Chromatographic profile of high boiling point organic acids in human urine

The profile of high boiling point organic acids in urine samples from both normal subjects and patients suspected of having some form of metabolic disorder has been determined by combined gas chromatography—mass spectrometry. Fifteen different compounds eluting after hippuric acid have been identifi...

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Published inJournal of chromatography Vol. 145; no. 2; pp. 177 - 184
Main Authors Brown, Garry K., Stokke, Oddvar, Jellum, Egil
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.1978
Subjects
Acids - urine
Chromatography, Gas
Cinnamates - urine
Citrates - urine
Glycine - analogs & derivatives
Glycine - urine
Hippurates - urine
Hot Temperature
Humans
Mass Spectrometry
Metabolism, Inborn Errors - urine
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Abstract The profile of high boiling point organic acids in urine samples from both normal subjects and patients suspected of having some form of metabolic disorder has been determined by combined gas chromatography—mass spectrometry. Fifteen different compounds eluting after hippuric acid have been identified, including two, cinnamoylglycine and acetyltributylcitrate, which have not been recognised previously. Relative retention times and abbreviated mass spectra of the identified compounds are presented.
AbstractList The profile of high boiling point organic acids in urine samples from both normal subjects and patients suspected of having some form of metabolic disorder has been determined by combined gas chromatography—mass spectrometry. Fifteen different compounds eluting after hippuric acid have been identified, including two, cinnamoylglycine and acetyltributylcitrate, which have not been recognised previously. Relative retention times and abbreviated mass spectra of the identified compounds are presented.
Author Jellum, Egil
Stokke, Oddvar
Brown, Garry K.
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Cites_doi 10.1016/0009-8981(71)90329-9
10.1093/clinchem/19.6.586
10.1016/S0009-9120(77)90290-9
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10.1021/ac60358a074
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10.1093/clinchem/17.8.789
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Snippet The profile of high boiling point organic acids in urine samples from both normal subjects and patients suspected of having some form of metabolic disorder has...
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StartPage 177
SubjectTerms Acids - urine
Chromatography, Gas
Cinnamates - urine
Citrates - urine
Glycine - analogs & derivatives
Glycine - urine
Hippurates - urine
Hot Temperature
Humans
Mass Spectrometry
Metabolism, Inborn Errors - urine
Title Chromatographic profile of high boiling point organic acids in human urine
URI https://dx.doi.org/10.1016/S0378-4347(00)81337-7
https://www.ncbi.nlm.nih.gov/pubmed/649712
Volume 145
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