 ident: bib0170 article-title: Chemokine and chemokine receptor expression by liver-derived dendritic cells: MIP-1alpha production is induced by bacterial lipopolysaccharide and interaction with allogeneic T cells publication-title: Transpl Immunol contributor: fullname: Thomson – volume: 16 start-page: 379 year: 2012 end-page: 384 ident: bib0035 article-title: Presentation of atopic disease in a large cohort of pediatric liver transplant recipients publication-title: Pediatr Transplant contributor: fullname: Davis – volume: 10 start-page: 730 year: 2006 end-page: 735 ident: bib0190 article-title: Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis publication-title: Pediatr Transplant contributor: fullname: Dayal – volume: 52 start-page: 48 year: 2012 end-page: 54 ident: bib0050 article-title: Autoimmune hemolytic anemia in pediatric liver or combined liver and small bowel transplant patients: a case series and review of the literature publication-title: Transfusion contributor: fullname: Yuan – volume: 19 start-page: 827 year: 2015 end-page: 835 ident: bib0080 article-title: Food allergies developing after solid organ transplant publication-title: Pediatr Transplant contributor: fullname: Davis – volume: 10 start-page: 380 year: 2006 end-page: 383 ident: bib0090 article-title: Development of multiple food allergies in children taking tacrolimus after heart and liver transplantation publication-title: Pediatr Transplant contributor: fullname: Sorensen – volume: 18 start-page: 154 year: 2011 end-page: 156 ident: bib0175 article-title: Development of transient peanut allergy following lung transplantation: a case report publication-title: Can Respir J contributor: fullname: Tarlo – volume: 164 start-page: 1346 year: 2000 end-page: 1354 ident: bib0165 article-title: Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo publication-title: J Immunol contributor: fullname: Thomson – volume: 59 start-page: 345 year: 2012 end-page: 364 ident: bib0125 article-title: Systemic lupus erythematosus in children and adolescents publication-title: Pediatr Clin North Am contributor: fullname: Kamphuis – volume: 151 start-page: 1039 year: 1993 end-page: 1050 ident: bib0140 article-title: Cyclosporin A-induced autoimmune disease in mice publication-title: J Immunol contributor: fullname: Huang – volume: 80 start-page: 110 year: 2005 end-page: 117 ident: bib0155 article-title: Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells publication-title: Transplantation contributor: fullname: Korevaar – volume: 7 start-page: 484 year: 2003 end-page: 488 ident: bib0195 article-title: Peripheral eosinophilia and eosinophilic gastroenteritis after pediatric liver transplantation publication-title: Pediatr Transplant contributor: fullname: Heffron – volume: 6 start-page: 1072 year: 2006 end-page: 1076 ident: bib0060 article-title: Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation publication-title: Am J Transplant contributor: fullname: Ruemmele – volume: 19 start-page: 45 year: 2008 end-page: 50 ident: bib0115 article-title: Changes in the prevalence of asthma among Canadian children publication-title: Health Rep contributor: fullname: Kohen – volume: 125 start-page: 1327 year: 2010 end-page: 1335 ident: bib0120 article-title: A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada publication-title: J Allergy Clin Immunol contributor: fullname: St Pierre – volume: 26 start-page: E365 year: 2012 end-page: E371 ident: bib0025 article-title: De-novo food sensitization and eosinophilic gastrointestinal disease in children post-liver transplantation publication-title: Clin Transplant contributor: fullname: Iyer – volume: 336 start-page: 176 year: 1988 end-page: 179 ident: bib0135 article-title: Abnormal differentiation of thymocytes in mice treated with cyclosporin A publication-title: Nature contributor: fullname: Sprent – volume: 62 start-page: 214 year: 2015 end-page: 218 ident: bib0085 article-title: Treatment and outcomes of immune cytopenias following solid organ transplant in children publication-title: Pediatr Blood Cancer contributor: fullname: Boyer – volume: 27 start-page: 443 year: 2007 end-page: 455 ident: bib0110 article-title: Gastrointestinal eosinophilia