Genetic interactions between the ESS1 prolyl-isomerase and the RSP5 ubiquitin ligase reveal opposing effects on RNA polymerase II function

• Published in: Current genetics Vol. 40; no. 4; pp. 234 - 242
• Main Authors: Wu, Xiaoyun, Chang, Alex, Sudol, Marius, Hanes, Steven
• Format: Journal Article
• Language: English
• Published: United States 01.12.2001
• Subjects: binding sites; Binding, Competitive; chemistry; Cyclin-Dependent Kinase 8; Cyclin-Dependent Kinases; Cyclin-Dependent Kinases - metabolism; DNA-directed RNA polymerase; Endosomal Sorting Complexes Required for Transport; ESS1 gene; Fungal Proteins; Fungal Proteins - genetics; Fungal Proteins - metabolism; gene interaction; genes; genetics; growth & development; isomerases; ligases; metabolism; Models, Genetic; mutants; Mutation; NIMA-Interacting Peptidylprolyl Isomerase; Peptides; Peptides - metabolism; Peptidylprolyl Isomerase; Peptidylprolyl Isomerase - genetics; Peptidylprolyl Isomerase - metabolism; Phosphoprotein Phosphatases; Phosphoprotein Phosphatases - metabolism; Protein Binding; Protein Kinases; Protein Structure, Tertiary; RNA Polymerase II; RNA Polymerase II - chemistry; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; RPB1 gene; RSP5 gene; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins; Temperature; transcription (genetics); Ubiquitin-Protein Ligase Complexes

Transcription of protein-coding genes by RNA polymerase II (pol II) is a highly coordinated process that requires the stepwise association of distinct protein complexes with the C-terminal domain (CTD) of Rpbl, the largest subunit of RNA pol II. Interaction of these complexes with the CTD might be s...