LEPR hypomethylation is significantly associated with gastric cancer in males

• Published in: Experimental and molecular pathology Vol. 116; p. 104493
• Main Authors: Yu, Hang, Pan, Ranran, Qi, Yuanling, Zheng, Zhonghua, Li, Jing, Li, Hongxiang, Ying, Jieer, Xu, Mingqing, Duan, Shiwei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2020
• Subjects: Adult; Diagnosis; DNA Methylation - genetics; Female; Gastric cancer; Gene Expression Regulation, Neoplastic - genetics; Humans; Leptin receptor; Male; Methylation; Middle Aged; Neoplasm Recurrence, Local - genetics; Prognosis; Promoter Regions, Genetic - genetics; Receptors, Leptin - genetics; Recurrence; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Recurrence; Diagnosis; Leptin receptor; Methylation; Gastric cancer

Previous study has shown LEPR is a candidate gene of prediction and treatment of gastric cancer (GC). The purpose of this study was to test whether LEPR methylation could predict the risk of GC. Tumor tissues and 5-cm adjacent non-tumor tissues from 117 newly diagnosed and untreated GC patients were...