publication-title: Immunol Allergy Clin North Am contributor: fullname: Rothenberg – volume: 78 start-page: 1665 year: 2004 end-page: 1674 ident: bib0215 article-title: Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus publication-title: J Virol contributor: fullname: Kawa – volume: 15 start-page: 870 year: 2011 end-page: 878 ident: bib0055 article-title: Autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura in pediatric solid organ transplant recipients, report of five cases and review of the literature publication-title: Pediatr Transplant contributor: fullname: Wistinghausen – volume: 34 start-page: 164 year: 2012 end-page: 171 ident: bib0220 article-title: Type 2 polarized immune response holds a major position in Epstein-Barr virus-related idiopathic thrombocytopenic purpura (EBV-ITP) publication-title: Int J Lab Hematol contributor: fullname: Song – volume: 27 start-page: 443 year: 2007 ident: 10.1016/j.jpeds.2017.11.026_bib0110 article-title: Gastrointestinal eosinophilia publication-title: Immunol Allergy Clin North Am doi: 10.1016/j.iac.2007.06.002 contributor: fullname: Zuo – volume: 10 start-page: 380 year: 2006 ident: 10.1016/j.jpeds.2017.11.026_bib0090 article-title: Development of multiple food allergies in children taking tacrolimus after heart and liver transplantation publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2005.00474.x contributor: fullname: Ozdemir – volume: 138 start-page: 321 year: 2011 ident: 10.1016/j.jpeds.2017.11.026_bib0150 article-title: Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis publication-title: Clin Immunol doi: 10.1016/j.clim.2010.12.020 contributor: fullname: Doetschman – volume: 7 start-page: 484 year: 2003 ident: 10.1016/j.jpeds.2017.11.026_bib0195 article-title: Peripheral eosinophilia and eosinophilic gastroenteritis after pediatric liver transplantation publication-title: Pediatr Transplant doi: 10.1046/j.1397-3142.2003.00116.x contributor: fullname: Romero – volume: 351 start-page: 1225 year: 1998 ident: 10.1016/j.jpeds.2017.11.026_bib0105 article-title: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC publication-title: Lancet doi: 10.1016/S0140-6736(97)07302-9 contributor: fullname: The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee – volume: 62 start-page: 214 year: 2015 ident: 10.1016/j.jpeds.2017.11.026_bib0085 article-title: Treatment and outcomes of immune cytopenias following solid organ transplant in children publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.25215 contributor: fullname: Schoettler – volume: 6 start-page: 1072 year: 2006 ident: 10.1016/j.jpeds.2017.11.026_bib0060 article-title: Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2006.01304.x contributor: fullname: Lacaille – volume: 18 start-page: 154 year: 2011 ident: 10.1016/j.jpeds.2017.11.026_bib0175 article-title: Development of transient peanut allergy following lung transplantation: a case report publication-title: Can Respir J doi: 10.1155/2011/768750 contributor: fullname: Bhinder – volume: 125 start-page: 1327 year: 2010 ident: 10.1016/j.jpeds.2017.11.026_bib0120 article-title: A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.03.015 contributor: fullname: Ben-Shoshan – volume: 181 start-page: 927 year: 1995 ident: 10.1016/j.jpeds.2017.11.026_bib0145 article-title: T-cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection publication-title: J Exp Med doi: 10.1084/jem.181.3.927 contributor: fullname: Wang – volume: 52 start-page: 48 year: 2012 ident: 10.1016/j.jpeds.2017.11.026_bib0050 article-title: Autoimmune hemolytic anemia in pediatric liver or combined liver and small bowel transplant patients: a case series and review of the literature publication-title: Transfusion doi: 10.1111/j.1537-2995.2011.03254.x contributor: fullname: Li – volume: 11 start-page: 518 year: 2007 ident: 10.1016/j.jpeds.2017.11.026_bib0020 article-title: The development of eosinophilic colitis after liver transplantation in children publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2007.00693.x contributor: fullname: Lee – volume: 336 start-page: 176 year: 1988 ident: 10.1016/j.jpeds.2017.11.026_bib0135 article-title: Abnormal differentiation of thymocytes in mice treated with cyclosporin A