Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease

• Published in: Experimental gerontology Vol. 150; p. 111376
• Main Authors: Hou, Yichao, Li, Xingqi, Liu, Chang, Zhang, Ming, Zhang, Xiaoying, Ge, Shaoyang, Zhao, Liang
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.07.2021
• Subjects: Microglia; MPTP; Neuroinflammation; Parkinson's disease; Short-chain fatty acids; Short-chain fatty acids; Neuroinflammation; Parkinson's disease; MPTP; Microglia
• ISSN: 0531-5565; 1873-6815; 1873-6815
• DOI: 10.1016/j.exger.2021.111376

Gut microbial metabolites, SCFAs, were related with the occurrence and development of Parkinson's disease (PD). But the effects of different short-chain fatty acids (SCFAs) on PD and involving mechanisms are still undefined. In this study we evaluate the effects of three dominant SCFAs (acetate...