Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

• Published in: American journal of respiratory and critical care medicine Vol. 181; no. 9; pp. 928 - 934
• Main Authors: Lommatzsch, Marek, Cicko, Sanja, Müller, Tobias, Lucattelli, Monica, Bratke, Kai, Stoll, Paul, Grimm, Melanie, Dürk, Thorsten, Zissel, Gernot, Ferrari, Davide, Di Virgilio, Francesco, Sorichter, Stephan, Lungarella, Giuseppe, Virchow, J. Christian, Idzko, Marco
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.05.2010
• Subjects: Adenosine Triphosphate - analysis; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bronchoalveolar Lavage Fluid - chemistry; Chronic obstructive pulmonary disease, asthma; Cytokines - analysis; Extracellular Fluid - chemistry; Female; Humans; Intensive care medicine; Macrophages, Alveolar - chemistry; Male; Medical sciences; Middle Aged; Neutrophils - chemistry; Pneumology; Pulmonary Disease, Chronic Obstructive - metabolism; Receptors, Purinergic - analysis; Sarcoidosis - metabolism; Smoking - metabolism; Up-Regulation; Lung disease; purinergic receptors; Purine nucleoside; Adenosine; Intensive care; Respiratory disease; Tobacco smoking; smoking; Bronchus disease; Chronic obstructive pulmonary disease; ATP; Resuscitation; extracellular ATP

Extracellular ATP promotes inflammation, but its role in chronic obstructive pulmonary disease (COPD) is unknown. To analyze the expression of ATP and its functional consequences in never-smokers, asymptomatic smokers, and patients with COPD. ATP was quantified in bronchoalveolar lavage fluid (BALF)...