Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies — A SPECT with 5-HTTLPR genotyping study

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 61; pp. 24 - 29
• Main Authors: Lin, Shih-Hsien, Lee, I Hui, Chen, Kao Chin, Chen, Po See, Chiu, Nan Tsing, Yao, Wei Jen, Yang, Yen Kuang
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.08.2015
• Subjects: Adult; Cinanserin - analogs & derivatives; Cinanserin - pharmacokinetics; Depression; Depression - diagnostic imaging; Depression - genetics; Female; G × E interaction; Genotype; Humans; Life Change Events; Male; Mesencephalon - diagnostic imaging; Mesencephalon - pathology; Middle Aged; Polymorphism, Single Nucleotide - genetics; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin transporter; Sex Factors; Single-photon emission computed tomography; Statistics, Nonparametric; Stress, Psychological - diagnostic imaging; Stress, Psychological - genetics; Surveys and Questionnaires; Taiwan; Tomography, Emission-Computed, Single-Photon; Young Adult; TDQ; MRI; SRE; G×E interaction; GLM; Depression; MDD; ROI; RLCQ; SPECT; SUR; SERT; Serotonin transporter; G×E; FWHM; l-DOPA; Single-photon emission computed tomography; PCR; PET

It was found that serotonin transporter (SERT) gene (5-HTTLPR) polymorphism may moderate the association between perceiving stress and depressive tendency. Although SERT availability in the central nervous system could be associated with 5-HTTLPR polymorphism, whether SERT availability moderates the...