Links between atherosclerotic and periodontal disease

Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiolo...

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Published inExperimental and molecular pathology Vol. 100; no. 1; pp. 220 - 235
Main Authors Chistiakov, Dimitry A., Orekhov, Alexander N., Bobryshev, Yuri V.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.02.2016
Subjects
Animals
Apolipoproteins E - deficiency
Atherogenesis
Atherosclerosis
Atherosclerosis - complications
Cardiovascular Diseases - etiology
Disease Models, Animal
Gingipain
Humans
Inflammation
LPS
Periodontal Diseases - complications
Periodontal Diseases - therapy
Periodontitis
Porphyromonas gingivalis
Smoking - adverse effects
Porphyromonas gingivalis
Atherogenesis
Periodontitis
Gingipain
Atherosclerosis
Inflammation
LPS
Online AccessGet full text
ISSN0014-4800
1096-0945
1096-0945
DOI10.1016/j.yexmp.2016.01.006

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Abstract Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiological studies suggest that PD is strongly associated with increased CVD risk. Biochemical and physiological analyses involving in vitro experiments, animal models, and clinical studies provided evidence for the substantial impact of periodontal pathogens, their virulence factors, and bacterial endotoxins on all general pathogenic CVD mechanisms such as endothelial dysfunction, systemic inflammation, oxidative stress, foam cell formation, lipid accumulation, vascular remodeling, and atherothrombosis. Interventional studies showed moderate beneficial effects of PD treatment on reducing systemic inflammation and endothelial dysfunction. However, no interventional studies were performed to assess whether periodontal therapy can primarily prevent CVD. In summary, current data suggest for a strong contributory role of periodontal infection to CVD but cannot provide sufficient evidence for a role of PD as a cause for cardiovascular pathology.
AbstractList Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiological studies suggest that PD is strongly associated with increased CVD risk. Biochemical and physiological analyses involving in vitro experiments, animal models, and clinical studies provided evidence for the substantial impact of periodontal pathogens, their virulence factors, and bacterial endotoxins on all general pathogenic CVD mechanisms such as endothelial dysfunction, systemic inflammation, oxidative stress, foam cell formation, lipid accumulation, vascular remodeling, and atherothrombosis. Interventional studies showed moderate beneficial effects of PD treatment on reducing systemic inflammation and endothelial dysfunction. However, no interventional studies were performed to assess whether periodontal therapy can primarily prevent CVD. In summary, current data suggest for a strong contributory role of periodontal infection to CVD but cannot provide sufficient evidence for a role of PD as a cause for cardiovascular pathology.
Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiological studies suggest that PD is strongly associated with increased CVD risk. Biochemical and physiological analyses involving in vitro experiments, animal models, and clinical studies provided evidence for the substantial impact of periodontal pathogens, their virulence factors, and bacterial endotoxins on all general pathogenic CVD mechanisms such as endothelial dysfunction, systemic inflammation, oxidative stress, foam cell formation, lipid accumulation, vascular remodeling, and atherothrombosis. Interventional studies showed moderate beneficial effects of PD treatment on reducing systemic inflammation and endothelial dysfunction. However, no interventional studies were performed to assess whether periodontal therapy can primarily prevent CVD. In summary, current data suggest for a strong contributory role of periodontal infection to CVD but cannot provide sufficient evidence for a role of PD as a cause for cardiovascular pathology.Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiological studies suggest that PD is strongly associated with increased CVD risk. Biochemical and physiological analyses involving in vitro experiments, animal models, and clinical studies provided evidence for the substantial impact of periodontal pathogens, their virulence factors, and bacterial endotoxins on all general pathogenic CVD mechanisms such as endothelial dysfunction, systemic inflammation, oxidative stress, foam cell formation, lipid accumulation, vascular remodeling, and atherothrombosis. Interventional studies showed moderate beneficial effects of PD treatment on reducing systemic inflammation and endothelial dysfunction. However, no interventional studies were performed to assess whether periodontal therapy can primarily prevent CVD. In summary, current data suggest for a strong contributory role of periodontal infection to CVD but cannot provide sufficient evidence for a role of PD as a cause for cardiovascular pathology.
Author Orekhov, Alexander N.
Chistiakov, Dimitry A.
Bobryshev, Yuri V.
Author_xml – sequence: 1
  givenname: Dimitry A.
  surname: Chistiakov
  fullname: Chistiakov, Dimitry A.
  organization: Department of Molecular Genetic Diagnostics and Cell Biology, Institute of Pediatrics, Research Center for Children's Health, 119991 Moscow, Russia
– sequence: 2
  givenname: Alexander N.
  surname: Orekhov
  fullname: Orekhov, Alexander N.
  organization: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia
– sequence: 3
  givenname: Yuri V.
  surname: Bobryshev
  fullname: Bobryshev, Yuri V.
  email: y.bobryshev@unsw.edu.au
  organization: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26777261$$D View this record in MEDLINE/PubMed
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ISSN 0014-4800
1096-0945
IngestDate Thu Sep 04 15:25:55 EDT 2025
Thu Apr 03 07:11:15 EDT 2025
Tue Jul 01 01:56:47 EDT 2025
Thu Apr 24 23:08:31 EDT 2025
Fri Feb 23 02:30:57 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Porphyromonas gingivalis
Atherogenesis
Periodontitis
Gingipain
Atherosclerosis
Inflammation
LPS
Language English
License Copyright © 2016 Elsevier Inc. All rights reserved.
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PublicationTitle Experimental and molecular pathology
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  article-title: The circular relationship between matrix metalloproteinase-9 and inflammation following myocardial infarction
  publication-title: IUBMB Life
  doi: 10.1002/iub.1408
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Snippet Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders,...
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SubjectTerms Animals
Apolipoproteins E - deficiency
Atherogenesis
Atherosclerosis
Atherosclerosis - complications
Cardiovascular Diseases - etiology
Disease Models, Animal
Gingipain
Humans
Inflammation
LPS
Periodontal Diseases - complications
Periodontal Diseases - therapy
Periodontitis
Porphyromonas gingivalis
Smoking - adverse effects
Title Links between atherosclerotic and periodontal disease
URI https://dx.doi.org/10.1016/j.yexmp.2016.01.006
https://www.ncbi.nlm.nih.gov/pubmed/26777261
https://www.proquest.com/docview/1762029218
Volume 100
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