Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours

Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and cancer recurrence in patient...

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Published inAdvances in medical sciences Vol. 65; no. 1; pp. 163 - 169
Main Author Musa, Marahaini
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2020
Subjects
Biomarkers, Tumor - genetics
Cancer
Cancer-Associated Fibroblasts - metabolism
Cancer-Associated Fibroblasts - pathology
Gene Expression Regulation, Neoplastic
Humans
Microenvironment
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Single-cell analysis
Single-Cell Analysis - methods
Solid tumour
Stromal Cells - metabolism
Stromal Cells - pathology
Stromal fibroblast
Tumor Microenvironment
Stromal fibroblast
Microenvironment
Single-cell analysis
Solid tumour
Cancer
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Abstract Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and cancer recurrence in patients. Certain limitations presented by conventional experimental designs and techniques in cancer research have led to poor understanding of the fundamental basis of cancer niche. Recent developments in single-cell techniques allow more in-depth studies of the tumour microenvironment. Analyses at the single-cell level enables the detection of rare cell types, characterization of intra-tumour cellular heterogeneity and analysis of the lineage output of malignant cells. This subsequently, provides valuable insights on better diagnostic methods and treatment avenues for cancer. This review explores the recent advancements and applications of single-cell technologies in cancer research pertaining to the study of stromal fibroblasts in the microenvironment of solid tumours.
AbstractList Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and cancer recurrence in patients. Certain limitations presented by conventional experimental designs and techniques in cancer research have led to poor understanding of the fundamental basis of cancer niche. Recent developments in single-cell techniques allow more in-depth studies of the tumour microenvironment. Analyses at the single-cell level enables the detection of rare cell types, characterization of intra-tumour cellular heterogeneity and analysis of the lineage output of malignant cells. This subsequently, provides valuable insights on better diagnostic methods and treatment avenues for cancer. This review explores the recent advancements and applications of single-cell technologies in cancer research pertaining to the study of stromal fibroblasts in the microenvironment of solid tumours.
Author Musa, Marahaini
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Keywords Stromal fibroblast
Microenvironment
Single-cell analysis
Solid tumour
Cancer
Language English
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Snippet Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts....
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SubjectTerms Biomarkers, Tumor - genetics
Cancer
Cancer-Associated Fibroblasts - metabolism
Cancer-Associated Fibroblasts - pathology
Gene Expression Regulation, Neoplastic
Humans
Microenvironment
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Single-cell analysis
Single-Cell Analysis - methods
Solid tumour
Stromal Cells - metabolism
Stromal Cells - pathology
Stromal fibroblast
Tumor Microenvironment
Title Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours
URI https://dx.doi.org/10.1016/j.advms.2019.12.001
https://www.ncbi.nlm.nih.gov/pubmed/31972467
https://search.proquest.com/docview/2344271944
Volume 65
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