Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias

• Published in: Brain (London, England : 1878) Vol. 137; no. 9; pp. 2509 - 2521
• Main Authors: Foster, Vincent, Oakley, Arthur E., Slade, Janet Y., Hall, Roslyn, Polvikoski, Tuomo M., Burke, Matthew, Thomas, Alan J., Khundakar, Ahmad, Allan, Louise M., Kalaria, Raj N.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2014
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Aging - pathology; Aging - psychology; Alzheimer Disease - diagnosis; Alzheimer Disease - psychology; Biological and medical sciences; Brief Psychiatric Rating Scale - standards; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia, Vascular - diagnosis; Dementia, Vascular - physiopathology; Dementia, Vascular - psychology; Female; Fundamental and applied biological sciences. Psychology; Humans; Isolated neuron and nerve. Neuroglia; Male; Medical sciences; Neurology; Organic mental disorders. Neuropsychology; Prefrontal Cortex - blood supply; Prefrontal Cortex - pathology; Prospective Studies; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Pyramidal Cells - pathology; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; Stroke; Executive function; Nervous system diseases; Vascular dementia; Alzheimer disease; Ageing; Central nervous system; Cardiovascular disease; Prefrontal cortex; Encephalon; Cerebral disorder; Vascular disease; Central nervous system disease; Degenerative disease; Pyramidal neuron; Alzheimer's disease; post-stroke dementia; Cerebrovascular disease; ageing; Alzheimer’s disease; prefrontal cortex; vascular dementia; stroke; executive function

Dementia associated with cerebrovascular disease is common. It has been reported that ∼30% of elderly patients who survive stroke develop delayed dementia (post-stroke dementia), with most cases being diagnosed as vascular dementia. The pathological substrates associated with post-stroke or vascular...