publication-title: Nature doi: 10.1038/336176a0 contributor: fullname: Gao – volume: 27 start-page: 1162 year: 2008 ident: 10.1016/j.jpeds.2017.11.026_bib0185 article-title: Transfer of peanut allergy from the donor to a lung transplant recipient publication-title: J Heart Lung Transplant doi: 10.1016/j.healun.2008.07.015 contributor: fullname: Khalid – volume: 19 start-page: 827 year: 2015 ident: 10.1016/j.jpeds.2017.11.026_bib0080 article-title: Food allergies developing after solid organ transplant publication-title: Pediatr Transplant doi: 10.1111/petr.12613 contributor: fullname: Needham – volume: 164 start-page: 1346 year: 2000 ident: 10.1016/j.jpeds.2017.11.026_bib0165 article-title: Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo publication-title: J Immunol doi: 10.4049/jimmunol.164.3.1346 contributor: fullname: Khanna – volume: 10 start-page: 730 year: 2006 ident: 10.1016/j.jpeds.2017.11.026_bib0190 article-title: Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2006.00538.x contributor: fullname: Saeed – volume: 13 start-page: 63 year: 2009 ident: 10.1016/j.jpeds.2017.11.026_bib0075 article-title: New-onset post-transplantation food allergy in children- is it attributable only to the immunosuppressive protocol? publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2007.00883.x contributor: fullname: Levy – volume: 8 start-page: 17 year: 2000 ident: 10.1016/j.jpeds.2017.11.026_bib0170 article-title: Chemokine and chemokine receptor expression by liver-derived dendritic cells: MIP-1alpha production is induced by bacterial lipopolysaccharide and interaction with allogeneic T cells publication-title: Transpl Immunol doi: 10.1016/S0966-3274(00)00002-2 contributor: fullname: Drakes – volume: 20 start-page: 741 year: 2009 ident: 10.1016/j.jpeds.2017.11.026_bib0015 article-title: Food allergy after liver transplantation in children: a prospective study publication-title: Pediatr Allergy Immunol doi: 10.1111/j.1399-3038.2009.00867.x contributor: fullname: Ozbek – volume: 172 start-page: 1069 year: 2013 ident: 10.1016/j.jpeds.2017.11.026_bib0030 article-title: Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study publication-title: Eur J Pediatr doi: 10.1007/s00431-013-2002-y contributor: fullname: De Bruyne – volume: 74 start-page: 6748 year: 2000 ident: 10.1016/j.jpeds.2017.11.026_bib0210 article-title: Type 2 cytokines predominate in the human CD4(+) T-lymphocyte response to Epstein-Barr virus nuclear antigen 1 publication-title: J Virol doi: 10.1128/JVI.74.15.6748-6759.2000 contributor: fullname: Steigerwald-Mullen – volume: 16 start-page: 379 year: 2012 ident: 10.1016/j.jpeds.2017.11.026_bib0035 article-title: Presentation of atopic disease in a large cohort of pediatric liver transplant recipients publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2012.01684.x contributor: fullname: Shroff – volume: 108 start-page: 679 year: 2013 ident: 10.1016/j.jpeds.2017.11.026_bib0065 article-title: ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) publication-title: Am J Gastroenterol doi: 10.1038/ajg.2013.71 contributor: fullname: Dellon – volume: 78 start-page: 1665 year: 2004 ident: 10.1016/j.jpeds.2017.11.026_bib0215 article-title: Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus publication-title: J Virol doi: 10.1128/JVI.78.4.1665-1674.2004 contributor: fullname: Nakayama – volume: 10 start-page: 690 year: 2006 ident: 10.1016/j.jpeds.2017.11.026_bib0010 article-title: Tacrolimus immunosuppression—an association with asymptomatic eosinophilia and elevated total and specific IgE levels publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2006.00542.x contributor: fullname: Granot – volume: 133 start-page: 1342 year: 2007 ident: 10.1016/j.jpeds.2017.11.026_bib0070 article-title: Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.08.017 contributor: fullname: Furuta – volume: 80 start-page: 110 year: 2005 ident: 10.1016/j.jpeds.2017.11.026_bib0155 article-title: Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells publication-title: Transplantation doi: 10.1097/01.TP.0000164142.98167.4B contributor: fullname: Baan – volume: 7 start-page: 955 year: 2007 ident: 10.1016/j.jpeds.2017.11.026_bib0040 article-title: Rejection and steroid