Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise

• Published in: Archives of toxicology Vol. 99; no. 2; pp. 815 - 824
• Main Authors: Isenmann, Eduard, Lachenmeier, Dirk W., Flenker, Ulrich, Lesch, Alessio, Veit, Sebastian, Diel, Patrick
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2025; Springer Nature B.V
• Subjects: Administration, Oral; Adult; adverse effects; alanine transaminase; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Athletes; Biomedical and Life Sciences; Biomedicine; Cannabidiol; Cannabidiol - administration & dosage; Cannabidiol - adverse effects; Cannabidiol - toxicity; Cannabinoids; Creatinine; Creatinine - blood; Cross-Over Studies; Double-Blind Method; Environmental Health; Enzymatic activity; Enzyme activity; exercise; Exercise - physiology; Female; gamma-glutamyltransferase; gamma-Glutamyltransferase - blood; hepatotoxicity; Humans; Liver; Liver - drug effects; Liver - enzymology; Male; Occupational Medicine/Industrial Medicine; oils; Oils & fats; Organ Toxicity and Mechanisms; oxaloacetic acid; Pharmacology/Toxicology; Physiological effects; Placebos; Pyruvic acid; Side effects; Toxicity; Transaminase; Transaminases; Young Adult; γ-Glutamyltransferase; Liver function; Cannabidiol; Exercise; Toxicity; Kidney function

The side effects and safety of cannabidiol (CBD) products are currently discussed in different contexts. Of all adverse effects, hepatotoxic effects have been reported most frequently in previous studies. However, the threshold for liver toxicity of CBD in humans is uncertain due to the lack of adeq...