dependence: unique risk factors in the development of pediatric post-transplant de novo autoimmune hepatitis publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2006.01717.x contributor: fullname: Venick – volume: 18 start-page: 491 year: 2014 ident: 10.1016/j.jpeds.2017.11.026_bib0200 article-title: Eosinophilic esophagitis in children following cardiac transplantation: association with post-transplant lymphoproliferative disorder and other transplant outcomes publication-title: Pediatr Transplant doi: 10.1111/petr.12302 contributor: fullname: Kindel – volume: 26 start-page: E365 year: 2012 ident: 10.1016/j.jpeds.2017.11.026_bib0025 article-title: De-novo food sensitization and eosinophilic gastrointestinal disease in children post-liver transplantation publication-title: Clin Transplant doi: 10.1111/j.1399-0012.2012.01670.x contributor: fullname: Wisniewski – volume: 34 start-page: 164 year: 2012 ident: 10.1016/j.jpeds.2017.11.026_bib0220 article-title: Type 2 polarized immune response holds a major position in Epstein-Barr virus-related idiopathic thrombocytopenic purpura (EBV-ITP) publication-title: Int J Lab Hematol doi: 10.1111/j.1751-553X.2011.01375.x contributor: fullname: Jin – volume: 15 start-page: 451 year: 2011 ident: 10.1016/j.jpeds.2017.11.026_bib0095 article-title: Increase in de novo allergies after paediatric liver transplantation: the Brisbane experience publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2011.01486.x contributor: fullname: Noble – volume: 19 start-page: 45 year: 2008 ident: 10.1016/j.jpeds.2017.11.026_bib0115 article-title: Changes in the prevalence of asthma among Canadian children publication-title: Health Rep contributor: fullname: Garner – volume: 15 start-page: 870 year: 2011 ident: 10.1016/j.jpeds.2017.11.026_bib0055 article-title: Autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura in pediatric solid organ transplant recipients, report of five cases and review of the literature publication-title: Pediatr Transplant doi: 10.1111/j.1399-3046.2011.01596.x contributor: fullname: Miloh – volume: 45 start-page: e280 year: 2016 ident: 10.1016/j.jpeds.2017.11.026_bib0130 article-title: Atopic dermatitis: update for pediatricians publication-title: Pediatr Ann doi: 10.3928/19382359-20160720-05 contributor: fullname: Grey – volume: 18 start-page: 665 year: 2014 ident: 10.1016/j.jpeds.2017.11.026_bib0205 article-title: Eosinophilic esophagitis after organ transplantation and post-transplant lymphoproliferative disorder: more questions than answers publication-title: Pediatr Transplant doi: 10.1111/petr.12338 contributor: fullname: Upton – volume: 53 start-page: 1114 year: 2009 ident: 10.1016/j.jpeds.2017.11.026_bib0045 article-title: Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.22183 contributor: fullname: Teachey – volume: 42 start-page: 2599 year: 2010 ident: 10.1016/j.jpeds.2017.11.026_bib0160 article-title: Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients publication-title: Transplant Proc doi: 10.1016/j.transproceed.2010.04.026 contributor: fullname: Chu – volume: 59 start-page: 345 year: 2012 ident: 10.1016/j.jpeds.2017.11.026_bib0125 article-title: Systemic lupus erythematosus in children and adolescents publication-title: Pediatr Clin North Am doi: 10.1016/j.pcl.2012.03.007 contributor: fullname: Levy – volume: 151 start-page: 1039 year: 1993 ident: 10.1016/j.jpeds.2017.11.026_bib0140 article-title: Cyclosporin A-induced autoimmune disease in mice publication-title: J Immunol doi: 10.4049/jimmunol.151.2.1039 contributor: fullname: Bucy – volume: 18 start-page: 197 year: 2014 ident: 10.1016/j.jpeds.2017.11.026_bib0100 article-title: Clinical predictors of autoimmune and severe atopic disease in pediatric heart transplant recipients publication-title: Pediatr Transplant doi: 10.1111/petr.12205 contributor: fullname: Mouledoux – volume: 11 start-page: 1531 year: 2011 ident: 10.1016/j.jpeds.2017.11.026_bib0180 article-title: Passive transient transfer of peanut allergy by liver transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2011.03576.x contributor: fullname: Dewachter |
SSID | ssj0009400 |
Score | 2.46785 |
Snippet | To describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity.
A cross-sectional, cohort study of... OBJECTIVESTo describe the prevalence, natural course, outcome, and risk factors of post-transplant de novo allergy and autoimmunity.STUDY DESIGNA... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 154 |
SubjectTerms | allergy autoimmunity children heart immune disorder intestine kidney liver multivisceral solid organ transplantation |
Title | De Novo Allergy and Immune-Mediated Disorders Following Solid-Organ Transplantation—Prevalence, Natural History, and Risk Factors |
URI | https://dx.doi.org/10.1016/j.jpeds.2017.11.026 https://www.ncbi.nlm.nih.gov/pubmed/29395171 https://search.proquest.com/docview/1993994281 |
Volume | 196 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1da9swFBWlg9GXso-uzboFDfYYt5FlWdFjyBbSjeRhXaFvQrLlkjTYoUla8lIK_Qv7hfslu1eyOwZtH_ZoYyGhK98PdM65hHzOTCwlZ3mkjFVRYm03sogEKCTUQLERrufRhONJOjpLvp2L8y0yaLgwCKusfX_w6d5b12-O6908XkynyPGF0JZAGQ5zCYhzyGAXXexicHT7F-aBjb8fFMPh60Z5yGO8ZguXo2Y3k0co5YkKC49Hp6eyTx-Fhq_Ibp0-0n5Y4Wuy5co35OW4viB_S-6_ODqprivaR4rfxYaaMqcnyAFx0dh35XA5bRQ3l3QIp6C6gehFT6v5NI88M5MGwfO5Cayk8vfdLxR6Mp6e1KET46U6aBAY2XT8FD-my0s6DL179sjZ8OvPwSiq-yxEGRdqFSmL143Y2I8VQtmiy5wUhZMmT51QQnCBIjKZZFmSQ_y3HMKdiblxEvIblzP-jmyXVekOCBXCFYrFmelhqpPGNhaWc2OLrFuIjCct0mn2Vy-CnIZucGYz7c2h0RxQmGgwR4ukjQ30P6dCg8N_fuCnxmIa_he8BDGlq9ZLjYBFpaDoYi2yH0z5sBJIfSDhlOz9_057SHbgqRcAkR_I9upq7T5C0rKybX8q2-RF_-T7aPIHBhDryw |
link.rule.ids | 314,780,784,4502,24116,27924,27925,45585,45679 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB1RkFouCPrFUkpdqccNrON4vT4i2tXSsntoQeJm2YmDlqJkxS4gLqhS_0J_YX9JZ-yECqntodd8yFZmMvNGfvMG4F1uU6UELxJtnU4y53qJIyZAqbAGSq30g8AmHE_6o5Ps46k8XYKDtheGaJVN7I8xPUTr5spe8zX3ZtMp9fhiasuwDMe1JOa5R7CSSUS_6NS7d795HjT5-14yHB9vpYcCyet85gsS7eZql7Q8SWLhz-npb_AzpKHhOqw1-JHtxy1uwJKvnsLjcXNC_gy-v_dsUl_XbJ96_M5uma0KdkhNID4Zh7EcvmCt5OacDdEN6htMX-xLfTEtktCayaLi-YWNbUnVz28_SOnJhv6kLpvYoNXBosLIbTcs8Xk6_8qGcXjPczgZfjg-GCXNoIUkF1IvEu3ovJEm-_FSalf2uFey9MoWfS-1lEKSikyueJ4VCACcwHxnU2G9QoDjCy5ewHJVV34TmJS-1DzN7YCwTj91qXRCWFfmvVLmIutAt_2-Zhb1NExLNDs3wRyGzIGViUFzdKDf2sA8cAuDEf_fL75tLWbwh6FTEFv5-mpuiLGoNVZdvAMvoynvd4LYBxGn4lv_u-wbeDI6Hh-Zo8PJp1ewincGkR25DcuLyyv_GhHMwu0ED_0Fm3HtaA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=De+Novo+Allergy+and+Immune-Mediated+Disorders+Following+Solid-Organ+Transplantation%E2%80%94Prevalence%2C+Natural+History%2C+and+Risk+Factors&rft.jtitle=The+Journal+of+pediatrics&rft.au=Marcus%2C+Nufar&rft.au=Amir%2C+Achiya+Z.&rft.au=Grunebaum%2C+Eyal&rft.au=Dipchand%2C+Anne&rft.date=2018-05-01&rft.issn=0022-3476&rft.volume=196&rft.spage=154&rft.epage=160.e2&rft_id=info:doi/10.1016%2Fj.jpeds.2017.11.026&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jpeds_2017_11_026 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3476&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3476&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3476&client=summon |